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  2. South Carolina
  3. Columbia
  4. Nurse Practitioner

Onsite Nurse Practitioner jobs in Columbia, South Carolina, USA

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      Sarah Jenkins

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      Alex Chen

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      David G. (Hiring Manager)

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      Sophie L.

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      Marta W.

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      Daria (HR)

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      James Miller

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      Chris V.

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Nurse Practitioner Jobs in Columbia — On-Site Opportunities Await

Columbia, South Carolina's healthcare network is expanding, creating strong demand for skilled professionals ready to make an impact in patient care. We currently have 165 on-site nurse practitioner jobs in Columbia available, offering a chance to join a thriving clinical community. This growth reflects the region's commitment to quality healthcare and its need for dedicated practitioners.

Success in this role calls for strong clinical assessment skills, sound diagnostic judgment, and the ability to manage diverse patient needs with compassion and precision. Employers seeking to hire a nurse practitioner often prioritize candidates with excellent communication skills, a collaborative mindset, and up-to-date knowledge of evidence-based practices. Familiarity with electronic health records and a commitment to continuous learning further strengthen a candidate's profile in this competitive field.

On-site work in Columbia means direct, hands-on collaboration with physicians, specialists, and support staff within established healthcare facilities. The city's growing population and expanding medical infrastructure continue to drive nurse practitioner positions across hospitals, clinics, and private practices. The regional hiring outlook remains strong, with healthcare systems actively investing in both experienced and emerging talent.

If you're ready to advance your career and make a meaningful difference in patients' lives, explore current nurse practitioner vacancies through Global Work AI. Our platform connects dedicated professionals with employers eager to welcome new talent onto their teams. Take the next step toward a rewarding on-site career in Columbia today.

Frequently Asked
Questions

Everything you need to know about
finding your next role
  • What is the average salary for a nurse practitioner in Columbia?

    Pay for a nurse practitioner in Columbia, South Carolina typically falls in a competitive range shaped by specialty, years of experience, and employer type. In the Columbia area, hospital systems, primary care groups, and specialty clinics often post annual wages around the low-to-mid $100,000s, with higher totals possible when bonuses or shift differentials apply. Market rates can shift with demand and credentialing requirements, so it helps to compare current listings, benefit packages, and call expectations before judging an offer. Local cost of living and clinical setting also influence the final number.
  • What qualifications and certifications are required to become a nurse practitioner in South Carolina?

    Entry into this role usually starts with an accredited master’s or doctoral nursing degree, followed by national board certification in a population focus such as family, adult-gerontology, pediatrics, or psychiatric-mental health. In South Carolina, advanced practice authorization also depends on meeting state nursing board requirements, including RN licensure and prescribed education in pharmacology and advanced clinical practice. Employers in Columbia often look for DEA eligibility and experience relevant to the care setting. Reviewing current state rules and matching your background to the specialty can clarify whether you are ready to apply.
  • What clinical skills are most important for a nurse practitioner role?

    Strong diagnostic judgment matters most, along with a steady bedside manner and the ability to synthesize histories, exams, and test results quickly. For a nurse practitioner in an on-site Columbia setting, employers also value prescribing knowledge, chart accuracy, patient education, triage, and comfort with evidence-based protocols. Communication is essential because you may coordinate with physicians, nurses, pharmacists, and case managers throughout the day. The best candidates show clear reasoning, safe decision-making, and adaptability in fast-moving care environments, so it can be useful to compare these strengths with the skills listed in current openings.
  • What are the main responsibilities of a nurse practitioner in an on-site hospital or clinic setting?

    Daily duties usually include assessing patients, ordering and interpreting diagnostics, developing treatment plans, prescribing medications within scope, and following up on progress. In a Columbia hospital or clinic, a nurse practitioner may also manage chronic disease, perform minor procedures, document encounters in the EHR, and coordinate referrals with specialists. Depending on the department, the role can involve inpatient rounds, urgent visits, or routine primary care. Because on-site care is team-based, collaboration and timely communication are central to the job, and it helps to review how each employer structures supervision and workflow.
  • Is a current South Carolina nurse practitioner license required for this role?

    Yes, most employers in Columbia expect active authority to practice in South Carolina before a candidate starts. That usually means an unencumbered RN license plus the advanced practice credentials required by the state nursing board for a nurse practitioner. Some health systems may interview applicants who are near completion, but final onboarding generally depends on current state approval and any required prescriptive authority. If you are moving from another state, licensing timelines can affect start dates, so it is wise to check the board’s rules and confirm what each listing requires.
  • What does the hiring process look like for a nurse practitioner position in Columbia?

    The process often begins with an application review, followed by recruiter screening, one or more interviews, and verification of licenses, certification, and work history. In Columbia, employers may also request references, background checks, immunization records, drug screening, and credentialing documents before making an offer. Hospital and clinic systems can move at different speeds depending on specialty and staffing need. Candidates usually have the best experience when they prepare examples of clinical judgment, teamwork, and patient communication, then compare timelines and onboarding steps across similar nurse practitioner openings in the area.
  • What work schedule and on-site conditions should I expect in this nurse practitioner job?

    Schedules vary by unit, but an on-site nurse practitioner role in Columbia may involve weekday clinic hours, rotating shifts, weekend coverage, or occasional call depending on patient demand. Hospital-based jobs can bring earlier starts, faster pace, and exposure to higher-acuity cases, while outpatient settings may offer more predictable hours with a busy appointment flow. You should expect in-person collaboration, standing or walking for much of the day, and regular use of electronic records and clinical equipment. Reviewing shift patterns, patient volume, and support staff levels can help you judge fit before applying.

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165 jobs found

  • Life Care Center of Columbia SC

    Life Care Center of Columbia SC

    Today

    Registered nurse (rn) supervisor

    Position Summary The RN Supervisor is responsible for the coordination of the patient’s care and services. Promotes quality care using a collaborative process that coordinates, monitors, and...

    onsite, Columbia, SC, United States
    Part TimeLead / Manager
  • DaVita Kidney Care

    DaVita Kidney Care

    3 days ago

    Licensed practical nurse

    Posting Date 10/26/2026 5 Richland Medical Park Dr, Columbia, South Carolina, 29203-6863, United States of America DaVita is seeking a Licensed Practical Nurse who is looking to give life in a...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    3 days ago

    Registered nurse (rn)-acute care, family beginnings mother baby, ft, nights

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Veterans Health Administration

    Veterans Health Administration

    3 days ago

    Registered nurse - assistant nurse manager - emergency department

    Summary Fundamental knowledge of the unit and is responsible and accountable for all elements of the nursing process when providing or supervising direct patient care. Assesses, plans, implements,...

    onsite, Columbia, SC, United States
    $87k/yrFull TimeJunior (<2 years)
  • Veterans Health Administration

    Veterans Health Administration

    4 days ago

    Nurse practitioner - psychiatric mental health

    Summary This position is eligible for the Education Debt Reduction Program (EDRP), a student loan payment reimbursement program. You must meet specific eligibility requirements per VHA policy and...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Milan Laser Hair Removal

    Milan Laser Hair Removal

    4 days ago

    Nurse practitioner

    Location: Columbia (Forest Acres), SC Status: Full-Time Clinic Hours: Mon-Thur 8:30am-6pm, Fri-Sat 7:30am-5pm Delivering confidence through precision, empathy, and excellence As a Laser Hair Removal...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Armor Health

    Armor Health

    4 days ago

    Psychiatric nurse practitioner

    Overview At Armor Health we are raising the standard of care to impact the lives of those we serve by partnering with exceptional correctional organizations to improve health care outcomes. We...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Armor Health

    Armor Health

    4 days ago

    Nurse practitioner

    Overview Great outcomes start with great people and Armor has an exciting opportunity for a Nurse Practitioner to join our team. What's in it for YOU? Join an organization with excellent teamwork and...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • PruittHealth

    PruittHealth

    7 days ago

    Regional manager nurse practitioner

    Nurse Practitioner or Physician Assistant NP PA- PruittHealth Premier Services Long Term Care Health Plan - Must be licensed in SC Monday -Friday with Flexibility No Eve or Weekend onsite Required...

    onsite, Charleston, SC, United States
    Full TimeLead / Manager
  • AdamsPlace

    AdamsPlace

    7 days ago

    Lpn licensed practical nurse

    Position: Licensed Practical Nurse (LPN) Are you looking to make a difference in the lives of others by sharing your care and compassion? Do you enjoy connecting with your patients while getting to...

    onsite, Columbia, SC, United States
    Full TimeEntry with Degree
  • Medical University of South Carolina

    Medical University of South Carolina

    7 days ago

    Advanced practice provider | neonatal nurse practitioner (nnp)| musc health columbia medical center northeast - columbia, sc

    Job Description Summary The Medical University of South Carolina (MUSC) is seeking a highly skilled and confident Neonatal Nurse Practitioner (NNP) to join our established Level I/II neonatal...

    onsite, Columbia, SC, United States
    Full TimeSenior (5+ years)
  • BAYADA Home Health Care

    BAYADA Home Health Care

    9 days ago

    Registered nurse (rn)

    Fall Into Purpose-Driven Nursing with BAYADA Our Columbia Skilled Office is interested in a Registered Nurse (RN) who has a passion for home care to join our Skilled Private Duty Nursing team. We...

    onsite, Columbia, SC, United States
    $60k – $65k/yrPart TimeJunior (<2 years)
  • BAYADA Home Health Care

    BAYADA Home Health Care

    9 days ago

    Licensed practical nurse (lpn)

    Fall Into Purpose-Driven Nursing with BAYADA Our Columbia Skilled Office is interested in a Licensed Practical Nurse (LPN) who has a passion for home care to join our Skilled Private Duty Nursing...

    onsite, Columbia, SC, United States
    $52k – $56k/yrPart TimeJunior (<2 years)
  • BAYADA Home Health Care

    BAYADA Home Health Care

    10 days ago

    Lpn - home care nurse

    Fall Into Purpose-Driven Nursing with BAYADA Our Columbia Skilled Office is interested in a Licensed Practical Nurse (LPN) who has a passion for home care to join our Skilled Private Duty Nursing...

    onsite, Columbia, SC, United States
    $52k – $56k/yrPart TimeJunior (<2 years)
  • BAYADA Home Health Care

    BAYADA Home Health Care

    10 days ago

    Private duty nurse (lpn)

    Fall Into Purpose-Driven Nursing with BAYADA Our Columbia Skilled Office is interested in a Licensed Practical Nurse (LPN) who has a passion for home care to join our Skilled Private Duty Nursing...

    onsite, Columbia, SC, United States
    $52k – $56k/yrPart TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    10 days ago

    Registered nurse (rn) - acute care, surgical trauma, ft, days

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Urgent Care Management or Joint Venture Partner

    Urgent Care Management or Joint Venture Partner

    12 days ago

    Urgent care nurse practitioner or physician assistant- columbia, sc

    Up to $5,000 Sign-On Bonus! Limited-time opportunity available to the eligible hires. Prisma Health Urgent Care seeks talented, patient-oriented Physician Assistants and Nurse Practitioners who are...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Urgent Care Management or Joint Venture Partner

    Urgent Care Management or Joint Venture Partner

    12 days ago

    Urgent care nurse practitioner or physician assistant- garners ferry, sc

    Prisma Health Urgent Care seeks talented, patient-oriented Physician Assistants and Nurse Practitioners who are relentlessly dedicated to ensure the delivery of exceptional customer service by...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Urgent Care Management or Joint Venture Partner

    Urgent Care Management or Joint Venture Partner

    12 days ago

    Urgent care nurse practitioner or physician assistant- columbia, sc (float)

    Up to $5,000 Sign-On Bonus! Limited-time opportunity available to the eligible hires. Prisma Health Urgent Care seeks talented, patient-oriented Physician Assistants and Nurse Practitioners who are...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    12 days ago

    Registered nurse (rn)-ambulatory, psychiatry, ft, day

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides and coordinates nursing care in a non-acute ambulatory, medical office, or urgent care setting in accordance with the...

    onsite, Columbia, SC, United States
    Full TimeEntry with Degree
  • Veterans Health Administration

    Veterans Health Administration

    13 days ago

    Inpatient staff registered nurse

    Summary The Inpatient Staff Registered Nurse (RN) executes position responsibilities that demonstrate leadership, experience, and creative approaches to management of complex patient care. Duties...

    onsite, Columbia, SC, United States
    $80k/yrFull TimeJunior (<2 years)
  • Prisma Health Urgent Care

    Prisma Health Urgent Care

    13 days ago

    Urgent care nurse practitioner or physician assistant- columbia, sc (float)

    Up to $5,000 Sign-On Bonus! Limited-time opportunity available to the eligible hires. Prisma Health Urgent Care seeks talented, patient-oriented Physician Assistants and Nurse Practitioners who are...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    14 days ago

    Assistant nurse manager (anm) operating room, ft, days

    Inspire health. Serve with compassion. Be the difference. Job Summary In collaboration with the nurse manager, supervises staff and unit operations and provides direct patient care. Supervises care...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    14 days ago

    Registered nurse (rn)-clinical nurse educator i, ft, days

    Inspire health. Serve with compassion. Be the difference. Job Summary Responsible for preparing the healthcare workforce for the clinical setting by teaching competency-based curriculum programs....

    onsite, Columbia, SC, United States
    Full TimeMiddle (2-4 years)
  • Prisma Health

    Prisma Health

    15 days ago

    Nurse practitioner / physician assistant - urology - columbia

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides primary health care to a specific patient population within the guidelines of written protocols. Follows established...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    15 days ago

    Registered nurse -prn ne

    Job Description Summary Under general supervision, the Registered Nurse II provides individualized, goal-directed patient care to families and patients at a competent level utilizing the principles...

    onsite, Columbia, SC, United States
    $105k/yrPart TimeJunior (<2 years)
  • PruittHealth

    PruittHealth

    16 days ago

    Registered nurse-prn

    REGISTERED NURSE-PRN Join the PruittHealth family, where the health and safety of our workforce is our top priority! We're not only committed to your career, we're committed to the health and safety...

    onsite, Columbia, SC, United States
    Part TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    16 days ago

    Registered nurse (rn) - ambulatory, internal resource pool, ft, days

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an ambulatory setting under the direction of the physician,...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    17 days ago

    Registered nurse (rn)-acute care, icu intermediate, ft, varied shifts

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Angels of Care Pediatric Home Health

    Angels of Care Pediatric Home Health

    19 days ago

    Licensed practical nurse (lpn) / registered nurse (rn) – pediatric home health

    Licensed Practical Nurse (LPN) / Registered Nurse (RN) – Private Duty Pediatric Nurse Columbia, SC | Surrounding Areas Pay Range: $29+/hour Make a Difference One Patient at a Time Angels of Care...

    onsite, Columbia, SC, United States
    $58k/yrPart TimeJunior (<2 years)
  • Cherokee Federal

    Cherokee Federal

    20 days ago

    Nurse practitioner, aprn, fnp

    A government contract requires that this position be restricted to U.S. citizens. This position requires a Common Access Card (CAC), and the ability to pass the U.S. Department of Defense (DoD)...

    onsite, Charlotte, NC, United States
    $120k – $130k/yrFull TimeJunior (<2 years)
  • Prisma Health Urgent Care

    Prisma Health Urgent Care

    22 days ago

    Urgent care nurse practitioner or physician assistant- garners ferry, sc

    Prisma Health Urgent Care seeks talented, patient-oriented Physician Assistants and Nurse Practitioners who are relentlessly dedicated to ensure the delivery of exceptional customer service by...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Fast Pace Health

    Fast Pace Health

    23 days ago

    Nurse (lpn or rn)

    Overview At Fast Pace Urgent Care, Nurses provide clinical and administrative support essential for effective patient care under the direct supervision of a Provider, Nurse Practitioner or Physician...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Angels of Care Pediatric Home Health

    Angels of Care Pediatric Home Health

    a month ago

    Licensed practical nurse (lpn) – private duty pediatric nurse

    Licensed Practical Nurse (LPN) – Private Duty Pediatric Nurse Columbia, SC | Surrounding Areas Pay Range: $29+/hour Make a Difference One Patient at a Time Angels of Care Pediatric Home Health is...

    onsite, Columbia, SC, United States
    $58k/yrPart TimeJunior (<2 years)
  • WellStreet Urgent Care

    WellStreet Urgent Care

    a month ago

    Urgent care nurse practitioner or physician assistant- columbia, sc

    Prisma Health Urgent Care seeks talented, patient-oriented Physician Assistants and Nurse Practitioners who are relentlessly dedicated to ensure the delivery of exceptional customer service by...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    a month ago

    Registered nurse (rn)-ambulatory, cardiac rehab, ft

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides routine, standardized nursing care for patients under the supervision of the physician. Bonus This position is bonus...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    a month ago

    Registered nurse (rn) - nurse resident, winter 2027, surgical specialty

    Inspire health. Serve with compassion. Be the difference. Job Summary Responsible for attending all quality and core curriculum classes, actively participating in professional development workshops...

    onsite, Columbia, SC, United States
    Full TimeEntry with Degree
  • PruittHealth

    PruittHealth

    a month ago

    Licensed practical nurse - prn

    LICENSED PRACTICAL NURSE- PRN Part time available 7p-7a Join the PruittHealth family, where the health and safety of our workforce is our top priority! We're not only committed to your career, we're...

    onsite, Columbia, SC, United States
    Part TimeEntry with Degree
  • Prisma Health

    Prisma Health

    a month ago

    Nurse practitioner / physician assistant - allergy - columbia

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides assistant surgical services in the operating room as well as other selected medical services under the direction of the...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Lexington Medical Center

    Lexington Medical Center

    a month ago

    Office nurse practitioner

    Job Summary Assesses the physical and psychosocial status of patients by means of interview, health history, physical examination and diagnostic tests. Interprets the data, develops and implements a...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)

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