Companies across the United States are actively seeking talented professionals to fill 315 senior artificial intelligence remote jobs, reflecting a surge in demand for advanced machine learning expertise. As organizations embrace digital transformation, remote work has become the standard for top-tier AI talent, allowing skilled engineers to contribute from anywhere in the country. This growing wave of senior artificial intelligence vacancies signals a thriving tech ecosystem ready to welcome new innovators.
Successful candidates typically bring deep expertise in machine learning frameworks such as TensorFlow and PyTorch, along with strong programming skills in Python. Employers looking to hire a senior artificial intelligence specialist often prioritize candidates who can lead cross-functional teams, design scalable architectures, and translate complex data into actionable insights. Familiarity with cloud platforms, natural language processing, and MLOps practices further strengthens a candidate's profile in this competitive field.
Remote senior artificial intelligence positions in the USA typically offer flexible schedules, collaborative virtual environments, and access to cutting-edge projects across industries like healthcare, finance, and technology. As more companies adopt distributed teams, the hiring outlook for remote AI professionals continues to strengthen, with employers competing to attract experienced specialists who can drive innovation without geographic constraints.
If you're ready to advance your career and make an impact in artificial intelligence, explore the latest opportunities available through Global Work AI. Our platform connects passionate professionals with forward-thinking companies eager to hire a senior artificial intelligence expert, making it easier than ever to find your next remote role.
RSS, LLC.
Set up the enterprise AI and automation platform, including model routing and workflow automation. Discover automation opportunities by embedding with teams and mapping workflows. Build and deliver AI tools and automations from pilot to production, ensuring safe integration with internal data.
remote, CA, United States$180k – $200k/yrFull TimeSenior (5+ years)
Infosys
Contribute to requirements elicitation and document business requirements. Facilitate software design discussions and document decisions. Participate in coding, conduct code reviews, and maintain code repositories. Implement test strategies, analyze results, and coordinate bug fixes.
remote, United States$66k – $102k/yrFull TimeSenior (5+ years)
GR8_TECH
Design, build, and operate production-grade AI agent infrastructure and services on AWS. Develop agent orchestration, stateful workflows, and implement reliable execution with checkpointing and retries.
remote (anywhere)Full TimeSenior (5+ years)
Space Dinosaurs
Lead product strategy and engineering execution for AI capabilities. Design, prototype, code, and ship AI systems while integrating various data sources. Establish evaluation frameworks for AI performance and collaborate with engineering teams to connect recommendations with implementation.
remote (anywhere)Full TimeDirector
Defense Unicorns
Design, build, and integrate AI agents and multi-agent workflows using modern LLM and agentic technologies. Develop agent capabilities that interact with enterprise applications, APIs, and data sources.
remote, United States$149k – $201k/yrFull TimeSenior (5+ years)
KBR
Design and develop AI courses for federal audiences, focusing on AI foundations, governance, ethics, and change management. Train and fine-tune neural-network models, evaluate AI outputs, and lead responsible AI adoption.
remote, United States$164k – $225k/yrFull TimeSenior (5+ years)
Horizon3
Identify and drive research problems at the intersection of AI and cybersecurity. Develop research directions, technical hypotheses, and experimental plans. Design and lead experiments, build prototypes, and evaluate results in collaboration with technical teams.
remote, United States$174k – $249k/yrFull TimeSenior (5+ years)
Versaterm
Lead the design and architecture of scalable software solutions, ensuring security and performance. Take ownership of projects from design to deployment, mentoring associate engineers and guiding them in AI tools.
remote, United StatesFull TimeSenior (5+ years)
First Citizens Bank
Advise on risk activities in alignment with corporate strategy, manage AI risks and controls, and execute risk policies. Collaborate with cross-functional teams to assess external factors and support the implementation of risk management frameworks.
remote, NC, United StatesFull TimeMiddle (2-4 years)
ClimateWorks Foundation
Lead the AI and automation agenda for ClimateWorks' philanthropic ecosystem, establishing standards for AI evaluation and deployment. Design and deploy AI-assisted workflows, improving data processing and machine learning for grant classification.
remote, United States$110k – $130k/yrFull TimeSenior (5+ years)
Pathward, N.A.
Research, design, and develop AI and machine learning models to address business challenges. Identify opportunities for AI technology, optimize existing models, and prepare data for training.
remote, AZ, United States$86k – $145k/yrFull TimeSenior (5+ years)
TRM Labs
Develop AI-powered agents and automations to streamline workflows for Product, Product Marketing, and Design teams. Collaborate with cross-functional teams throughout the product lifecycle, from discovery to launch.
remote, United StatesFull TimeSenior (5+ years)
EvolutionIQ
Design and build LLM-powered agents and workflows, including orchestration, tool use, retrieval, and structured extraction. Develop evaluations with data labelers and subject matter experts, ensuring agents are production-grade with proper guardrails and observability.
remote, Chicago, IL, United States$180k – $225k/yrFull TimeSenior (5+ years)
Cleveland Clinic
Research, develop, administer, and evaluate programs/projects for the Division. Oversee AI implementations, promote AI literacy, and collaborate with leaders on enterprise initiatives and budget management.
remote, OH, United StatesFull TimeSenior (5+ years)
Vanta
Build shared SDKs, APIs, and infrastructure for AI features. Integrate durable execution infrastructure for long-running workflows, including checkpointing and retries. Develop evaluation and debugging tools to improve production failures and support accurate AI behavior.
remote, United StatesFull TimeSenior (5+ years)
PointClickCare
Design and evolve the architecture of the AI Platform, ensuring scalability across the product portfolio. Guide the AI Engineering team through architectural decisions and provide technical mentorship.
remote, United States$183k – $229k/yrFull TimeSenior (5+ years)PointClickCare
Design and evolve the architecture of the AI Platform, ensuring scalability across the product portfolio. Guide the AI Engineering team through architectural decisions and provide technical mentorship.
remote, UT, United States$119k – $148k/yrFull TimeSenior (5+ years)
CCC Intelligent Solutions
Build and deploy statistical, machine learning, and hybrid LLM models on real claims data. Design evaluations and gold datasets, and continuously run them as products evolve. Measure impact through experiment design and ROI analysis, clearly communicating results to stakeholders.
remote, Chicago, IL, United States$180k – $225k/yrFull TimeSenior (5+ years)CCC Intelligent Solutions
Design and build LLM-powered agents and workflows, including orchestration, tool use, retrieval, and structured extraction. Collaborate with data labelers and subject matter experts to build evaluations and ensure production-grade agents with guardrails and observability.
remote, Chicago, IL, United States$180k – $225k/yrFull TimeSenior (5+ years)
GEICO
Lead the AI roadmap and delivery of secure, scalable AI solutions. Develop AI engineers and analysts, establishing delivery and quality standards. Guide AI solutions from discovery to deployment, partnering with data engineering and analytics teams to ensure trusted data and controls.
remote, United States$147k – $230k/yrFull TimeSenior (5+ years)
Left Field Labs
Design, build, and ship AI-powered features for the illumend platform, including data extraction and validation from insurance documents. Develop LLM pipelines and integrations across Python/FastAPI and React/TypeScript.
remote, CA, United States$155k – $175k/yrFull TimeSenior (5+ years)
Rearc
Design, build, and deploy production-grade AI-driven systems. Develop AI agents and orchestration workflows, implement observability and monitoring, and integrate AI systems into enterprise platforms.
remote, United StatesFull TimeSenior (5+ years)
Redhorse Corporation
Lead AI/ML initiatives for Condition-Based Maintenance Plus (CBM+), ensuring alignment with mission outcomes. Architect scalable data pipelines and oversee data workflows. Design and optimize machine learning models for predictive maintenance.
remote, United States$180k – $200k/yrFull TimeSenior (5+ years)
Humana
Analyze complex data sets to provide insights for decision-makers. Develop data visualizations to drive strategic direction and influence departmental strategy. Make decisions on technical approaches for project components and work independently on moderately complex issues.
remote, United States$89k – $121k/yrFull TimeSenior (5+ years)
Microsoft
Lead research on adversarial AI agents and swarm-like behavior. Build environments to observe agent coordination and develop methods to detect and interrupt offensive agent swarms. Stress-test methods across various conditions to identify evasion paths.
remote, United States$120k – $261k/yrFull TimeSenior (5+ years)
TriVista Business Group, Inc
Support the development of AI offerings and business development efforts. Advise clients on AI strategy and lead client conversations to connect AI opportunities with business objectives. Design and deliver AI-enabled solutions, ensuring alignment with client needs.
remote, United States$120k – $180k/yrFull TimeSenior (5+ years)1 Arc Power
Develop end-to-end software products including interactive interfaces, APIs, and backend services. Create tools for the entire plant lifecycle, from design to operations. Integrate automation and AI into plant design and operations. Analyze plant data to create actionable dashboards and insights.
remote, Mountain View, CA, United States$185k – $245k/yrFull TimeSenior (5+ years)1 Arc Power
Develop machine learning models to predict plant performance by integrating physics and ML. Build data pipelines for operations, maintenance, and field data. Package and deploy models in collaboration with Plant Infrastructure, ensuring they run effectively on-site.
remote, CA, United States$237k – $258k/yrFull TimeSenior (5+ years)
Kinetic
Build and operate Kinetic's agent orchestration layer, manage agents with CI/CD, and develop tools for secure access to data. Create evaluation harnesses and rollout gates for testing changes, and mentor engineers on agent design and code. Evaluate AI usage and make decisions on system components.
remote, United StatesFull TimeSenior (5+ years)Shoes For Crews North America
Design and maintain business intelligence solutions, write and optimize SQL queries, and develop AI-assisted reports. Create dashboards using Power BI and Tableau, ensuring data quality and governance.
remote, United States$150k – $160k/yrFull TimeSenior (5+ years)
Flexera
Design, build, test, deploy, and improve software using AI coding tools. Implement product features, APIs, and integrations while contributing to the software development lifecycle.
remote, United StatesFull TimeSenior (5+ years)Orbis
Architect and ship agents across the portfolio, including knowledge agents and goal-driven agents. Own the orchestration layer and design retrieval processes end to end. Build provenance paths for conclusions and establish evaluation infrastructure for agent quality.
remote, United StatesFull TimeSenior (5+ years)OneStream
Oversee the entire lifecycle of AI and software subsystems, including defining requirements, designing systems, and project planning. Lead the design and development of scalable applications, troubleshoot issues across the stack, and conduct code reviews.
remote, Birmingham, MI, United States$131k – $170k/yrFull TimeSenior (5+ years)
Wonderlic
Lead the development of the Jobs Engine, ensuring its architecture and integrity while expanding its capabilities. Collaborate with product managers and engineers to translate scientific requirements into AI systems.
remote, United States$130k – $150k/yrFull TimeSenior (5+ years)
Muttdata
Design and implement Machine Learning and AI solutions to enhance customer experience. Build recommendation and personalization models, develop customer segmentation and churn prediction models, and perform Exploratory Data Analysis.
remote (anywhere)Full TimeSenior (5+ years)
DeVry University
Develop and provide students with an approved syllabus, organize and update course materials, and utilize online technologies for course delivery. Set clear expectations for assignments and exams, ensure exam content aligns with course objectives, and provide timely feedback.
remote, AZ, United States$44k – $47k/yrPart TimeMiddle (2-4 years)
Abbott
Lead the development of AI and ML solutions for complex healthcare problems, collaborating with stakeholders to formalize requirements. Provide technical leadership in designing and deploying AI solutions, while also contributing hands-on to deliverables.
remote, United States$99k – $199k/yrFull TimeSenior (5+ years)
Relay (Uneven Labs, Inc.)
Own and improve Relay's internal AI agent, prioritizing tasks by impact and risk. Build knowledge systems for structured and unstructured information, ensuring accuracy and safety. Integrate agents with internal systems through APIs, focusing on permissions and failure recovery.
remote, United StatesFull TimeSenior (5+ years)
Emory University
Lead the AI Concierge function, assisting stakeholders in identifying and implementing AI use cases. Manage intake and consultation for AI requests, evaluate service needs, and provide implementation guidance.
remote, GA, United StatesFull TimeLead / Manager
Arc XP
Lead the technical direction of AI systems, including the Arc Intelligence API and personalization products. Own the design of the AI platform, manage multi-tenancy, and ensure system reliability.
remote, United States$145k – $241k/yrFull TimeSenior (5+ years)10,000,000+ more jobs available!
