Bioinformatics engineer, oligonucleotide drug discovery

As molecular data generation and frontier model intelligence grows, new approaches to data analysis are needed across the biotech industry. Latch is building intelligent, high performance agents for biological data analysis, empowering over 5,000 scientists across 150+ R&D labs to handle data from instrument-to-insights. We're seeking a BioEngineer for Oligonucleotide Discovery to join our therapeutics bench, working at the frontier of what artificial intelligence can achieve in biology.

About the Role

You will contribute to our technical approach to teaching agents how to understand and handle complex drug discovery and development data, working across end-to-end workflows from instrument outputs and experimental readouts to real scientific decisions. You will work as part of a team of software engineers, biologists, and drug hunters building datasets to teach these agents to reason better across:

• Genetic target and MoA selection
• ASO/siRNA drug design
• Screening and functional characterization
• Pharmacology

Requirements

• 3+ years hands-on experience with oligonucleotide (ASO/siRNA), RNA therapeutics, or related
• Experience in drug target validation or mechanism-of-action studies using functional or population genomics
• Familiarity with drug discovery and development workflows — sequence design, knockdown screening, or preclinical PK/PD
• Proficiency in AI agent use

Compensation & Logistics

• OTE 120k - 180k, performance based, based on individual's expertise
• Free meals (lunch and dinner)
• Waterfront office in China Basin, San Francisco
• Full-time, in-person (can be remote)