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  2. South Carolina
  3. Nurse Practitioner

Onsite Nurse Practitioner jobs in South Carolina, USA

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      Sarah Jenkins

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      Alex Chen

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      David G. (Hiring Manager)

    • 4:15 PM - 5:15 PM

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      Sophie L.

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      Marta W.

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      James Miller

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      Chris V.

  • Thu
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Nurse Practitioner Jobs in South Carolina — On-Site Opportunities Await

South Carolina's healthcare system continues to expand, creating strong demand for skilled nurse practitioners across hospitals and clinics. This on-site role offers 500+ open positions for professionals ready to deliver patient-centered care in a dynamic environment. Employers across the state are actively looking to hire a nurse practitioner who can provide both clinical expertise and compassionate service.

Successful candidates bring strong clinical assessment skills, excellent communication, and the ability to manage diverse patient caseloads independently. Familiarity with electronic health records, evidence-based treatment protocols, and collaborative care models is highly valued. Employers increasingly favor nurse practitioner positions that require adaptability, critical thinking, and a commitment to continuing education in evolving medical practices.

On-site nurse practitioner jobs in South Carolina typically involve close collaboration with physicians, specialists, and support staff within hospital or outpatient settings. The state's growing population and expanding rural health initiatives have fueled consistent demand for experienced providers willing to work directly within local communities. This hands-on environment fosters strong patient relationships and professional growth that remote positions often cannot replicate.

If you're ready to advance your career and make a meaningful impact in patient care, explore current nurse practitioner vacancies available through Global Work AI. Our platform connects dedicated professionals with top healthcare employers seeking passionate talent across South Carolina. Take the next step today and discover opportunities that match your skills and ambitions.

Frequently Asked
Questions

Everything you need to know about
finding your next role
  • What is the average nurse practitioner salary in South Carolina?

    Pay for a nurse practitioner in South Carolina varies by specialty, employer, and years of experience, but many openings land in the low-to-mid $100,000 range. Statewide figures commonly track below major coastal markets, yet hospital systems, primary care groups, and specialty clinics in larger metro areas may offer stronger packages. Compensation often includes shift differentials, productivity incentives, and benefits that affect total value. Review current South Carolina postings and compare base pay with bonus structures, since local demand can shift quickly.
  • What qualifications and state licensure are required for a nurse practitioner job?

    Most employers expect an active RN license, a graduate degree from an accredited MSN or DNP program, national certification in a population focus, and eligibility for South Carolina APRN practice authority. In this state, nurse practitioners also need to meet Board of Nursing requirements for prescriptive authority and controlled-substance registration when the role involves medications. Some healthcare settings prefer recent clinical experience in family practice, acute care, or a related area. It helps to verify both education and licensure details before applying, since facility rules can differ.
  • What are the main responsibilities of an on-site nurse practitioner?

    Day-to-day work usually centers on in-person assessment, diagnosis, treatment planning, follow-up care, and coordination with physicians, nurses, and support staff. In a South Carolina clinic or hospital, an on-site nurse practitioner may order and interpret tests, prescribe therapies, document visits in the EHR, and educate patients about prevention and chronic disease management. The exact scope depends on the employer, specialty, and local protocols. Many roles also involve triage and care coordination, so it is useful to compare job descriptions across different care environments.
  • What clinical skills are most important for a nurse practitioner role in a healthcare setting?

    Strong assessment skills matter most, especially the ability to gather histories, perform focused exams, and recognize when symptoms need urgent escalation. Safe prescribing, diagnostic reasoning, patient education, and clear charting are also essential in an on-site nurse practitioner role. In South Carolina healthcare settings, employers often look for confidence with EHR systems, teamwork across disciplines, and steady communication with patients from varied backgrounds. Time management and adaptability help during busy clinic days, so it can be helpful to review openings by specialty and setting.
  • What types of patients and conditions does a nurse practitioner typically manage?

    These professionals often care for people across the lifespan, depending on the practice area, from children and adults to older patients. Common concerns include hypertension, diabetes, asthma, infections, minor injuries, preventive visits, women’s health needs, and medication follow-up. In South Carolina, a nurse practitioner may also support patients with chronic conditions that require ongoing monitoring, especially in primary care, urgent care, or specialty practices. Scope varies by employer, so checking whether a role focuses on family medicine, acute care, or another track is a smart next step.
  • How does the hiring process usually work for nurse practitioner jobs in South Carolina?

    The process typically starts with an application and resume review, followed by interviews that may include a recruiter, hiring manager, and clinical leader. Many South Carolina employers also verify education, RN licensure, national certification, references, and background checks before extending an offer. For an on-site nurse practitioner role, some organizations add a shadow shift or case-based discussion to assess fit with the team. Timelines differ by system and specialty, so it helps to track requirements carefully and compare several openings before moving forward.
  • What career growth opportunities are available for nurse practitioners?

    Career paths can expand into specialty practice, leadership, education, quality improvement, or service-line management, depending on interest and experience. In South Carolina, a nurse practitioner may move from entry-level clinical work into roles with greater autonomy, advanced procedures, or population-specific expertise such as cardiology, oncology, or pediatrics. Some professionals pursue doctoral study, precepting, or administrative responsibilities as they build a longer-term career plan. Reviewing local job trends and comparing related roles can reveal which direction offers the best fit.

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500+ jobs found

  • A

    Apply for the Lead Aesthetic Nurse Practitioner / Physician Assistant job

    Today

    Lead aesthetic nurse practitioner / physician assistant job

    Lead Aesthetic Nurse Practitioner / Physician Assistant Job SkinGlow MD | Five Forks, Simpsonville, SC Four-Day Work week | $55–$70/Hour + Performance Bonus SkinGlow MD, a medical spa founded by...

    onsite, Simpsonville, SC, United States
    $111k – $141k/yrFull TimeLead / Manager
  • Lexington Medical Center

    Lexington Medical Center

    3 days ago

    Nurse practitioner

    Job Summary Assesses the physical and psychosocial status of patients by means of interview, health history, physical examination and diagnostic tests. Interprets the data, develops and implements a...

    onsite, Lexington, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health Urgent Care

    Prisma Health Urgent Care

    3 days ago

    Nurse practitioner or physician assistant | up to $7,500 sign on bonus

    Up to $7,500 Sign-On Bonus! Limited-time opportunity available to the eligible hires. Bonus eligibility and amount are subject to applicable terms and conditions. Prisma Health Urgent Care seeks...

    onsite, Seneca, SC, United States
    Full TimeJunior (<2 years)
  • Veterans Health Administration

    Veterans Health Administration

    4 days ago

    Nurse practitioner - psychiatric mental health

    Summary This position is eligible for the Education Debt Reduction Program (EDRP), a student loan payment reimbursement program. You must meet specific eligibility requirements per VHA policy and...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • AnMed

    AnMed

    5 days ago

    Nurse practitioner

    Providing psychotherapy and medical evaluation and management to a range of clients experiencing behavioral, mental and substance abuse disorders under the supervision of consulting psychiatrist(s)....

    onsite, Anderson, SC, United States
    Part TimeJunior (<2 years)
  • Your Health Organization

    Your Health Organization

    5 days ago

    Nurse practitioner - clinic provider

    We are seeking qualified Nurse Practitioner to service patients in the Chapin area. As a Provider, you play a critical role in delivering exceptional patient care in a clinic setting. You are an...

    onsite, Chapin, SC, United States
    $100k/yrFull TimeJunior (<2 years)
  • Otis College of Art and Design

    Otis College of Art and Design

    5 days ago

    Lead nurse practitioner

    Lead Nurse Practitioner We are searching for an experienced Lead Nurse Practitioner at our Goldsmith Campus - Westchester campus. Primary Duties and Responsibilities: PRIMARY PURPOSE: The Lead Nurse...

    onsite, Westchester, SC, United States
    $109k – $135k/yrFull TimeLead / Manager
  • ANDERSON AREA CANCER CENTER

    ANDERSON AREA CANCER CENTER

    6 days ago

    Nurse practitioner

    Cancer patients and cancer caregivers choose the Anderson Area Cancer Center as a provider because of our personal medical guidance. We have a unique ability to foster a renewed hope for those who...

    onsite, Anderson, SC, United States
    Full TimeJunior (<2 years)
  • Little River Medical Center

    Little River Medical Center

    6 days ago

    Family nurse practitioner

    Family Nurse Practitioner Flexible Full-Time or Part-Time Schedules Locations: Little River or Carolina Forest JOB SUMMARY: Under limited supervision by the Chief Medical Officer, the Family Nurse...

    onsite, Carolina Forest, NC, United States
    Full TimeMiddle (2-4 years)
  • Prisma Health

    Prisma Health

    6 days ago

    Nurse practitioner - pediatrics - acute care

    Nurse Practitioner - Pediatrics - Acute Care Inspire health. Serve with compassion. Be the difference. Job Summary Working directly with Intensivists to provide care to a specific patient population...

    onsite, Greenville, SC, United States
    Full TimeMiddle (2-4 years)
  • Prisma Health

    Prisma Health

    6 days ago

    Nurse practitioner - pediatrics acute care

    Job Summary Working directly with Intensivists to provide care to a specific patient population within the guidelines of written protocols. Will be performing critical care procedures such as, but...

    onsite, Greenville, SC, United States
    Full TimeMiddle (2-4 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    6 days ago

    Nurse practitioner or physician assistant - hematology oncology

    Job Description Summary The successful applicant will be an Advanced Practice Provider interested in working full-time in the care of patients with cancer- specifically those enrolled in clinical...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Lexington Medical Center

    Lexington Medical Center

    9 days ago

    Nurse practitioner (al)

    Occ Health - Scout Motors PRN Day Shift 6am-6pm Lexington Health is a comprehensive network of care that includes six community medical and urgent care centers, nearly 80 physician practices, more...

    onsite, West Columbia, SC, United States
    Full TimeJunior (<2 years)
  • C

    Charleston Oncology

    11 days ago

    Nurse practitioner – hematology/oncology with bmt & cellular therapy focus

    Nurse Practitioner – Hematology/Oncology with BMT & Cellular Therapy Focus Charleston Oncology | Charleston, SC (with travel to Mount Pleasant) | Full-time No night call You already know how to...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • AnMed

    AnMed

    12 days ago

    Physician assistant/nurse practitioner

    Located in the heart of Anderson, South Carolina, AnMed is a dynamic, not-for-profit health system dedicated to delivering exceptional care with compassion, innovation, and integrity. At AnMed, our...

    onsite, Anderson, SC, United States
    Part TimeJunior (<2 years)
  • Regenesis Health Care

    Regenesis Health Care

    12 days ago

    Psychiatric mental health nurse practitioner

    Why ReGenesis Health Care? At ReGenesis Health Care, you can build a rewarding career while improving access to behavioral health services for patients and families in the Upstate. Our...

    onsite, Spartanburg, SC, United States
    $96k/yrFull TimeJunior (<2 years)
  • Family Health Centers

    Family Health Centers

    12 days ago

    Pediatrics nurse practitioner (floater)

    Join our mission-driven team here at Family Health Centers, Inc., as a Pediatric Nurse Practitioner (Floater). This position provides high-quality, compassionate primary care to pediatric patients...

    onsite, Orangeburg, SC, United States
    $90k/yrFull TimeEntry with Degree
  • Your Health Organization

    Your Health Organization

    12 days ago

    Nurse practitioner - clinic

    We are seeking qualified Nurse Practitioner to service patients in the Grandstrand area. As a Provider, you play a critical role in delivering exceptional patient care in a clinic setting. You are an...

    onsite, Conway, SC, United States
    Full TimeJunior (<2 years)
  • Regenesis Health Care

    Regenesis Health Care

    12 days ago

    Pediatric advanced practice provider (app) – nurse practitioner or physician assistant

    Why ReGenesis Health Care? At ReGenesis Health Care, you can build a rewarding pediatric career while helping expand access to quality health care for children and families throughout our community....

    onsite, Spartanburg, SC, United States
    $96k/yrFull TimeJunior (<2 years)
  • NP Now

    NP Now

    12 days ago

    Psychiatrist nurse practitioner or physician assistant - pmhnp - 10k sign on bonus

    Expanding practice seeks a Psychiatric Nurse Practitioner or Physician Assistant to work in Hartsville, South Carolina! Join a community health organization providing integrated behavioral...

    onsite, Hartsville, SC, United States
    Full TimeJunior (<2 years)
  • Urgent Care Management or Joint Venture Partner

    Urgent Care Management or Joint Venture Partner

    12 days ago

    Nurse practitioner or physician assistant | up to $7,500 sign on bonus

    Up to $7,500 Sign-On Bonus! Limited-time opportunity available to the eligible hires. Bonus eligibility and amount are subject to applicable terms and conditions. Prisma Health Urgent Care seeks...

    onsite, Powdersville, SC, United States
    $8k/yrFull TimeJunior (<2 years)
  • Urgent Care Management or Joint Venture Partner

    Urgent Care Management or Joint Venture Partner

    12 days ago

    Nurse practitioner or physician assistant | part time

    Prisma Health Urgent Care seeks talented, patient-oriented Physician Assistants and Nurse Practitioners who are relentlessly dedicated to ensure the delivery of exceptional customer service by...

    onsite, Clemson, SC, United States
    Full TimeJunior (<2 years)
  • Veterans Health Administration

    Veterans Health Administration

    12 days ago

    Nurse practitioner (cardiology)

    Summary The Nurse Practitioner (NP) serves in Specialty Care/Cardiology, providing Veteran-centered, evidence-based cardiology care with strong team-based collaboration, consultation, and patient...

    onsite, Myrtle Beach, SC, United States
    $109k/yrFull TimeLead / Manager
  • Family Health Centers

    Family Health Centers

    12 days ago

    Nurse practitioner (immediate care)

    Join our mission-driven team here at Family Health Centers, Inc., as a Nurse Practitioner in Immediate Care. This role provides high-quality, patient-centered care for acute illnesses and minor...

    onsite, Orangeburg, SC, United States
    $90k/yrFull TimeJunior (<2 years)
  • Military Treatment Facilities under DHA

    Military Treatment Facilities under DHA

    12 days ago

    Advanced practice nurse (nurse practitioner)

    Summary About the Position: This position in located at the Naval Health Clinic Charleston, Goose Creek, SC within the Medical Home Port/Primary Care Outpatient Clinic. This is a Direct Hire...

    onsite, Goose Creek, SC, United States
    $90k/yrFull TimeJunior (<2 years)
  • PruittHealth

    PruittHealth

    14 days ago

    Regional manager nurse practitioner

    Nurse Practitioner or Physician Assistant NP PA- PruittHealth Premier Services Long Term Care Health Plan - Must be licensed in SC Monday -Friday with Flexibility No Eve or Weekend onsite Required...

    onsite, Charleston, SC, United States
    Full TimeLead / Manager
  • CareATC

    CareATC

    15 days ago

    Nurse practitioner

    At CareATC, we genuinely believe in revolutionizing employer-sponsored healthcare. We're passionate about our mission and deeply committed to providing exceptional, patient-centered solutions for our...

    onsite, Early Branch, SC, United States
    Part TimeJunior (<2 years)
  • Monroe+Biomedical+Research

    Monroe+Biomedical+Research

    17 days ago

    Clinical research nurse practitioner / physician assistant

    ABOUT THE ROLE Monroe Biomedical Research (MBR) is growing, and we are seeking an experienced, patient-focused Clinical Research Nurse Practitioner/Physician Assistant to join our Charleston team....

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Sweetgrass & SouthernMED Pediatrics

    Sweetgrass & SouthernMED Pediatrics

    19 days ago

    Advanced practice provider (nurse practitioner or physician assistant)

    Description What it means to be a Advanced Practice Provider with Us We value our families we serve, our communities and our team members. As an Advanced Practice Provider, you will function...

    onsite, Red Bank, SC, United States
    Full TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    19 days ago

    Nurse practitioner or physician assistant - internal medicine primary care

    Job Description Summary The successful applicant will be an Advanced Practice Provider interested in working full-time in the care of patients in primary care. This APP will have 9 half-day clinic...

    onsite, Mt Pleasant, SC, United States
    Full TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    20 days ago

    Nurse practitioner or physician assistant - pediatrics hematology & oncology

    Job Description Summary The Department of Pediatrics, Division of Pediatric Hematology & Oncology is recruiting for an Advanced Practice Provider (NP/PA) to work full time primarily in the Pediatric...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    20 days ago

    Nurse practitioner or physician assistant - primary care

    Job Description Summary The successful applicant will be an Advanced Practice Provider interested in working part-time in the care of patients in primary care. This APP will have 4.5 half-day clinic...

    onsite, Mt. Pleasant, SC, United States
    Part TimeJunior (<2 years)
  • PruittHealth

    PruittHealth

    20 days ago

    Nurse practitioner np hospice and palliative care

    NURSE PRACTITIONER (ARNP) - HOSPICE SERVICES Join the PruittHealth Hospice family, where the health and safety of our workforce is our top priority! We're not only committed to your career, we're...

    onsite, Anderson, SC, United States
    Full TimeJunior (<2 years)
  • Cherokee Federal

    Cherokee Federal

    20 days ago

    Nurse practitioner, aprn, fnp

    A government contract requires that this position be restricted to U.S. citizens. This position requires a Common Access Card (CAC), and the ability to pass the U.S. Department of Defense (DoD)...

    onsite, Charlotte, NC, United States
    $120k – $130k/yrFull TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    21 days ago

    Nurse practitioner- emergency medicine - greenville

    Inspire health. Serve with compassion. Be the difference. Job Summary Works under the supervision of a physician to give quality treatment, referral and follow-up care in a surgical specialty or...

    onsite, Greenville, SC, United States
    Full TimeEntry with Degree
  • Wellpath

    Wellpath

    23 days ago

    Psychiatric nurse practitioner - part-time

    You Matter Make a difference every day in the lives of the underserved Join a mission driven organization with a people first culture Excellent career growth opportunities Join us and find a career...

    onsite, Newport, SC, United States
    Part TimeJunior (<2 years)
  • Tenet Healthcare Corporation

    Tenet Healthcare Corporation

    a month ago

    Nurse practitioner - primary care - rock hill, sc

    Piedmont Physician Network is seeking a full-time Nurse Practitioner or Physician Assistant to join a growing Primary Care practice in Rock Hill, South Carolina. This outpatient-based role offers the...

    onsite, Rock Hill, SC, United States
    Full TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    a month ago

    Nurse practitioner or physician assistant - hospital medicine

    Job Description Summary The successful applicant will be an Advanced Practice Provider interested in working full-time in the care of patients on various different Hospital Medicine service lines....

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Agape Care Group

    Agape Care Group

    a month ago

    Nurse practitioner (np) palliative care

    Overview Join Our Team as a Hospice and Palliative Care Nurse Practitioner Do you value the time you spend with patients? Are you committed to providing quality, compassionate care? We are looking...

    onsite, Greenwood, SC, United States
    Full TimeJunior (<2 years)
  • Lexington Medical Center

    Lexington Medical Center

    a month ago

    Nurse practitioner (cmc)

    LH Irmo Urgent Care PRNAM/PM Shift 8a-8p Lexington Health is a comprehensive network of care that includes six community medical and urgent care centers, nearly 80 physician practices, more than...

    onsite, West Columbia, SC, United States
    Full TimeEntry with Degree

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