Companies across the United States are actively seeking a seasoned technology leader to guide their engineering vision, and 500+ senior CTO remote jobs are currently open for qualified candidates. This role combines strategic oversight with hands-on innovation, making it one of the most sought-after senior CTO positions in today's competitive tech market. As organizations embrace distributed teams, remote work has become the standard for executive tech roles nationwide.
The strongest candidates for this position bring deep expertise in cloud architecture, scalable systems design, and agile leadership, paired with a track record of building high-performing engineering teams. Strong communication skills, strategic vision, and the ability to align technology roadmaps with business goals are essential. Employers looking to hire a senior CTO also value experience in cybersecurity, DevOps practices, and cross-functional collaboration across departments.
Remote work for a senior CTO in the USA typically involves flexible scheduling, virtual leadership of distributed engineering teams, and reliance on modern collaboration tools to maintain productivity. Demand for this level of remote executive talent continues to rise as companies prioritize digital transformation and decentralized operations. Regional hiring outlook remains strong, with tech hubs across the country actively recruiting for this role.
If you are ready to take the next step in your executive technology career, explore current senior CTO vacancies available now. Global Work AI connects top-tier tech leaders with companies eager to hire a senior CTO who can drive innovation and growth. Join a network built for ambitious tech executives today.
Reimagine Work
Lead the technical architecture and infrastructure strategy for AI infrastructure deployment. Oversee product development, OEM partnerships, and engineering recruitment. Manage technical execution globally and define the modular and distributed AI infrastructure for the next decade.
remote (anywhere)$170k – $221k/yrFull TimeVP / C-level
Precision for Medicine
Plan, direct, and coordinate clinical study projects to meet quality, scope, cost, and time objectives. Manage study budgets, oversee project profitability, and ensure compliance with billing and forecasting.
remote, United States$147k – $221k/yrFull TimeSenior (5+ years)
Precision Medicine Group
Plan, direct, and coordinate clinical study projects to meet quality, scope, cost, and time objectives. Manage study budgets, oversee functional services, and ensure compliance with billing and forecasting. Develop project plans, manage risks, and ensure quality management for assigned projects.
remote, United States$147k – $221k/yrFull TimeSenior (5+ years)
UNITED STATES POLO ASSOCIATION INC
Lead the development and execution of enterprise technology strategy, overseeing IT infrastructure and data governance. Ensure cybersecurity and data integrity while implementing AI initiatives to enhance operations.
remote, United StatesFull TimeVP / C-level
Hitachi Solutions
Lead enterprise-scale business transformation solutions using Microsoft technologies. Define solution strategies, oversee architecture governance, and manage critical program strategies including data migration and security.
remote, United States$170k – $210k/yrFull TimeSenior (5+ years)
Medtronic
Lead the promotion and sale of Medtronic’s coronary portfolio, providing technical and clinical leadership during coronary interventions. Deliver advanced clinical education to healthcare professionals and build relationships with key opinion leaders.
remote, CT, United States$85k/yrFull TimeSenior (5+ years)
Partnership for Large Election Jurisdictions
Lead financial management and internal operations, including budgeting, forecasting, and compliance. Establish operating practices, monitor progress, and ensure accountability across teams.
remote, United States$141k – $168k/yrFull TimeDirector
Atomicwork
Lead technical strategy for complex enterprise pursuits, acting as a trusted advisor to CIOs and CTOs. Build prototypes, reference architectures, and migration playbooks.
remote, United StatesFull TimeVP / C-levelNew Leaders
Develop and implement the technology vision and strategy for New Leaders. Oversee technology infrastructure, ensuring security and compliance while managing data governance. Lead system integrations and data migration initiatives, optimizing data flow and platform scalability.
remote, United States$172k – $225k/yrFull TimeVP / C-level
ACA Group
Lead mock regulatory examinations and compliance program reviews, including document preparation and report drafting. Provide regulatory consulting services, manage client relationships, and oversee junior staff.
remote, Chattanooga, TN, United States$180k – $200k/yrFull TimeVP / C-level
Evolution Research Group
Manage and execute clinical study operations, ensuring compliance with regulations and guidelines. Lead project teams through the full project cycle, including budgeting, timeline adherence, and communication with stakeholders.
remote, United StatesFull TimeSenior (5+ years)
City of Tacoma
Lead the development and execution of technology strategies aligned with TPU's goals. Oversee technology portfolio governance, project planning, and implementation. Champion the deployment of emerging technologies to improve utility operations and customer experience.
remote, United States$203k – $285k/yrFull TimeVP / C-level
Professional Case Management
Define and execute the technology product strategy for the Research and Home Care Division. Collaborate with cross-functional teams to develop scalable technology solutions, enhance existing offerings, and drive new functionality.
remote, United States$135k – $225k/yrFull TimeDirector
Jobgether
Lead cybersecurity engagements focused on Continuous Threat Exposure Management (CTEM) and vulnerability management. Conduct assessments, document findings, and develop remediation strategies.
remote, United States$170k – $180k/yrFull TimeSenior (5+ years)Jobgether
Lead the development and maintenance of ATO documentation, including SSPs, POA&Ms, and SARs. Conduct security assessments, risk assessments, and continuous monitoring to ensure compliance with federal cybersecurity requirements.
remote, United StatesFull TimeMiddle (2-4 years)Slipstream IT
Partner with stakeholders to gather and prioritize requirements for Vault Clinical. Translate business needs into user stories and functional specifications; conduct fit-gap analyses and recommend changes. Facilitate workshops, maintain a requirements traceability matrix, and execute test scripts.
remote, United States$120k – $130k/yrFull TimeSenior (5+ years)
Airbnb
Lead the BizTech Enablement and Innovation team to drive AI adoption across non-technical functions. Define multi-year strategies for AI impact, assess gaps, and simplify tools for business teams. Set organizational OKRs, hold teams accountable, and communicate trade-offs.
remote, United States$204k – $255k/yrFull TimeSenior (5+ years)
AHEAD
Lead client assessments of Continuous Threat Exposure Management (CTEM) and vulnerability management programs.
remote, United States$170k – $180k/yrFull TimeSenior (5+ years)
USA TODAY Co.
Define and execute product vision and strategy, translating it into actionable roadmaps and measurable outcomes. Drive product-led growth and innovation across digital products, overseeing the full product lifecycle from discovery to optimization.
remote, United States$450k – $480k/yrFull TimeVP / C-level
Microsoft
Lead end-to-end security value propositions, including Zero Trust and Cloud Adoption. Define secure strategies and architectures for Microsoft Security adoption, aligning with Azure and Microsoft 365 services.
remote, United States$106k – $204k/yrFull TimeSenior (5+ years)
Analogue Insight
Define and own the technology vision for electrical and photonic interconnects. Translate strategy into a multi-year IP roadmap, prioritizing investments and managing technical risks.
remote, United StatesFull TimeVP / C-level
Thermo Fisher Scientific
Serve as the primary contact between the sponsor and vendor, ensuring project delivery on time, cost, and quality. Lead cross-functional project teams, manage financial stewardship, and drive risk identification and issue resolution.
remote, MA, United States$130k – $171k/yrFull TimeSenior (5+ years)
APS
Develop and execute APS's enterprise digital strategy, ensuring alignment with organizational priorities. Lead digital transformation initiatives to enhance employee and customer experiences.
remote, United States$290k – $395k/yrFull TimeVP / C-level
FEDSYNC
Lead the corporate PMO overseeing federal contracts, establish program management standards, and maintain portfolio-level financial performance. Conduct monthly program management reviews, mentor Program and Project Managers, and partner with Business Development on proposals.
remote, United StatesFull TimeSenior (5+ years)Microsoft
Provide strategic technology leadership for the Civilian and Tribal Nations business, shaping technology and business strategies for key accounts. Serve as a trusted advisor to senior Federal leaders, guiding technology strategies and enterprise transformations.
remote, United States$158k – $267k/yrFull TimeVP / C-level
Anomali
Provide pre-sales technical support for SIEM and Cyber Threat Intel solutions, driving new business opportunities and achieving sales quotas. Lead technical aspects of pre-sales engagements, deliver product demonstrations, and maintain communication with prospects and customers.
remote, United StatesFull TimeSenior (5+ years)Forvis Mazars, LLP
Support the implementation and optimization of ERP solutions for construction. Analyze client needs, configure systems, and assist in project planning, documentation, and task tracking.
remote, United States$86k – $173k/yrFull TimeSenior (5+ years)
Total Life, Inc.
Write, review, and ship code across the stack while leading AI-first product development. Co-own the strategic roadmap, integrating marketing technology and healthcare infrastructure. Build features that drive patient engagement and retention, ensuring HIPAA compliance and security.
remote, United StatesFull TimeVP / C-level
QuilrAI
Serve as a senior technical advisor to enterprise customers on AI security strategy. Lead technical strategy sessions, architecture workshops, and discussions on securing AI applications. Guide the design of enterprise AI security architectures and provide oversight for proof-of-concept engagements.
remote, United StatesFull TimeVP / C-level
Insurity
Develop and implement Insurity’s enterprise information security strategy, policies, and control framework. Lead HIPAA compliance and risk management initiatives, ensuring appropriate safeguards for protected health information.
remote, United States$216k – $325k/yrFull TimeVP / C-levelMaximus
Lead and track the development and implementation of complex strategic initiatives across multiple teams. Manage project expectations, evaluate needs, and communicate with stakeholders. Oversee project management functions including scheduling, monitoring progress, and staff assignments.
remote, United States$140k – $160k/yrFull TimeSenior (5+ years)
Stand Together
Set strategic direction for enterprise cybersecurity, developing and executing a security strategy aligned with business objectives. Lead enterprise security architecture, protecting critical systems and cloud environments.
remote, Arlington, VA, United States$240k – $275k/yrFull TimeVP / C-level
Workato
Serve as a trusted advisor to C-suite executives, leading strategic engagements and architecture reviews. Present AI execution strategies to Boards and executive committees, influencing complex transformation decisions. Partner with Sales on strategic enterprise pursuits, accelerating deal closures.
remote, United StatesFull TimeVP / C-level
Banyan Software
Lead product direction and technology strategy for a vertical SaaS business. Oversee engineering and product organizations, ensuring reliable platform architecture. Drive AI integration and product-led growth initiatives, while maintaining customer trust and delivery momentum.
remote, United StatesFull TimeVP / C-level
FFB Bank
Lead the development and execution of the Bank's technology strategy, including infrastructure, cybersecurity, and digital transformation initiatives. Oversee technology operations, ensuring systems meet performance and security standards.
remote, Fresno, CA, United StatesFull TimeVP / C-level
Black Canyon Consulting
Lead cross-functional teams to define and deliver product features aligned with business objectives. Collaborate with Engineering, UX, and QA to refine product capabilities and manage backlog prioritization.
remote, United States$140k – $160k/yrFull TimeSenior (5+ years).jpg&w=128&q=75)
King'S Insurance Staffing
Lead application development and enterprise technology implementations, focusing on legacy system migrations and modernization initiatives. Collaborate with business leaders to prioritize projects and improve efficiency.
remote, United States$190k – $210k/yrFull TimeVP / C-level
Foundation
Oversee delivery for a $3M+ portfolio, managing multiple teams or a flagship program. Set delivery standards, manage effort estimates, and ensure timely execution of client plans.
remote, United States$120k – $145k/yrFull TimeSenior (5+ years)
Athos Commerce
Lead product and technology strategy, overseeing Product Management, Engineering, System Architecture, and Platform Operations. Drive product innovation, improve customer experiences, and ensure technology security and scalability.
remote, United StatesFull TimeVP / C-level
FHI 360
Oversee data analytics and visualization for emergency response activities, ensuring quality data collection and reporting. Develop dashboards and analytics products to support decision-making, and provide technical direction to project staff.
remote, United States$86k – $116k/yrFull TimeSenior (5+ years)10,000,000+ more jobs available!
