The demand for skilled program leadership continues to rise as companies nationwide build distributed engineering organizations. Senior technical program manager remote jobs are opening up across the USA, with 500+ positions currently available for professionals ready to guide complex, cross-functional initiatives from home. This growth reflects how businesses increasingly rely on strong technical oversight to keep large-scale projects on track.
Success in this position calls for deep experience coordinating large, cross-functional efforts, translating ambiguous business goals into clear execution plans, and communicating effectively with stakeholders at every level. Fluency in agile methodologies, risk management, and cloud infrastructure is essential, along with a proven ability to lead engineering and product teams toward shared outcomes. Companies looking to hire a senior technical program manager typically prioritize candidates who combine strategic thinking with hands-on delivery experience.
Remote work for this role typically involves close collaboration across time zones, asynchronous communication, and reliance on digital tools to keep distributed teams aligned. The USA market for remote programmatic leadership keeps expanding, with tech companies, startups, and enterprises embracing flexible, remote-first cultures. As more organizations decentralize their engineering operations, senior technical program manager positions continue to grow in both number and strategic importance.
If you're ready to take the next step in your career, now is a great time to explore senior technical program manager vacancies across the USA. Global Work AI connects experienced professionals with employers seeking exceptional delivery leadership for remote roles nationwide. Discover new possibilities and find the right fit for your next big move.
EverOn Data Center Services
The Senior Program Manager will take a lead role in delivering some of the most advanced data center portfolios in the country. This position is designed for someone who thrives on ownership, brings...
remote, United StatesFull TimeSenior (5+ years)Pyramid Consulting
Immediate need for a talented Senior Technical Program Manager – AI Research and Language Projects . This is a 06+ Months Contract opportunity with long-term potential and is located in US (Remote) ....
remote, United States$151k – $171k/yrFull TimeSenior (5+ years)
Bureau Veritas
A WORLD LEADER IN TESTING, INSPECTION & CERTIFICATION SERVICES Bureau Veritas offers dynamic, exciting employment opportunities with an attractive salary/benefit package and an opportunity to play a...
remote, United StatesFull TimeSenior (5+ years)
PERSUIT
About PERSUIT PERSUIT is a legal spend management platform that helps the world's largest organizations bring transparency, efficiency, and control to how they manage outside counsel. Following our...
remote, United States$143k – $150k/yrFull TimeSenior (5+ years)
Motive
Who we are: Motive empowers the people who run physical operations with tools to make their work safer, more productive, and more profitable. For the first time ever, safety, operations and finance...
remote, United States$127k – $175k/yrFull TimeSenior (5+ years)
Microsoft
Overview The next breakthrough in artificial intelligence (AI) needs more than powerful accelerators: it needs a network that makes them work as a supercomputer. On Azure Networking’s infrastructure...
remote, United States$120k – $261k/yrFull TimeSenior (5+ years)
Symetra
About the role The Senior Technical Program Manager is accountable for the planning and execution of medium-complexity technical programs that span technical teams and domains. As a Senior TPM, you...
remote, United States$129k – $215k/yrFull TimeSenior (5+ years)
Kenect
About us Kenect is a leading AI-powered texting and reputation management platform used by 10,000+ dealerships and service businesses across North America. We help companies streamline communication,...
remote, Pleasant Grove, Utah, United StatesFull TimeSenior (5+ years)Microsoft
Overview The Cloud & AI organization accelerates Microsoft’s mission and bold ambitions to ensure that our company and industry is securing digital technology platforms, devices, and clouds in our...
remote, United States$120k – $275k/yrFull TimeSenior (5+ years)Microsoft
Overview MCAPS-Core accelerates customer outcomes and business growth. By uniting product, engineering, marketing, sales, customer success, and partners around a common customer mission, we help...
remote, United States$102k – $235k/yrFull TimeSenior (5+ years)
Nebius
About Nebius: Nebius is leading a new era in cloud infrastructure for the global AI economy. We are building a full-stack AI cloud platform that supports developers and enterprises from data and...
remote, United States$115k – $275k/yrFull TimeSenior (5+ years)
Clutch
Position Title: Sr. Program Manager Manager’s Title: VP | Operations CLUTCH is a hybrid consultancy and agency focused on working with B2B companies that intend to grow and accelerate their...
remote, Minneapolis, Minnesota, United StatesFull TimeSenior (5+ years)
Thermo Fisher Scientific
Work Schedule First Shift (Days) Environmental Conditions Office Job Description Role purpose The Senior Program Manager will establish the operating model that brings together AI-related work across...
remote, California, United States$115k – $165k/yrFull TimeSenior (5+ years)
Axon
Join Axon and be a Force for Good. At Axon, we’re on a mission to Protect Life. We’re explorers, pursuing society’s most critical safety and justice issues with our ecosystem of devices and cloud...
remote, United StatesFull TimeSenior (5+ years)
G-P
About Us Our leading SaaS-based Global Employment Platform™ enables clients to expand into over 180 countries quickly and efficiently, without the complexities of establishing local entities. At G-P,...
remote, California, United States$83k – $124k/yrFull TimeSenior (5+ years)
Jobgether
This position is listed on behalf of a partner company, who manages all applications and next steps. Our partner is looking for a Senior Technical Program Manager based in United States. This...
remote, United StatesFull TimeSenior (5+ years)
KH Aerospace
Kraus Hamdani Aerospace (KHA) is an aerospace company specializing in long-endurance unmanned aerial platforms for a wide variety of industries. KHA supports a number of customers to carry out...
remote, United StatesFull TimeSenior (5+ years)
ImageTrend
Job Description About Us: ImageTrend, LLC. is dedicated to connecting life’s most important data in the healthcare and emergency response community. We deliver software solutions, data analytics and...
remote, United States$90k – $120k/yrFull TimeMiddle (2-4 years)
Muon Space
About the role Muon seeks a Senior Technical Program Manager - Propulsion Systems to lead the end-to-end planning of the development, manufacturing and test of our propulsion systems. This role may...
remote, Alabama, United States$206k – $232k/yrFull TimeSenior (5+ years)
Expleo
Overview Location: Remote, United States Work Model: Fully Remote Trissential is seeking an accomplished Senior Program Manager to join our client’s team. This is an opportunity to take ownership of...
remote, United States$156k – $166k/yrFull TimeSenior (5+ years)
Snowflake
At Snowflake, we are powering the era of the agentic enterprise. To usher in this new era, we seek AI-native thinkers across every function who are energized by the opportunity to reinvent how they...
remote, United StatesFull TimeSenior (5+ years)
Fluxon
Who we are We are Fluxon, a product development team founded by ex-Googlers and startup founders. We offer full-cycle software development from ideation and design to build and go-to-market. We...
remote, United States$107k – $137k/yrFull TimeSenior (5+ years)
Backblaze External Website
About Backblaze Backblaze is the object storage leader in the open cloud movement, fueling customer success with cloud storage built purposefully to unlock budgets, unburden administrators, and...
remote, United States$130k – $150k/yrFull TimeSenior (5+ years)Microsoft
Overview Are you eager to shape the future of cloud computing and solve engineering challenges at a scale few can imagine? Join the Microsoft Azure Storage Engineering team as a Senior Technical...
remote, United States$120k – $261k/yrFull TimeSenior (5+ years)
Everyday Electric
Who We Are Everyday Electric (formerly Renew Home) is on a mission to change how we power the world by making it easier for customers to save energy and money at home as part of the largest...
remote, United States$185k – $225k/yrFull TimeSenior (5+ years)
General Dynamics Information Technology
Job Description GDIT is looking for a Senior Technical Solutions Manager to own the delivery posture across our entire U.S. Courts portfolio — currently four active call orders under the Case...
remote, United States$187k – $224k/yrFull TimeSenior (5+ years)
OncoHealth
About OncoHealth OncoHealth is a leading digital health company dedicated to helping health plans, employers, providers, and patients navigate the physical, mental, and financial complexities of...
remote, United StatesFull TimeSenior (5+ years)
CyrusOne
CyrusOne is a leading global data center developer and operator, delivering secure, scalable, and reliable infrastructure solutions for the world’s largest enterprises and hyperscale customers. We...
remote, WA, United StatesFull TimeSenior (5+ years)
Ethos Life
About Ethos Ethos is a leading life insurance technology company on a mission to protect families by democratizing access to life insurance and empowering agents at scale. With its robust three-sided...
remote, United States$133k – $235k/yrFull TimeSenior (5+ years)
Airbnb
Airbnb was born in 2007 when two hosts welcomed three guests to their San Francisco home, and has since grown to over 5 million hosts who have welcomed over 2 billion guest arrivals in almost every...
remote, United States$232k – $282k/yrFull TimeSenior (5+ years)
Human Interest
Human Interest is on a mission to ensure that people in all lines of work have access to retirement benefits. More than half of all working Americans are not saving enough for their future. Too...
remote, United States$200k – $220k/yrFull TimeSenior (5+ years)
SentinelOne
Our Purpose At SentinelOne, we are driven by a clear purpose: to give the advantage to those who secure our future. As AI reshapes how organizations build, operate, and innovate, the responsibility...
remote, United States$132k – $182k/yrFull TimeSenior (5+ years)
Nscale
About Nscale Nscale is the GPU cloud engineered for AI. We provide cost-effective, high-performance infrastructure for AI start-ups and large enterprise customers. Nscale enables AI-focused companies...
remote, United States$180k – $210k/yrFull TimeSenior (5+ years)
Personified Tech
Who We Are We’re Personified: a managed IT + cybersecurity services provider for campaigns, non-profits, and mission-aligned organizations. Our mission is to lead technology and security programs for...
remote, United StatesFull TimeSenior (5+ years)
Avalara
What You'll Do As a Senior Technical Program Manager on the Customer Onboarding Operations and Technical Programs team reporting to the Sr. Manager of Business Operations & Strategic Programs, you...
remote, United StatesFull TimeSenior (5+ years)
Atlassian
Overview Working at Atlassian Atlassians can choose where they work – whether in an office, from home, or a combination of the two. That way, Atlassians have more control over supporting their...
remote, United States$196k – $308k/yrFull TimeSenior (5+ years)
GitLab
GitLab is the intelligent orchestration platform for DevSecOps. GitLab enables organizations to increase developer productivity, improve operational efficiency, reduce security and compliance risk,...
remote (anywhere)Full TimeSenior (5+ years)
Slate Auto
ABOUT SLATE At Slate, we’re building safe, reliable vehicles that people can afford, personalize and love—and doing it here in the USA as part of our commitment to reindustrialization. The spirit of...
remote, United StatesFull TimeSenior (5+ years)
Viasat, Inc.
About us One team. Global challenges. Infinite opportunities. At Viasat, we’re on a mission to deliver connections with the capacity to change the world. For more than 35 years, Viasat has helped...
remote, United States$148k – $275k/yrFull TimeSenior (5+ years)
Form Health
Form Health is a virtual obesity medicine clinic delivering physician-led, evidence-based care for obesity and related cardiometabolic conditions. Obesity affects more than 40% of U.S. adults, and as...
remote, United States$140k – $165k/yrFull TimeSenior (5+ years)10,000,000+ more jobs available!
