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  1. Onsite Jobs
  2. South Carolina
  3. Columbia
  4. Registered Nurse

Onsite Registered Nurse jobs in Columbia, South Carolina, USA

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  • Sun
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      Senior Product Manager Interview

      Sarah Jenkins

    • 2:30 PM - 3:00 PM

      Initial Interview

      Alex Chen

  • Mon
    • 11:00 AM - 11:15 AM

      Product Manager Interview

      David G. (Hiring Manager)

    • 4:15 PM - 5:15 PM

      First Round Interview

      Sophie L.

  • Tue
    • 1:20 PM - 1:45 PM

      Introductory Interview

      Marta W.

    • 2:30 PM - 3:00 PM

      Kick-off Interview

      Daria (HR)

  • Wed
    • 1:00 PM - 1:45 PM

      Qualifying Interview

      James Miller

    • 5:30 PM - 6:00 PM

      Discovery Interview

      Chris V.

  • Thu
    • 2:30 PM - 3:00 PM

      First Interview

      Michael T.

    • 4:00 PM - 5:00 PM

      Interview

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Registered Nurse Jobs in Columbia: On-Site Opportunities for Dedicated Caregivers

Columbia's healthcare sector continues to expand, creating strong demand for skilled nursing professionals across hospitals and clinics. Facilities throughout the city are actively looking to fill 218 on-site positions, reflecting the steady growth of Registered Nurse jobs in Columbia. This on-site role offers an opportunity to make a direct impact on patient care within a supportive community setting.

Successful candidates bring strong clinical judgment, compassionate bedside manner, and the ability to thrive in fast-paced environments. Employers seek nurses with solid knowledge of patient assessment, medication administration, and electronic health record systems, along with excellent communication and teamwork skills. Current licensure, CPR certification, and a commitment to continuous learning are essential, while experience in acute care or specialty units is a valuable asset for those pursuing Registered Nurse positions in this region.

On-site work remains the standard for registered nurse roles in Columbia, as hands-on patient interaction defines the profession. Local hospitals, outpatient centers, and long-term care facilities consistently hire a registered nurse to meet growing community health needs, making this an encouraging market for job seekers. South Carolina's healthcare industry shows steady expansion, reinforcing long-term career stability for nursing professionals in the area.

If you're ready to advance your nursing career in a dynamic, patient-focused environment, now is the perfect time to explore Registered Nurse vacancies in Columbia. Global Work AI connects dedicated healthcare professionals with rewarding opportunities that match their skills and ambitions. Take the next step toward a fulfilling career by discovering what awaits in this thriving healthcare community.

Frequently Asked
Questions

Everything you need to know about
finding your next role
  • What is the average salary for a registered nurse in Columbia, SC?

    In Columbia, SC, compensation for a registered nurse typically falls within a mid-range Southern market, with pay influenced by hospital system, specialty, years of experience, and shift differential. Recent wage data for South Carolina generally places registered nurse earnings around the low-to-mid $70,000s annually, while Columbia openings may run a bit higher in acute care or high-demand units. Benefits such as tuition support, retirement plans, and differentials can meaningfully raise total value. Reviewing current Columbia listings is the best way to compare base pay with package details.
  • What qualifications and RN license are required for a registered nurse job in South Carolina?

    Most employers in South Carolina expect an accredited nursing degree, successful completion of the NCLEX-RN, and an active South Carolina RN license or compact multistate privilege if eligibility applies. In many Columbia facilities, prior clinical experience, BLS certification, and specialty credentials can strengthen an application, especially for med-surg, ICU, or emergency care. Background checks, immunization records, and health screenings are also common before hire. Since requirements vary by unit, it helps to compare postings and board standards together before applying.
  • What are the main responsibilities of a registered nurse in a hospital or clinical setting?

    Day-to-day work usually centers on patient assessment, medication administration, care planning, documentation, and close coordination with physicians and other care teams. In a hospital or outpatient clinic in Columbia, SC, a registered nurse may also monitor vital signs, educate patients and families, prepare for procedures, and respond quickly to changes in condition. Accurate charting and safe handoff communication are essential across every shift. The exact duties depend on the department, so reviewing unit-specific descriptions can clarify expectations.
  • What nursing skills are most important for a registered nurse position?

    Strong clinical judgment matters, but so do communication, organization, and calm decision-making under pressure. For a registered nurse role in Columbia, SC, employers often look for IV therapy competence, medication safety, assessment skills, and the ability to prioritize several patients at once. Compassion, teamwork, and clear documentation are equally important in busy hospital and clinic environments. Familiarity with electronic health records is also valuable. If you are comparing roles, look closely at which skills are emphasized most by each employer.
  • How does the hiring process usually work for a registered nurse job in Columbia, SC?

    The process often starts with an online application, followed by recruiter screening, an interview with nursing leadership, and verification of licensure and credentials. In Columbia, SC, many health systems also include reference checks, background screening, drug testing, and sometimes a skills or behavioral interview focused on patient scenarios. Some employers move quickly for acute care openings, especially when staffing needs are urgent. Afterward, onboarding usually covers unit orientation, compliance training, and policy review, so it helps to track timelines across similar listings.
  • What shift schedules and on-call expectations are common for on-site registered nurse roles?

    Most on-site registered nurse positions follow 8-, 10-, or 12-hour shifts, with nights, weekends, and holidays often rotated among staff. In Columbia, SC, hospitals commonly rely on 12-hour schedules for inpatient units, while clinics may use daytime hours with fewer off-hours demands. On-call expectations vary by specialty; surgical, labor and delivery, and some procedural teams may need availability outside the standard shift. Always check whether the posting includes shift differentials or rotating coverage before comparing opportunities.
  • What career growth opportunities are available for registered nurses in South Carolina?

    South Carolina offers solid pathways for advancement, especially in larger health systems and academic medical centers. A registered nurse in Columbia may move into charge nurse, preceptor, case management, quality improvement, or nurse educator roles, or pursue specialty certification in areas like critical care, oncology, or perioperative nursing. Many employers also support bridge programs for BSN or graduate study, which can open doors to advanced practice or leadership tracks. If long-term growth matters, it is worth comparing roles by training support and promotion history.

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218 jobs found

  • Life Care Center of Columbia SC

    Life Care Center of Columbia SC

    Today

    Registered nurse (rn) supervisor

    Position Summary The RN Supervisor is responsible for the coordination of the patient’s care and services. Promotes quality care using a collaborative process that coordinates, monitors, and...

    onsite, Columbia, SC, United States
    Part TimeLead / Manager
  • Medical University of South Carolina

    Medical University of South Carolina

    Today

    Registered nurse - medsurg ne

    Job Description Summary Under general supervision, the Registered Nurse provides individualized, goal-directed patient care to families and patients at a competent level utilizing the principles and...

    onsite, Columbia, SC, United States
    $60k/yrFull TimeJunior (<2 years)
  • CenterWell

    CenterWell

    a day ago

    Home health registered nurse

    Become a part of our caring community As a CenterWell Home Health nurse, reporting to the Clinical Manager, you will provide personalized, one-on-one care that helps patients regain independence in...

    onsite, Columbia, SC, United States
    $77k – $106k/yrFull TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    3 days ago

    Registered nurse (rn)-acute care, family beginnings mother baby, ft, nights

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Armor Health

    Armor Health

    4 days ago

    Day registered nurse (rn)

    Overview Excellent outcomes start with great people, and Armor has an exciting opportunity for a Registered Nurse (RN) to join our team. Why Should You Choose Us? Join an organization with...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • AdamsPlace

    AdamsPlace

    7 days ago

    Rn registered nurse

    Position: Registered Nurse (RN) Are you looking to make a difference in the lives of others by sharing your care and compassion? Do you enjoy connecting with your patients while getting to know them...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • DaVita Kidney Care

    DaVita Kidney Care

    8 days ago

    Registered nurse

    Posting Date 10/20/2026 4450 Rosewood Dr, Columbia, South Carolina, 29209, United States of America DaVita is seeking a Registered Nurse to join our outpatient dialysis team. In this role, you'll...

    onsite, Columbia, SC, United States
    Full TimeEntry with Degree
  • BAYADA Home Health Care

    BAYADA Home Health Care

    9 days ago

    Registered nurse (rn)

    Fall Into Purpose-Driven Nursing with BAYADA Our Columbia Skilled Office is interested in a Registered Nurse (RN) who has a passion for home care to join our Skilled Private Duty Nursing team. We...

    onsite, Columbia, SC, United States
    $60k – $65k/yrPart TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    10 days ago

    Registered nurse (rn) - acute care, surgical trauma, ft, days

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    12 days ago

    Registered nurse (rn)-ambulatory, psychiatry, ft, day

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides and coordinates nursing care in a non-acute ambulatory, medical office, or urgent care setting in accordance with the...

    onsite, Columbia, SC, United States
    Full TimeEntry with Degree
  • Prisma Health

    Prisma Health

    13 days ago

    Registered nurse (rn) - acute care, level i emergency trauma center, ft, nights

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • AdamsPlace

    AdamsPlace

    13 days ago

    Registered nurse, rn

    Position: Registered Nurse, RN Pay: $70000 - $77000 / yearly Depending On Experience Caris Healthcare RN provides nursing care to patients per the physician’s orders. The hallmarks of this position...

    onsite, Columbia, SC, United States
    $70k – $77k/yrFull TimeJunior (<2 years)
  • Physicians Dialysis

    Physicians Dialysis

    14 days ago

    Registered nurse

    GENERAL PURPOSE OF THE JOB: The individual in this role assumes direct responsibility and accountability for the care of chronic dialysis patients as well as oversight of unlicensed assistive staff...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    14 days ago

    Registered nurse (rn)-clinical nurse educator i, ft, days

    Inspire health. Serve with compassion. Be the difference. Job Summary Responsible for preparing the healthcare workforce for the clinical setting by teaching competency-based curriculum programs....

    onsite, Columbia, SC, United States
    Full TimeMiddle (2-4 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    15 days ago

    Registered nurse -pcu

    Job Description Summary Under general supervision, the Registered Nurse II provides individualized, goal-directed patient care to families and patients at a competent level utilizing the principles...

    onsite, Columbia, SC, United States
    $60k/yrFull TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    15 days ago

    Registered nurse -prn ne

    Job Description Summary Under general supervision, the Registered Nurse II provides individualized, goal-directed patient care to families and patients at a competent level utilizing the principles...

    onsite, Columbia, SC, United States
    $105k/yrPart TimeJunior (<2 years)
  • PruittHealth

    PruittHealth

    15 days ago

    Registered nurse

    REGISTERED NURSE - Full Time Join the PruittHealth family, where the health and safety of our workforce is our top priority! We're not only committed to your career, we're committed to the health and...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    16 days ago

    Registered nurse (rn) - ambulatory, internal resource pool, ft, days

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an ambulatory setting under the direction of the physician,...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    17 days ago

    Registered nurse (rn) - acute care, level i general surgery operating room, ft, days

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    17 days ago

    Registered nurse (rn)-acute care, icu intermediate, ft, varied shifts

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    17 days ago

    Registered nurse (rn)-acute care, icu / stepdown, pt, nights

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Columbia, SC, United States
    Part TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    17 days ago

    Registered nurse (rn) - acute care, level i emergency trauma center, ft, days

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    21 days ago

    Registered nurse ii - csr

    Job Description Summary Under general supervision, the Registered Nurse II provides individualized, goal-directed patient care to families and patients at the competent level utilizing the principles...

    onsite, Columbia, SC, United States
    $36k/yrFull TimeMiddle (2-4 years)
  • Agape Care Group

    Agape Care Group

    22 days ago

    Registered nurse (rn)

    Overview Join Our Team as a Registered Nurse Do you value the time you spend with your patients? Is it important to you that your patients and their families know and feel that you are with them? We...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Agape Care Group

    Agape Care Group

    22 days ago

    Registered nurse (rn) after hours - weekends

    Overview Join Our Team as a Registered Nurse Do you value the time you spend with your patients? Is it important to you that your patients and their families know and feel that you are with them? We...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    22 days ago

    Registered nurse ii- prn nights -stu

    Job Description Summary Under general supervision, the Registered Nurse provides individualized, goal-directed patient care to families and patients at a competent level utilizing the principles and...

    onsite, Columbia, SC, United States
    Part TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    22 days ago

    Registered nurse ii - rn newborn nursery (part-time)

    Job Description Summary Under general supervision, the Registered Nurse II provides individualized, goal-directed patient care to families and patients at the competent level utilizing the principles...

    onsite, Columbia, SC, United States
    $52k/yrPart TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    22 days ago

    Registered nurse ii- medsurg - ne prn

    Job Description Summary Under general supervision, the Registered Nurse provides individualized, goal-directed patient care to families and patients at a competent level utilizing the principles and...

    onsite, Columbia, SC, United States
    $105k/yrPart TimeMiddle (2-4 years)
  • PruittHealth

    PruittHealth

    24 days ago

    Registered nurse-prn

    REGISTERED NURSE-PRN Join the PruittHealth family, where the health and safety of our workforce is our top priority! We're not only committed to your career, we're committed to the health and safety...

    onsite, Columbia, SC, United States
    Part TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    24 days ago

    Registered nurse (rn) - acute care, mental health emergency department, ft, day

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    a month ago

    Registered nurse (rn) - nurse resident, winter 2027, laurel oaks, med/surg

    Inspire health. Serve with compassion. Be the difference. Job Summary Responsible for attending all quality and core curriculum classes, actively participating in professional development workshops...

    onsite, Columbia, SC, United States
    Full TimeEntry with Degree
  • Prisma Health

    Prisma Health

    a month ago

    Registered nurse (rn)-ambulatory, cardiac rehab, ft

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides routine, standardized nursing care for patients under the supervision of the physician. Bonus This position is bonus...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    a month ago

    Registered nurse (rn) - nurse resident, winter 2027, cardiac telemetry

    Inspire health. Serve with compassion. Be the difference. Job Summary Responsible for attending all quality and core curriculum classes, actively participating in professional development workshops...

    onsite, Columbia, SC, United States
    Full TimeEntry with Degree
  • Prisma Health

    Prisma Health

    a month ago

    Registered nurse (rn) - nurse resident, winter 2027, ltac, long-term acute care

    Inspire health. Serve with compassion. Be the difference. Job Summary Responsible for attending all quality and core curriculum classes, actively participating in professional development workshops...

    onsite, Columbia, SC, United States
    Full TimeEntry with Degree
  • Prisma Health

    Prisma Health

    a month ago

    Registered nurse (rn) - nurse resident, winter 2027, intermediate icu

    Inspire health. Serve with compassion. Be the difference. Job Summary Responsible for attending all quality and core curriculum classes, actively participating in professional development workshops...

    onsite, Columbia, SC, United States
    Full TimeMiddle (2-4 years)
  • Prisma Health

    Prisma Health

    a month ago

    Registered nurse (rn) - nurse resident, winter 2027, medical telemetry

    Inspire health. Serve with compassion. Be the difference. Job Summary Responsible for attending all quality and core curriculum classes, actively participating in professional development workshops...

    onsite, Columbia, SC, United States
    Full TimeEntry with Degree
  • Prisma Health

    Prisma Health

    a month ago

    Registered nurse (rn) - nurse resident, winter 2027, surgical specialty

    Inspire health. Serve with compassion. Be the difference. Job Summary Responsible for attending all quality and core curriculum classes, actively participating in professional development workshops...

    onsite, Columbia, SC, United States
    Full TimeEntry with Degree
  • Medical University of South Carolina

    Medical University of South Carolina

    a month ago

    Registered nurse - pcu - nights

    Job Description Summary Under general supervision, the Registered Nurse provides individualized, goal-directed patient care to families and patients at a competent level utilizing the principles and...

    onsite, Columbia, SC, United States
    $60k/yrFull TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    a month ago

    Registered nurse- medtele prn-nights

    Job Description Summary Under general supervision, the Registered Nurse provides individualized, goal-directed patient care to families and patients at a competent level utilizing the principles and...

    onsite, Columbia, SC, United States
    $105k/yrPart TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    a month ago

    Registered nurse - cssu - prn

    Job Description Summary Under general supervision, the Registered Nurse II provides individualized, goal-directed patient care to families and patients at a competent level utilizing the principles...

    onsite, Columbia, SC, United States
    $105k/yrPart TimeJunior (<2 years)

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