The demand for python jobs in the USA continues to climb as companies embrace remote-first engineering teams to build scalable software solutions. We currently have 63 open positions for talented developers eager to contribute to innovative projects from anywhere in the country. This is an excellent opportunity for professionals seeking flexibility without compromising on meaningful, high-impact work.
Successful candidates typically bring strong command of core python frameworks, along with experience in API development, database management, and version control systems like Git. Familiarity with cloud platforms such as AWS or Azure is highly valued, as is a solid understanding of software design principles and testing methodologies. Strong problem-solving skills and the ability to collaborate effectively across distributed teams are essential, since companies increasingly hire a python specialist who can adapt quickly to evolving project needs.
Remote work has become the standard for many python vacancies across the USA, with companies offering flexible schedules and asynchronous collaboration tools to support distributed teams. Regional hiring outlook remains strong, particularly in tech hubs where startups and enterprises alike compete for skilled talent. This shift has opened doors for developers nationwide, allowing them to access python positions that once required relocation or daily commutes.
If you are ready to take the next step in your career, explore the latest opportunities available through Global Work AI. Our platform connects skilled developers with companies actively seeking remote talent, making it easier than ever to find a role that matches your expertise and ambitions. Discover how Global Work AI can help you land your next great opportunity today.
Turing
Design and refine rubrics and evaluation criteria for preference data. Review and label data with a focus on quality, identifying subtle issues. Build and maintain pipelines and infrastructure for data workflows.
remote, Austin, TX, United StatesFull TimeJunior (<2 years)Turing
Create datasets for training and benchmarking large language models, curate code examples, and provide solutions primarily in Python. Evaluate and refine AI-generated code for efficiency and scalability, and collaborate with cross-functional teams to enhance AI-driven coding solutions.
remote, United States$403k/yrPart TimeMiddle (2-4 years)
RTI International
Develop and maintain Python or SQL code to analyze complex healthcare data from relational databases. Collaborate with research teams to transform data into analytic insights for reports and publications. Participate in code reviews and documentation to ensure quality standards.
remote, United States$91k – $112k/yrFull TimeMiddle (2-4 years)RTI International
Analyze and synthesize complex healthcare data from multiple sources. Develop and maintain SAS, SQL, or Python code for data analysis, ensuring efficiency and quality. Construct analytic datasets and collaborate with project teams to translate business requirements into programming logic.
remote, United States$132k – $163k/yrFull TimeLead / Manager
Gramian Consulting Group
Develop reproducible Python-based analyses, models, and data-processing workflows. Analyze biological datasets using computational methods, review scientific solutions for accuracy, and identify errors in reasoning or code.
remote, United StatesPart TimeJunior (<2 years)
Highmark Health
Lead a team of application developers in building and maintaining scalable software applications. Drive technical execution across the software development lifecycle, from idea generation to deployment. Collaborate with stakeholders to model data sources and define operational frameworks.
remote, PA, United States$94k – $151k/yrFull TimeLead / ManagerHighmark Health
Collect, analyze, and report on key performance indicators using Python and Tableau. Develop dashboards, scorecards, and executive presentations to support operational excellence. Collaborate with cross-functional teams to identify data needs and facilitate process improvements.
remote, PA, United States$79k – $127k/yrFull TimeSenior (5+ years)
Xperteez Technology
Apply scientific expertise to create and solve research problems in biology and related fields. Use Python for data analysis, develop reproducible solutions, validate computational results, and review scientific solutions and code for accuracy and clarity.
remote (anywhere)Part TimeJunior (<2 years)
Intetics
Design and implement a scalable mobile automation framework. Develop and maintain automated tests for Android and iOS applications using Appium. Create and maintain test scenarios in Xray, integrate automated tests with a device farm, and analyze test execution results.
remote, GA, United StatesFull TimeSenior (5+ years)
Latitude AI
Support vehicle simulations by improving the sim/resim cloud framework and applications. Analyze performance bottlenecks, create benchmarking, and implement solutions for efficiency. Ensure the framework is intuitive and well-documented for user self-service.
remote, United States$150k – $225k/yrFull TimeMiddle (2-4 years)
EPAM Systems
Architect and implement backend services using Python 3.11, FastAPI, and SQLAlchemy async. Design retrieval quality trade-offs and build production-grade agent runtime capabilities. Improve answer grounding and create observability loops using OpenTelemetry and Prometheus.
remote, United StatesFull TimeJunior (<2 years)
ICON plc
Lead the development and implementation of data science solutions for clinical trials. Oversee data programming activities, maintain data pipelines, and generate visualized output analysis to support clinical research.
remote, Blue Bell, PA, United StatesFull TimeSenior (5+ years)
3Pillar Global
Develop strategies for acquiring research data from laboratory instruments. Engineer custom file parsers for diverse output formats and implement robust data models and scalable data pipelines.
remote, United StatesFull TimeSenior (5+ years)
Pavago
Take ownership of the existing Python codebase, troubleshoot live issues, and maintain production systems. Improve data pipelines and automations, maintain and extend APIs and integrations, and document workflows.
remote, United StatesFull TimeMiddle (2-4 years)
Acquired Data Solutions
Design and develop automated test software using LabVIEW and Python. Integrate instruments and hardware with test software, and design automated test stations for production.
remote, DC, United StatesFull TimeMiddle (2-4 years)
Bright Vision Technologies
Design, develop, test, and maintain application components using Python and relevant frameworks. Integrate applications with databases and external services, participate in code reviews, and ensure release readiness.
remote, United States$115k – $165k/yrFull TimeMiddle (2-4 years)
Mitratech
Develop and optimize CI/CD pipelines incorporating AI agents for code generation and testing. Conduct code reviews for both human and AI-generated code, ensuring quality and security. Design structured instructions for AI agents and contribute to technical documentation.
remote, United StatesFull TimeSenior (5+ years)Bright Vision Technologies
Design, develop, test, and maintain application components using Python and relevant frameworks. Integrate applications with databases and external services, participate in code reviews, and ensure release readiness.
remote, United States$115k – $165k/yrFull TimeMiddle (2-4 years)
InvestEngine
Build and maintain backend services using Python 3.11 with Django/DRF. Automate back office processes, design and improve REST APIs, and resolve production issues. Contribute to architecture discussions and improve development processes while maintaining high code quality and testing standards.
remote (anywhere)Full TimeMiddle (2-4 years)EPAM Systems
Design and implement responsive web interfaces and maintain server-side services and APIs. Optimize backend performance and collaborate with cross-functional teams to integrate components. Write clean code, conduct testing and debugging, and review code to ensure quality.
remote, United StatesFull TimeLead / Manager
Torus
Develop firmware features for energy storage products, ensuring seamless integration with hardware and software teams. Drive quality through design reviews and automated testing, while debugging and optimizing embedded applications.
remote, UT, United States$135k – $180k/yrFull TimeJunior (<2 years)
G2i Inc.
Evaluate AI-generated coding interactions, assessing their usefulness and correctness. Provide clear feedback on the quality of explanations and reasoning. Distinguish between levels of response quality and help define standards for interactions with AI coding tools.
remote (anywhere)$202k – $403k/yrPart TimeSenior (5+ years)
Clario
Design, develop, and maintain Python applications and automation frameworks for clinical data processing. Lead modernization of SAS-based workflows with scalable Python solutions. Build solutions for data ingestion, transformation, validation, and reporting.
remote, United StatesFull TimeSenior (5+ years)InvestEngine
Design, develop, and maintain backend services using Python 3.11 and Django/DRF. Lead projects from requirements to production, clarify requirements, and propose technical designs. Build RESTful APIs for web and mobile apps, conduct code reviews, and contribute to architecture discussions.
remote (anywhere)Full TimeSenior (5+ years)
Torrero
Make architectural decisions for the product backend, implement design, develop backend features, and write tests. Monitor production operations and performance, optimizing as necessary. Ensure completion of assigned tasks and integration of new payment methods and data providers.
remote (anywhere)Full TimeMiddle (2-4 years)
Infosys
Develop and deploy Python applications to address IT operational needs, automate processes, and manage data. Implement cloud applications and utilize Databricks for data engineering and analytics.
remote, United States$66k – $102k/yrFull TimeMiddle (2-4 years)
Brandeis University
Facilitate course logistics and ensure timely rollout of content, maintain communication through announcements, and oversee instructional activities on digital platforms. Engage students through live sessions and forums, providing feedback and grading based on established rubrics.
remote, United States$7k/yrPart TimeJunior (<2 years)Amalga Group SA de CV
Design, build, and maintain enterprise web applications using * on the frontend and Python on the backend. Modernize complex enterprise workflows by transitioning legacy tools into digital solutions.
remote, United StatesFull TimeSenior (5+ years)IIIIIIUS
Design, develop, test, and maintain data pipelines and transformation workflows using SQL, Python, and Databricks. Optimize PostgreSQL database objects and queries, and build integrations for DataConnect reporting with AWS QuickSight.
remote, United States$81k – $168k/yrFull TimeMiddle (2-4 years)
Adastra Corporation
Provide technical leadership and hands-on development for SAS-to-Python migration. Analyze business and technical requirements to design scalable solutions. Lead the migration of SAS programs and datasets to Python, develop and maintain Python applications, and establish coding standards.
remote, United StatesFull TimeLead / ManagerAdastra Corporation
Analyze business and technical requirements to design scalable solutions. Migrate SAS programs and datasets to Python environments, develop and maintain Python applications, and build Unix-based automation pipelines.
remote, United StatesFull TimeMiddle (2-4 years)
EXL
Drive the design, build, and implementation of pricing tools to enhance market deployment. Lead complex projects, coordinate with team members and stakeholders, and establish technical standards.
remote, United StatesFull TimeSenior (5+ years)Xperteez Technology
Apply scientific expertise to create and solve complex research problems in biology and related fields. Use Python for data analysis, develop reproducible solutions, validate computational results, and review scientific solutions and code for accuracy and clarity.
remote (anywhere)Part TimeJunior (<2 years)
Coherent Solutions, Inc.
Take ownership of backend services from design to deployment. Develop and maintain scalable distributed backend services using Python and Django. Optimize systems for performance and resilience, implement testing strategies, and collaborate with cross-functional teams to deliver features.
remote, United StatesFull TimeLead / Manager
JBS Dev
Design, build, test, and maintain Python applications, backend services, RESTful APIs, and microservices. Own production software through its full lifecycle, integrating third-party services and implementing secure authentication.
remote, United States$125k – $145k/yrFull TimeSenior (5+ years)
EDB
Develop and maintain responsive web applications using Next.js and Node.js. Write clean, maintainable Python code for backend services and data processing. Build and monitor automated workflows and data pipelines using Airflow and dbt.
remote, United States$110k – $125k/yrFull TimeSenior (5+ years)
Weekday AI
Design and refine rubrics and evaluation frameworks for preference data. Review and label data, identifying quality issues and opportunities for improvement. Build and maintain pipelines and infrastructure for data workflows.
remote, United States$202k – $302k/yrPart TimeSenior (5+ years)
Supabase
Develop and maintain the Python SDK for Supabase, ensuring it supports database, auth, storage, and realtime functions with both sync and async APIs. Triage issues, review contributions, and maintain CI and release automation.
remote (anywhere)Full TimeJunior (<2 years)G2i Inc.
Evaluate AI-generated coding interactions, assessing their usefulness and correctness. Provide clear feedback on the quality of explanations and reasoning, and distinguish between different levels of response quality. Help define standards for effective interactions with AI coding tools.
remote (anywhere)$202k – $403k/yrPart TimeSenior (5+ years)
Checkmk GmbH
Develop and enhance the monitoring solution, collaborating with UX, QA, Security, and Product Management teams. Utilize technologies such as Python, Jenkins, and VueJS to ensure platform updates and seamless customer experiences.
remote, United StatesFull TimeJunior (<2 years)10,000,000+ more jobs available!
