Companies nationwide are actively looking to hire a senior systems engineer to strengthen their infrastructure and cloud operations teams. With 500+ open positions available, this remote opportunity allows professionals across the USA to contribute to mission-critical infrastructure without geographic constraints. The demand for senior systems engineer remote jobs continues to grow as organizations prioritize scalable, resilient technology environments.
Successful candidates typically bring deep expertise in systems administration, network architecture, and cloud platforms such as AWS, Azure, or Google Cloud. Strong scripting abilities in Python or Bash, combined with experience in automation tools like Ansible or Terraform, are highly valued. Employers also seek professionals skilled in troubleshooting complex infrastructure issues, ensuring uptime, and collaborating with cross-functional teams to deliver secure, efficient solutions.
Remote work for this role has become the standard across the USA, with many companies offering flexible schedules and distributed team structures. The hiring outlook remains strong, as businesses in finance, healthcare, and technology sectors continue expanding their remote infrastructure teams. Senior systems engineer vacancies are especially competitive in states with thriving tech hubs, though remote arrangements now open doors nationwide.
If you're ready to advance your career, explore current senior systems engineer positions available through Global Work AI. Take the next step toward a rewarding, flexible role that matches your technical expertise and career goals.
Amerihealth Caritas
For roles that are 100% remote or hybrid, you must have access to a reliable high-speed internet connection to support daily job responsibilities. A minimum bandwidth of 50 Mbps download and 5 Mbps...
remote, United StatesFull TimeSenior (5+ years)
Airbnb
Airbnb was born in 2007 when two hosts welcomed three guests to their San Francisco home, and has since grown to over 5 million hosts who have welcomed over 2 billion guest arrivals in almost every...
remote, United States$164k – $193k/yrFull TimeSenior (5+ years)
PSC Consulting
Senior Power Systems Engineer – EMT Who We Are The energy transition is vital to our future, and here at PSC, we are compelled to make a difference. We are specialist consultants to the energy...
remote, United States$150k – $220k/yrFull TimeSenior (5+ years)Critical Facility Group
About Critical Facility Group Critical Facility Group (CFG) is an MEP consulting and owner's project management firm specializing in data centers and mission-critical facilities. Our engineers and...
remote, United StatesFull TimeSenior (5+ years)
Govcio LLC
GovCIO is currently hiring for a Senior Systems Engineer to support the Cloud Data Pipeline (CDP) and engineering services across the U.S. Coast Guard (USCG). This position supports the...
remote, United States$120k – $145k/yrFull TimeSenior (5+ years)
Microsoft
Overview GitHub is seeking a Senior Software Engineer to join the Git Systems Engineering team, which runs the largest code-hosting platform in the world, part of our Platform and Infrastructure...
remote, United States$120k – $261k/yrFull TimeSenior (5+ years)
VetsEZ
VetsEZ is seeking a Team Lead / Senior Systems Engineer to support enterprise healthcare IT operations for the Department of Veterans Affairs (VA). This role leads the systems engineering and...
remote, United StatesFull TimeLead / Manager
Flexport
About Flexport: At Flexport, we believe global trade can move the human race forward. That’s why it’s our mission to make global commerce so easy there will be more of it. We’re shaping the future of...
remote, United States$106k – $172k/yrFull TimeSenior (5+ years)
Lynx
Who we are: Lynx delivers modular, open standards–based software that transforms how high-assurance, mission-critical edge systems are built, deployed, and maintained. Our secure edge computing...
remote, United StatesFull TimeSenior (5+ years)
Bidgely, Inc
About Bidgely We are an AI-powered, cloud-based SaaS solution provider that enables electric, gas and water utilities worldwide to personalize customer experiences, optimize grid and customer...
remote, United StatesFull TimeSenior (5+ years)Compex Legal Services
ABOUT THE ROLE We’re looking for an experienced Senior Systems & Security Engineer to help strengthen and secure our IT environment while keeping our systems reliable, scalable, and running smoothly....
remote, United StatesFull TimeSenior (5+ years)
Innovas
The Senior Business Systems Engineer designs, builds, integrates, and modernizes the business applications and data flows that support organizational operations. Reporting to the Senior Director of...
remote, NC, United StatesFull TimeSenior (5+ years)
Jobgether
This position is listed on behalf of a partner company, which manages all applications and next steps. Our partner is looking for a Senior Model Based Systems Engineer based in the United States. We...
remote, United States$89k – $148k/yrFull TimeSenior (5+ years)
SAIC
SAIC is seeking a highly motivated and experienced Mission Systems Engineer to support NSWC Crane and the Multi-Service Advanced Capabilities Hypersonic Test Bed (Mach-TB) Program. In this role, you...
remote, Crane, IN, United StatesFull TimeSenior (5+ years)
Sparkfund
About Sparkfund Sparkfund is the utility services company unlocking capacity on the grid. Through its Distributed Capacity Procurement (DCP) model, Sparkfund enables utilities, energy majors, and...
remote, United States$145k – $180k/yrFull TimeSenior (5+ years)
The Home Depot
With a career at The Home Depot, you can be yourself and also be part of something bigger. Position Purpose: The Sr. Systems Engineer is responsible for independently developing, maintaining, and...
remote, United States$80k – $160k/yrFull TimeSenior (5+ years)Jobgether
This position is listed on behalf of a partner company, who manages all applications and next steps. Our partner is looking for a Senior Systems Engineer – Infrastructure & Security based in the...
remote, United StatesFull TimeSenior (5+ years)Jobgether
This position is listed on behalf of a partner company, who manages all applications and next steps. Our partner is looking for a Senior IT Systems Engineer based in the United States. As a Senior IT...
remote, United States$145k/yrFull TimeSenior (5+ years)
Hewlett Packard Enterprise
Senior Presales Systems Engineer - FL This role has been designated as ‘Remote/Teleworker’, which means you will primarily work from home. Who We Are: Hewlett Packard Enterprise is the global...
remote, FL, United States$152k – $355k/yrFull TimeSenior (5+ years)Hewlett Packard Enterprise
Senior Presale Systems Engineer - CA This role has been designated as ‘Remote/Teleworker’, which means you will primarily work from home. Who We Are: Hewlett Packard Enterprise is the global...
remote, CA, United States$172k – $355k/yrFull TimeSenior (5+ years)
Quest Defense Systems & Solutions, Inc.
We’re seeking engineers who thrive on solving hard problems and turning bold ideas into real-world solutions. If you’re driven to design, develop, and test technology that truly makes an impact,...
remote, Wichita, KS, United States$130k – $180k/yrFull TimeSenior (5+ years)
Innovatus Technology Consulting
Job Title: Senior Systems Engineer – Infrastructure & Security Company: Innovatus Technology Consulting Location: Fully Remote Overview Innovatus Technology Consulting is looking for a Senior Systems...
remote, United StatesFull TimeSenior (5+ years)Mitsubishi Electric Power Products
Position: Principal System Studies Engineer – Power Systems Mitsubishi Electric Power Products, Inc. (MEPPI) is seeking a highly skilled Principal System Studies Engineer to lead advanced power...
remote, United States$143k – $164k/yrFull TimeSenior (5+ years)
Cribl
Join the company that’s building the telemetry infrastructure for the AI era. At Cribl, we partner with IT and Security teams at many of the world’s biggest enterprises, including half of the Fortune...
remote, United States$99k – $156k/yrFull TimeSenior (5+ years)
Care Access
About Care Access Care Access is working to make the future of health better for all. With hundreds of research locations, mobile clinics, and clinicians across the globe, we bring world-class...
remote, United States$120k – $170k/yrFull TimeSenior (5+ years)
Rocket Companies
This posting will be open until November 30, 2026. Applications received after this date may not be considered. The Senior Systems Engineer designs, builds, and integrates server and platform...
remote, MI, United States$84k – $207k/yrFull TimeSenior (5+ years)
Tech Data Costa Rica
About the Role We are seeking a hands-on Infrastructure Engineer to focus primarily on capacity and demand planning across data centers and public cloud. You will combine practical infrastructure...
remote, United StatesFull TimeSenior (5+ years)
Sabre Systems LLC
Responsibilities Sabre Systems is currently recruiting a Senior Systems Engineer to support the Ford Class Launch and Recovery Fleet Support Team (FST) Division, specifically, the Electromagnetic...
remote, United States$135k – $160k/yrFull TimeSenior (5+ years)
Uptalent.io
Location: Remote, U.S. (Dallas-Fort Worth area preferred) Employment Type: Full-Time Travel: Approximately 20% domestic travel required About the Opportunity Join a fast-growing clean-energy...
remote, United StatesFull TimeSenior (5+ years)
Ōura
Our mission at Oura is to empower every person to own their inner potential. Our award-winning products help our global community gain a deeper knowledge of their readiness, activity, and sleep...
remote, United States$147k – $203k/yrFull TimeSenior (5+ years)
Huntington National Bank
Senior Mainframe Systems/Platform Engineer Position Overview-(Remote-Onsite) The Senior Mainframe Platform Engineer is responsible for the engineering, health, security, resiliency, connectivity, and...
remote, United StatesFull TimeSenior (5+ years)
Leidos
Few IT jobs come with a mission like this one! Leidos is looking for a Senior Systems Engineer to support the United States Antarctic Program (USAP) under the National Science Foundation’s Antarctic...
remote, United States$92k – $167k/yrFull TimeSenior (5+ years)
Business Wire
Business Wire, a Berkshire Hathaway company, is the global market leader in press release distribution and regulatory disclosure. We are on a mission to redefine how organizations connect with their...
remote, United States$130k – $135k/yrFull TimeSenior (5+ years)Hewlett Packard Enterprise
Senior Presales, Systems Engineer This role has been designated as ‘Remote/Teleworker’, which means you will primarily work from home. Who We Are: Hewlett Packard Enterprise is the global...
remote, Sunnyvale, CA, United States$203k – $420k/yrFull TimeSenior (5+ years)
Qumulo
Qumulo's cloud data platform manages exabytes of the world's most demanding data, unifying files, objects, and every workload across edge, core, and cloud. About the role: This is a senior technical...
remote, FL, United States$235k – $265k/yrFull TimeSenior (5+ years)
Mob Entertainment
Mob Entertainment is a startup multimedia studio that is best known for our hit indie horror game "Poppy Playtime". This franchise is one of the hottest new properties in gaming, and our team is...
remote, CA, United States$101k – $177k/yrFull TimeSenior (5+ years)
Pharmavite
HELP US BRING THE GIFT OF HEALTH TO LIFE. Working at Pharmavite is an experience like no other. With a focus on complete nutrition for all, each endeavor is urgent and every day counts. You'll have...
remote, West Hills, CA, United States$117k – $216k/yrFull TimeSenior (5+ years)The Home Depot
With a career at The Home Depot, you can be yourself and also be part of something bigger. Position Purpose: The Systems Engineer Sr. Principal is responsible for overseeing the development,...
remote, United States$170k – $280k/yrFull TimeSenior (5+ years)
Enlyte
Company Overview At Enlyte, we combine innovative technology, clinical expertise, and human compassion to help people recover after workplace injuries or auto accidents. We support their journey back...
remote, United States$81k – $110k/yrFull TimeSenior (5+ years)
BDR Solutions LLC
BDR Solutions, LLC, (BDR) supports the U.S. Federal Government in successfully achieving its mission and goals. Our service and solution delivery starts with understanding each client's end-state,...
remote, United States$120k – $150k/yrFull TimeSenior (5+ years)10,000,000+ more jobs available!
