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  2. Kentucky
  3. Louisville
  4. Nurse Practitioner

Onsite Nurse Practitioner jobs in Louisville, Kentucky, USA

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      Sarah Jenkins

    • 2:30 PM - 3:00 PM

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      Alex Chen

  • Mon
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      David G. (Hiring Manager)

    • 4:15 PM - 5:15 PM

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      Sophie L.

  • Tue
    • 1:20 PM - 1:45 PM

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      Marta W.

    • 2:30 PM - 3:00 PM

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      Daria (HR)

  • Wed
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      Qualifying Interview

      James Miller

    • 5:30 PM - 6:00 PM

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      Chris V.

  • Thu
    • 2:30 PM - 3:00 PM

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      Michael T.

    • 4:00 PM - 5:00 PM

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Nurse Practitioner Jobs in Louisville: On-Site Roles Shaping Modern Healthcare

Louisville's healthcare network continues to expand, creating strong demand for skilled nurse practitioners who thrive in on-site clinical settings. With 203 open positions available, local hospitals and clinics are actively seeking professionals ready to deliver high-quality patient care. This growth reflects a broader national trend in nurse practitioner jobs in Louisville, as communities invest in accessible, patient-centered medicine.

Successful candidates bring a blend of clinical expertise, compassionate communication, and sound clinical judgment to every patient interaction. Employers look for strong diagnostic skills, proficiency with electronic health records, and the ability to collaborate across multidisciplinary teams. A current license, board certification, and a commitment to evidence-based practice remain essential, while adaptability and leadership set top nurse practitioner vacancies apart in a competitive market.

On-site work in Louisville allows clinicians to build lasting relationships with patients and care teams, something remote formats can't replicate. Hospitals, urgent care centers, and private practices throughout Kentucky continue to hire a nurse practitioner to meet rising patient volumes and support preventive care initiatives. The regional outlook remains favorable, with steady job growth expected across both urban and suburban healthcare facilities.

If you're ready to make a meaningful impact in patient care, explore the latest nurse practitioner positions available through Global Work AI. Our platform connects dedicated professionals with employers who value expertise, compassion, and dedication. Take the next step in your career and discover opportunities that align with your skills and ambitions today.

Frequently Asked
Questions

Everything you need to know about
finding your next role
  • What is the average nurse practitioner salary in Louisville?

    Pay for a nurse practitioner in Louisville, Kentucky often lands in the low-to-mid six figures, with many employers advertising roughly $105,000 to $130,000 a year depending on specialty, experience, and schedule. Hospitals, primary care groups, and urgent care sites may also add differentials, bonuses, or benefits that change total compensation. Local market rates can shift with demand across the Louisville metro area, so comparing current openings and pay bands is the best way to gauge what is realistic for your background and practice setting.
  • What qualifications are needed to become a nurse practitioner in Kentucky?

    A strong route into this role starts with an RN license, a graduate degree in nursing, and advanced clinical training in a population focus such as family, acute care, or psychiatric-mental health. In Kentucky, employers typically look for national board certification, supervised clinical hours, and evidence of safe, patient-centered practice. Many job postings in Louisville also prefer prior bedside or outpatient experience. Because expectations vary by specialty, it helps to compare educational pathways with the exact clinical area you want to enter.
  • Is an active Kentucky APRN license required for a nurse practitioner job in Louisville?

    For most nurse practitioner jobs in Louisville, yes—an active Kentucky APRN license is generally required before you can begin work. Employers also commonly expect current RN licensure in Kentucky and national certification tied to your role. Some systems may review applications before licensure is finalized, but clinical practice usually cannot start until all state credentials are active and in good standing. Since regulations and facility policies can differ, review each posting carefully and confirm the license status expected for that specific setting.
  • What are the main responsibilities of a nurse practitioner in an on-site clinical setting?

    Day-to-day work in an on-site clinic usually includes assessing patients, ordering and interpreting tests, diagnosing common and complex conditions, and creating treatment plans. A nurse practitioner in Louisville may also prescribe medications, coordinate care with physicians and other clinicians, document visits in the EHR, and educate patients on prevention and follow-up. The exact scope depends on the department, site policies, and Kentucky practice rules. Reviewing the department type is useful, since responsibilities can look quite different in primary care, urgent care, or specialty practice.
  • What skills are most important for a nurse practitioner working with patients?

    Clinical judgment is essential, but strong communication often matters just as much in direct patient care. Employers in Louisville look for careful assessment skills, accurate documentation, empathy, time management, and the ability to explain treatment clearly to people from varied backgrounds. Collaboration is important too, since most on-site teams rely on smooth coordination with nurses, physicians, and support staff. Adaptability helps when schedules are full or cases are complex, so it is useful to match your strengths with the clinical environment before applying.
  • What is the hiring process for nurse practitioner jobs in Louisville?

    Most hiring steps begin with an online application, followed by resume review, credential screening, and one or more interviews with clinical leaders or hiring managers. For a nurse practitioner role in Louisville, employers often verify Kentucky licensure, certification, work history, and references before extending an offer. Final stages may include background checks, health clearances, and onboarding paperwork. Timelines vary by employer and specialty, so it helps to watch for updates in the job description and compare similar local postings to understand typical pace.
  • What career growth opportunities are available for nurse practitioners in Kentucky?

    Kentucky offers several paths for advancement, especially in larger markets like Louisville where hospitals, specialty practices, and outpatient networks create diverse experience. A nurse practitioner may grow into lead APP roles, specialty care positions, clinical education, quality improvement, or administrative leadership. Some professionals also expand into telehealth, research, or academic work, depending on their background. Additional certifications can strengthen mobility across settings. Exploring different departments and comparing regional employers can help you see which direction best matches your long-term goals.

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203 jobs found

  • Trilogy Health Services, LLC

    Trilogy Health Services, LLC

    a day ago

    Nurse director in training

    JOIN TEAM TRILOGY Weekly pay, health and dental after your first month, student loan repayment, a competitive 401(k) match, and more! Make a living while you make a difference at Trilogy Health...

    onsite, Louisville, KY, United States
    Full TimeDirector
  • Seven Counties Services

    Seven Counties Services

    a day ago

    Family nurse practitioner - addictions residential

    Job Description: ESSENTIAL JOB FUNCTIONS Provides psychiatric clinical services to children, including evaluation, follow-up, medication, emergency/crisis intervention, telephone consultation, etc....

    onsite, Louisville, KY, United States
    Full TimeMiddle (2-4 years)
  • Seven Counties Services

    Seven Counties Services

    a day ago

    Registered nurse or licensed practical nurse - outpatient prn

    Job Description: ESSENTIAL JOB FUNCTIONS Administers and oversees self-administered and prescribed medications per established schedules as ordered. Monitors clients' vital signs and other physical...

    onsite, Louisville, KY, United States
    Part TimeSenior (5+ years)
  • DAVITA

    DAVITA

    a day ago

    Registered nurse

    Posting Date 10/19/2026 720 W Broadway, Louisville, Kentucky, 40202, United States of America Make a real impact—every day. As a DaVita RN, you’ll ensure compassionate and professional delivery of...

    onsite, Louisville, KY, United States
    Full TimeJunior (<2 years)
  • Signature HealthCARE, LLC

    Signature HealthCARE, LLC

    2 days ago

    Registered nurse (rn)

    About Us Signature HealthCARE of South Louisville is a 100-bed facility offering a broad range of services, from short-term and long-term skilled care and intermediate care to inpatient and...

    onsite, Louisville, KY, United States
    $90k/yrFull TimeJunior (<2 years)
  • BHS

    BHS

    2 days ago

    Registered nurse nicu prn nights

    Summary Job Description: Registered Nurse NICU- PRN, Nights Status: PRN Shift: Third About the Unit: The NICU provides level III care to infants as early as 26 weeks gestation. NICU is comprised of...

    onsite, Louisville, KY, United States
    Part TimeJunior (<2 years)
  • Lifepoint Health

    Lifepoint Health

    3 days ago

    Registered nurse, rehabilitation

    Join our Remarkable Team! Location – Louisville, KY Schedule – Full Time Days 7a-7p Your experience matters U of L Rehab Hospital Frazier Brownsboro is part of Lifepoint Health, a diversified...

    onsite, Louisville, KY, United States
    Full TimeJunior (<2 years)
  • Trilogy Health Services, LLC

    Trilogy Health Services, LLC

    4 days ago

    Licensed practical nurse (lpn)

    JOIN TEAM TRILOGY At Trilogy, you’ll experience a caring, supportive community that values each team member. We prioritize meaningful relationships, genuine teamwork, and continuous growth. With the...

    onsite, Louisville, KY, United States
    Part TimeJunior (<2 years)
  • BHS

    BHS

    4 days ago

    Charge nurse part time, nights- 5 south observation

    Job Summary The 5 South Observation Unit supports both the Emergency Department and telemetry services by caring for low‑acuity patients who require short‑term monitoring to determine whether...

    onsite, Louisville, KY, United States
    Part TimeJunior (<2 years)
  • BrightView LLC

    BrightView LLC

    5 days ago

    Nurse practitioner

    Overview BrightView was founded to give the people in our communities two things: help and hope. We’re changing addiction treatment by combating the disease of addiction with a comprehensive...

    onsite, Louisville, KY, United States
    Full TimeJunior (<2 years)
  • Everent Health & Affiliates

    Everent Health & Affiliates

    6 days ago

    Clinical nurse (rn) manager

    Hosparus Health starts with a compassionate team, committed to our mission of creating more moments for our patients facing advanced illness or end of life care. Our premier model of care supports...

    onsite, Louisville, KY, United States
    Full TimeMiddle (2-4 years)
  • Fresenius Medical Care

    Fresenius Medical Care

    6 days ago

    New graduate nurse

    PURPOSE AND SCOPE: Functions as part of the hemodialysis health care team as a Registered Nurse Applicant, under the direction or supervision of a Staff Registered Nurse, to ensure provision of...

    onsite, Louisville, KY, United States
    Full TimeJunior (<2 years)
  • UofL Health

    UofL Health

    7 days ago

    Nurse navigator bone health

    Primary Location: JHHS - Med Center NE - ULP - CMG Address: 2401 Terra Crossing Blvd Louisville, KY 40241 Shift: Salary Shift (United States of America) Job Description Summary: UofL Health is a...

    onsite, Louisville, KY, United States
    Full TimeJunior (<2 years)
  • TwelveStone Health Partners Inc

    TwelveStone Health Partners Inc

    8 days ago

    Nurse practitioner – infusion center (float)

    The TwelveStone Infusion Centers LLC, manages the Infusion needs of patient’s and maintains the continuum of care, from intake, assessment, and treatment through the completion of their visit. Our...

    onsite, Louisville, KY, United States
    Full TimeJunior (<2 years)
  • Signature HealthCARE, LLC

    Signature HealthCARE, LLC

    9 days ago

    Hiring event - licensed practical nurse (lpn)

    About Us Signature HealthCARE at Summerfield Rehab & Wellness Center is a 165-bed facility that offers a wide array of services from short-term rehabilitation to traditional long-term care. It is our...

    onsite, Louisville, KY, United States
    $65k/yrFull TimeEntry with Degree
  • BHS

    BHS

    9 days ago

    Nurse practitioner/physician assistant - urgent care prn - louisville, kentucky

    Summary Job Description: Job Summary The Baptist Health Medical Group (BHMG) APP reflects the mission, vision, and values of BHMG adheres to the organization’s Code of Ethics and Corporate Compliance...

    onsite, Louisville, KY, United States
    Part TimeEntry with Degree
  • Fresenius Medical Care

    Fresenius Medical Care

    9 days ago

    Dialysis clinical manager registered nurse - rn

    About this role: As a Clinical Manager with Fresenius Medical Care, you will ensure that quality patient care is delivered while maintaining clinical operations. As the facility leader, you will be...

    onsite, Louisville, KY, United States
    Full TimeJunior (<2 years)
  • DaVita Kidney Care

    DaVita Kidney Care

    9 days ago

    Registered nurse

    Posting Date 10/19/2026 720 W Broadway, Louisville, Kentucky, 40202, United States of America Make a real impact—every day. As a DaVita RN, you’ll ensure compassionate and professional delivery of...

    onsite, Louisville, KY, United States
    Full TimeJunior (<2 years)
  • Venza Care Management

    Venza Care Management

    10 days ago

    Registered nurse (rn) unit manager

    Are you a dedicated and experienced Registered Nurse (RN) with a passion for leading and supporting a clinical team? Do you excel in a leadership role where you can make a significant impact on...

    onsite, Louisville, KY, United States
    $75k – $85k/yrFull TimeJunior (<2 years)
  • TRITAL Care

    TRITAL Care

    11 days ago

    Registered nurse (rn) - prn

    About the Role We are seeking qualified Registered Nurses for PRN assignments across multiple hospital units and clinical specialties in Louisville, Kentucky. Nurses will provide patient-centered...

    onsite, Louisville, KY, United States
    Part TimeJunior (<2 years)
  • Kindred Healthcare

    Kindred Healthcare

    11 days ago

    Registered nurse full-time nights

    Job Summary Provides planning and delivery of direct and indirect patient care through the nursing process of Assessment, Planning, Intervention, and Evaluation. Develops nursing care plans in...

    onsite, Louisville, KY, United States
    Full TimeJunior (<2 years)
  • Career Center

    Career Center

    12 days ago

    Nurse practitioner

    Ready to Make a Difference in Healthcare? At TruHealth, we’re transforming care for seniors in long-term care with an innovative, proactive model that promotes dignity, independence, and quality of...

    onsite, Louisville, KY, United States
    Full TimeMiddle (2-4 years)
  • Volunteers of America National Services

    Volunteers of America National Services

    12 days ago

    Nurse practitioner

    Care with Heart. Work with Purpose. Join The Senior Community Care of Kentucky PACE as a Nurse Practitioner in Louisville, KY (Jefferson County). This is more than a job! It’s a paid opportunity to...

    onsite, Louisville, KY, United States
    $118k – $134k/yrFull TimeJunior (<2 years)
  • BHS

    BHS

    13 days ago

    Mixed acuity critical care charge nurse part time days

    Summary Job Description: Part Time 24 weekly hours, day shift - two 12-hour shifts 7A-7P Sign on Bonus eligible for experienced candidates! Critical Care Mixed Acuity Unit Mixed Acuity Unit is both a...

    onsite, Louisville, KY, United States
    Part TimeJunior (<2 years)
  • Kindred Healthcare

    Kindred Healthcare

    14 days ago

    Registered nurse, ft nights

    Kindred Hospital Louisville is a 123-bed long-term acute care hospital offering the same in-depth care you would receive in a traditional hospital, but for an extended recovery period; including 16...

    onsite, Louisville, KY, United States
    Full TimeJunior (<2 years)
  • Seven Counties Services

    Seven Counties Services

    14 days ago

    Integrated care coordinator (nurse)

    Job Description: ESSENTIAL JOB FUNCTIONS Provides first point of clinic contact for all new clients. Explain services available and focus on engagement of client to access services. Completes health...

    onsite, Louisville, KY, United States
    Full TimeMiddle (2-4 years)
  • Concentra

    Concentra

    18 days ago

    Physician assistant or nurse practitioner prn

    Overview Are you ready to take your career to new heights? At Concentra, you will be a vital member of our patient care team and play a crucial role in providing exceptional care to our patients. Our...

    onsite, Louisville, KY, United States
    Full TimeJunior (<2 years)
  • UofL Health

    UofL Health

    18 days ago

    Nurse manager, brown cancer center downtown, oncology, 7:30a-4:p

    Primary Location: UofL Health - Brown Cancer Center - UMC Address: 529 S. Jackson St. Louisville, KY 40202 Shift: First Shift (United States of America) Job Description Summary: UofL Health is a...

    onsite, Louisville, KY, United States
    Full TimeMiddle (2-4 years)
  • Concentra

    Concentra

    19 days ago

    Nurse practitioner or physician assistant prn

    Overview This PRN role is for nights only 7pm to 7am Are you ready to take your career to new heights? At Concentra, you will be a vital member of our patient care team and play a crucial role in...

    onsite, Louisville, KY, United States
    Full TimeJunior (<2 years)
  • Volunteers of America National Services (VOANS)

    Volunteers of America National Services (VOANS)

    19 days ago

    Nurse practitioner

    Care with Heart. Work with Purpose. Join The Senior Community Care of Kentucky PACE as a Nurse Practitioner in Louisville, KY. This is more than a job! It’s a paid opportunity to serve others, live...

    onsite, Louisville, KY, United States
    $118k – $134k/yrFull TimeJunior (<2 years)
  • BHS

    BHS

    19 days ago

    Critical care mixed acuity charge nurse full time days

    Summary Job Description: Full Time 36 weekly hours, nights - three 12-hour shifts per week, (7P-7:30A) & every 3rd weekend - holidays and weekends per unit needs Sign on Bonus eligible for...

    onsite, Louisville, KY, United States
    Full TimeEntry with Degree
  • Lifepoint Health

    Lifepoint Health

    21 days ago

    Registered nurse, (rn) rehabilitation (ft nights)

    Join our Remarkable Team! Location – Louisville, KY Schedule – Full Time Nights 7p-7a Your experience matters U of L Rehab Hospital Frazier Brownsboro is part of Lifepoint Health, a diversified...

    onsite, Louisville, KY, United States
    Full TimeJunior (<2 years)
  • Proactive MD

    Proactive MD

    24 days ago

    Prn family nurse practitioner

    PRN Family Nurse Practitioner Flexible weekday PRN opportunities with Proactive MD Are you a Nurse Practitioner looking for meaningful clinical work with the flexibility of a PRN schedule? At...

    onsite, Jeffersonville, IN, United States
    Part TimeJunior (<2 years)
  • Isaiah House Inc

    Isaiah House Inc

    24 days ago

    Registered nurse - prn

    Come for the career. Stay for the mission. Change lives along the way. Isaiah House is a nonprofit, Christ-centered addiction recovery organization serving individuals and families across Kentucky....

    onsite, Louisville, KY, United States
    Part TimeJunior (<2 years)
  • Fresenius Medical Care

    Fresenius Medical Care

    a month ago

    Outpatient licensed practical nurse - lpn lvn

    Provide your personal attention and kindness, professional insight, and a generosity of spirit. Offer expertise and encouragement. Enhance each patient's future-as well as your own. Connect with your...

    onsite, Louisville, KY, United States
    Full TimeJunior (<2 years)
  • UofL Health

    UofL Health

    a month ago

    Rapid response nurse merit, uofl hospital, 7p-7a

    Primary Location: University Hospital - UMC Address: 530 South Jackson Street Louisville, KY 40202 Shift: Nights 7P - 7A (United States of America) Job Description Summary: UofL Health is a fully...

    onsite, Louisville, KY, United States
    Full TimeJunior (<2 years)
  • Trilogy Health Services, LLC

    Trilogy Health Services, LLC

    a month ago

    Registered nurse (rn)

    JOIN TEAM TRILOGY At Trilogy, you’ll experience a caring, supportive community that values each team member. We prioritize meaningful relationships, genuine teamwork, and continuous growth. With the...

    onsite, Louisville, KY, United States
    Part TimeJunior (<2 years)
  • FIRST UROLOGY P S C

    FIRST UROLOGY P S C

    a month ago

    Men's health clinic - nurse practitioner

    Job Details Salary Range: Undisclosed Location(s): Kentucky Job Type: Full Time, Non-Exempt Schedule: 4 days a week First Urology is the largest independent urology practice serving Louisville,...

    onsite, Louisville, KY, United States
    Full TimeMiddle (2-4 years)
  • Veterans Health Administration

    Veterans Health Administration

    a month ago

    Advanced practice nurse-clinical operations

    Summary Robley Rex Department of Veterans Affairs Medical Center, Louisville, Kentucky is currently recruiting for an Advanced Practice Nurse-Clinical Chief Operations Louisville, Kentucky. Duties...

    onsite, Louisville, KY, United States
    $143k/yrFull TimeLead / Manager
  • Home of the Innocents

    Home of the Innocents

    a month ago

    Assistant nurse manager

    Are you an experienced RN who leads naturally, someone who can step into a clinical challenge and lift your whole team in the process? Home of the Innocents is seeking an Assistant Nurse Manager to...

    onsite, Louisville, KY, United States
    Full TimeLead / Manager

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