Demand for senior software engineer remote jobs keeps growing across the United States as companies modernize their technology stacks and seek proven engineering talent. With 500+ open positions available, this role suits experienced professionals ready to contribute to meaningful projects without relocating. The fully remote setup lets engineers throughout the USA collaborate with distributed teams while maintaining a healthy work-life balance.
Successful candidates typically bring strong expertise in backend and frontend development, cloud infrastructure, and scalable system design. Proficiency in languages such as Python, Java, or JavaScript, along with experience in CI/CD pipelines and microservices architecture, is highly valued. Employers looking to hire a senior software engineer also prioritize problem-solving skills, mentorship ability, and a track record of delivering clean, maintainable code within agile teams.
Remote work for this role has become standard practice rather than the exception, as employers across the USA embrace distributed teams to access broader talent pools. Many organizations now offer asynchronous collaboration tools and flexible schedules, making remote senior software engineer vacancies increasingly appealing. The nationwide hiring outlook stays strong, fueled by ongoing digital transformation and continued investment in software development across industries.
If you're ready to advance your career, explore the latest senior software engineer positions available through Global Work AI. Our platform connects talented engineers with forward-thinking companies seeking skilled professionals ready to make an impact. Discover opportunities that match your expertise and take the next step today.
Providi
Design and deliver complex features end to end using Java and PHP, while contributing to front-end work as needed. Mentor junior engineers through code reviews and design feedback, and identify and resolve bottlenecks in code and tooling.
remote (anywhere)Full TimeSenior (5+ years)
The Home Depot
Develop, test, deploy, and maintain software applications. Collaborate with team members in agile processes and create valuable user stories. Mentor junior engineers and lead technical discussions. Implement production monitoring, performance tuning, and security measures.
remote, United States$80k – $180k/yrFull TimeSenior (5+ years)
Airbnb
Design and build distributed systems for user data management. Lead multi-engineer projects from problem definition to rollout. Improve reliability and scalability of backend services handling account data. Collaborate with engineering teams to execute changes to shared infrastructure.
remote, United States$196k – $227k/yrFull TimeSenior (5+ years)Peerless Technologies
Design, develop, test, and maintain complex software systems using Rust or similar languages. Optimize software for Linux environments, manage distributed containerized applications, and implement messaging systems and APIs.
remote, United StatesFull TimeSenior (5+ years)
GE HealthCare
Develop scalable, cloud-based software solutions and own software components. Collaborate with cross-functional teams to deliver high-quality software, applying test-driven development and engineering best practices. Design and maintain user-facing applications, APIs, and distributed services.
remote, United States$110k – $164k/yrFull TimeSenior (5+ years)
Empower Pharmacy
Design and implement scalable backend systems for pharmacy operations, manufacturing, and logistics. Ensure compliance with architectural standards and participate in design reviews. Optimize system performance and reliability through fault-tolerant design and performance analysis.
remote, United StatesFull TimeSenior (5+ years)
Cambium
Lead the design, development, and deployment of major features across Cambium's platform, including data infrastructure and client-facing interfaces. Write clean, maintainable code with a focus on security and reliability.
remote (anywhere)Full TimeSenior (5+ years)
Cotiviti
Design and implement event-driven microservices and Angular/React front ends. Own technical design decisions throughout the application life cycle and resolve production issues in distributed systems. Configure CI/CD pipelines, lead code reviews, and mentor junior engineers.
remote, United States$111k – $145k/yrFull TimeSenior (5+ years)
Impinj
Build and ship web applications end-to-end, focusing on frontend development. Collaborate with designers on user interfaces and build APIs, data models, and backend services.
remote, United States$159k – $238k/yrFull TimeSenior (5+ years)
IRIS
Design and deliver scalable systems, including APIs and data-processing solutions. Own features from design to production support, build applications using C#, .NET Core, and ASP.NET Core, and influence architecture decisions.
remote, United StatesFull TimeSenior (5+ years)
Ambry Genetics
Architect and deliver Java-based services for platform modernization. Design and implement Spring Boot microservices, drive legacy system refactoring, and cloud migration. Establish engineering standards for CI/CD, testing, and observability.
remote, United States$130k – $150k/yrFull TimeSenior (5+ years)
Tebra
Lead the development of a micro front-end architecture for the Practice Management platform. Design and implement reusable front-end tools and components, ensuring optimal performance across devices.
remote, United States$171k – $182k/yrFull TimeSenior (5+ years)
JR Recruiting
Design and build cloud-native, event-driven planning and optimization services. Contribute to the technical roadmap and architectural direction of the platform. Develop proofs of concept using emerging technologies, and mentor other engineers through design and code reviews.
remote, MO, United StatesFull TimeSenior (5+ years)
DRFIRST COM INC
Build and improve Gadget, the pharmacy agent, and contribute to Rcopia's EPCS and PDMP capabilities. Design, develop, test, deploy, and maintain secure, scalable Java integration solutions.
remote, United States$130k – $150k/yrFull TimeSenior (5+ years)
GoodLeap
Design and implement front-end frameworks and shared component libraries. Utilize AI-driven software processes to build and expand front-end and full stack services. Collaborate with product teams to deliver high-quality solutions and lead initiatives.
remote, CA, United States$132k – $197k/yrFull TimeSenior (5+ years)
Pinterest Job Advertisements
Lead technical projects with cross-functional teams to identify and manage risks on the Pinterest platform. Design and implement scalable services for automated risk identification and reporting. Drive architectural improvements and mentor junior engineers on best practices and workflows.
remote, United States$203k – $255k/yrFull TimeSenior (5+ years)
MESO SCALE DIAGNOSTICS, LLC.
Design, develop, and test software for external-facing products, including client, web, or server-side applications. Lead development sprints, conduct unit testing, and troubleshoot issues.
remote, Gaithersburg, MD, United States$101k – $155k/yrFull TimeSenior (5+ years)ＲＥＶＯＬＵＴＩＯＮ
Design, develop, and maintain high-quality code for BCycle applications, ensuring integration across services. Provide technical leadership and guidance to junior team members, contribute to architectural design, and participate in scrum ceremonies.
remote, CA, United StatesFull TimeSenior (5+ years)
CertifyOS
Own end-to-end delivery of features from design to deployment and support. Build scalable and maintainable systems to meet evolving product needs. Improve reliability and code quality through strong engineering practices and participate in on-call rotation for operational excellence.
remote, United StatesFull TimeSenior (5+ years)
ASG
Lead software development projects across ASG's portfolio companies, focusing on full stack development. Train and mentor engineering teams on AI-native coding practices, and design workshops to enhance productivity.
remote (anywhere)$180k – $200k/yrFull TimeSenior (5+ years)
Evry Health
Architect and build backend services, APIs, and cloud infrastructure for Evry Health's platform. Lead design of microservices and event-driven architecture, ensuring compliance with healthcare data standards.
remote, United StatesFull TimeSenior (5+ years)
UnitedHealth Group
Design, develop, and deploy AI-powered solutions for complex business challenges. Maintain high-performing backend and frontend services using C#, .NET Core, Angular, and SQL databases. Architect and optimize automated CI/CD pipelines for reliable software delivery.
remote, United States$92k – $164k/yrFull TimeSenior (5+ years)
Microsoft
Design, build, test, and operate production-grade software and services. Partner with customers to clarify requirements and translate business needs into technical designs. Drive engineering best practices including code reviews and automated testing.
remote, United States$120k – $261k/yrFull TimeSenior (5+ years)
BILL
Develop and maintain scalable billing and monetization systems. Implement REST API and GraphQL solutions for customer-facing pricing experiences. Ensure data integrity and accuracy in financial systems. Collaborate with internal teams to enable quick billing for new products.
remote, United States$130k – $183k/yrFull TimeSenior (5+ years)
Episode Six
Code, test, analyze, and review software for accuracy, functionality, performance, and security. Drive the Software Development Life Cycle, define sprint goals, and lead product launches.
remote, TX, United States$167k – $190k/yrFull TimeSenior (5+ years)
WEXWEXUS
Contribute to the architecture, design, and implementation of the Beyond Fuel and Expense Management platform. Build full-stack capabilities, translate product requirements into technical designs, and establish standards for automated testing and secure development.
remote, CA, United States$122k – $146k/yrFull TimeSenior (5+ years)
Synapse Health
Own backend services and technical solutions from design through production support. Debug complex technical issues, improve system reliability, and build automation to reduce developer toil.
remote, United States$160k – $185k/yrFull TimeSenior (5+ years)Brim
Lead the architecture, development, and optimization of full-stack services using PHP and Python. Design and implement RESTful APIs and microservices, optimize MySQL performance, and drive engineering standards for quality and CI/CD workflows.
remote, United States$104k – $137k/yrFull TimeSenior (5+ years)
Prompt.io Inc.
Design, build, test, and maintain scalable applications, services, and APIs. Own complex technical projects from design through implementation and maintenance. Collaborate with Product to translate needs into technical solutions and contribute to the architecture of the SaaS platform.
remote, United States$125k – $175k/yrFull TimeSenior (5+ years)
Alto Pharmacy
Develop and optimize backend services for prescription processing, ensuring accuracy and efficiency. Lead projects to enhance automation in prescription intake and pharmacist workflows.
remote, United States$160k – $200k/yrFull TimeSenior (5+ years)
Block
Lead large-scale changes across codebases, including framework upgrades and dependency updates. Design agentic loops for AI-driven engineering tasks, identify and resolve developer workflow friction, and enhance build tooling and CI performance.
remote, United States$185k – $327k/yrFull TimeSenior (5+ years)
Baylor Genetics
Lead the design and development of software solutions aligned with business objectives. Provide technical guidance and mentorship to junior engineers. Conduct code reviews to ensure adherence to coding standards and best practices. Contribute to the architectural design of software systems.
remote, United StatesFull TimeSenior (5+ years)
Canals
Perform backend engineering focused on scalability, performance, and reliability. Own complex projects from planning to deployment, collaborating with product and customer teams.
remote, United StatesFull TimeSenior (5+ years)
3Pillar
Develop high-quality client code that is efficient, testable, and scalable. Manage project tracking and documentation, gather requirements, and ensure adherence to quality standards. Collaborate with engineers and designers to address user pain points and lead projects from design to launch.
remote, United StatesFull TimeSenior (5+ years)
DEFINITI LLC
Design, develop, and integrate business solutions and software using Microsoft .NET, Foundry, and Power Platform. Build and support distributed n-tier applications, maintain software quality, and follow coding standards.
remote, United StatesFull TimeSenior (5+ years)
C.H. Robinson
Design and build C.H. Robinson's planning and optimization platform. Develop cloud-native services that support supply chain planning capabilities. Create APIs and event-driven services for seamless integration. Mentor engineers and contribute to technical roadmaps and architectural direction.
remote, IL, United States$132k – $223k/yrFull TimeSenior (5+ years)
Upstart
Design, build, and operate backend systems for secure login, account management, authentication, and authorization. Own projects from technical design through implementation and testing.
remote, United States$167k – $242k/yrFull TimeSenior (5+ years)
BarkleyOKRP
Design, develop, and maintain high-performance Java applications. Architect scalable RESTful APIs and optimize complex SQL queries for relational databases. Manage version control using Git and GitHub, ensuring clean code history and collaborative code reviews.
remote (anywhere)Full TimeSenior (5+ years)
Enverus
Develop and enhance SBS's Distribution Tools platform using C#, .NET, and cloud APIs. Collaborate with senior developers to translate requirements into software, write unit and integration tests, and support CI/CD automation.
remote, United StatesFull TimeSenior (5+ years)
SOLVENTUM
Lead software development initiatives to implement innovative solutions in the healthcare sector. Collaborate with R&D teams to deliver impactful solutions, ensuring customer needs are met. Develop web applications and component libraries, and interface with services through REST APIs.
remote, PA, United States$124k – $171k/yrFull TimeSenior (5+ years)10,000,000+ more jobs available!
