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  2. Iowa
  3. Des Moines
  4. Nurse Practitioner

Onsite Nurse Practitioner jobs in Des Moines, Iowa, USA

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  • Sun
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      Sarah Jenkins

    • 2:30 PM - 3:00 PM

      Initial Interview

      Alex Chen

  • Mon
    • 11:00 AM - 11:15 AM

      Product Manager Interview

      David G. (Hiring Manager)

    • 4:15 PM - 5:15 PM

      First Round Interview

      Sophie L.

  • Tue
    • 1:20 PM - 1:45 PM

      Introductory Interview

      Marta W.

    • 2:30 PM - 3:00 PM

      Kick-off Interview

      Daria (HR)

  • Wed
    • 1:00 PM - 1:45 PM

      Qualifying Interview

      James Miller

    • 5:30 PM - 6:00 PM

      Discovery Interview

      Chris V.

  • Thu
    • 2:30 PM - 3:00 PM

      First Interview

      Michael T.

    • 4:00 PM - 5:00 PM

      Interview

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Nurse Practitioner On-Site Jobs: Discover Opportunities in Des Moines

Healthcare providers across Des Moines are actively seeking skilled nurse practitioner jobs in Des Moines to meet growing patient demand. This on-site role offers 111 open positions for professionals ready to make a direct impact within local clinics and hospitals. As Iowa's healthcare sector expands, qualified candidates have strong opportunities to join dynamic medical teams.

Successful nurse practitioner vacancies call for strong clinical judgment, patient assessment skills, and the ability to collaborate with physicians and support staff. Employers value candidates who demonstrate excellent communication, adaptability, and a commitment to evidence-based care. Familiarity with electronic health records and chronic disease management further strengthens a candidate's profile in this competitive field.

On-site nurse practitioner positions in Des Moines typically involve hands-on patient care within hospitals, clinics, and specialty practices. The region's steady population growth and expanding healthcare infrastructure continue to drive a strong hiring outlook, making it an ideal time for professionals to establish or advance their careers locally.

If you're ready to take the next step, Global Work AI invites you to explore current openings for employers looking to hire a nurse practitioner. Discover a role that matches your expertise and passion for patient care, and start building a rewarding career today.

Frequently Asked
Questions

Everything you need to know about
finding your next role
  • What is the average nurse practitioner salary in Des Moines?

    Compensation for a nurse practitioner in Des Moines is generally competitive with other Midwestern markets, though exact pay varies by specialty, years of experience, and employer type. In Iowa, many NP roles fall roughly in the low-to-mid six-figure range, with higher offers more common in acute care, specialty clinics, and settings that require advanced procedures or rotating coverage. Benefits, call expectations, and bonuses can also affect total value. Review current Des Moines listings to compare base pay with the full package and local cost of living.
  • What qualifications and certifications are required for a nurse practitioner job in Iowa?

    Most employers in Iowa expect an active registered nurse license, a graduate degree in nursing practice, and national board certification in the chosen population focus, such as family, adult-gerontology, pediatric, or psychiatric care. An Iowa APRN license is also required, along with prescriptive authority if the role includes medication management. Some positions may ask for BLS or ACLS, depending on the setting. Because rules can vary by specialty and facility, it helps to review the current Iowa Board of Nursing requirements before applying.
  • What responsibilities are typically included in an on-site nurse practitioner role?

    An on-site nurse practitioner usually provides direct patient care, performs exams, orders and interprets tests, diagnoses conditions, and develops treatment plans under facility protocols and state practice rules. In Des Moines clinics or hospitals, the role may also include medication management, patient education, documentation in the EHR, and coordination with physicians, nurses, and specialists. Depending on the department, tasks can range from urgent visits to chronic disease follow-up. Checking role-specific listings can help you see which duties are tied to each employer.
  • What does a typical day look like for a nurse practitioner in a clinic or hospital setting?

    A standard shift often starts with chart review, schedule planning, and brief team huddles, followed by patient visits, assessments, and care decisions throughout the day. In a clinic, a nurse practitioner may see scheduled appointments, handle follow-ups, and manage ongoing conditions. In a hospital, the pace can shift toward admissions, rounds, consults, and urgent needs. Documentation, care coordination, and communication with families or other clinicians take up a meaningful share of the day. Comparing clinic and hospital openings in Iowa can clarify the rhythm you prefer.
  • What clinical skills and experience do employers look for in a nurse practitioner?

    Hiring teams in Des Moines usually look for strong assessment skills, sound clinical judgment, and confidence with evidence-based decision-making. Experience in primary care, urgent care, family medicine, or a relevant specialty can be especially valuable, along with familiarity with EHR systems, patient education, and preventive care. Employers also value clear communication, teamwork, and the ability to handle a steady patient load while staying accurate and organized. Recent hands-on clinical training, preceptorship experience, and exposure to Iowa practice settings can make an application stand out.
  • What is the hiring process for nurse practitioner jobs in Des Moines?

    The process typically begins with an application and screening of credentials, followed by one or more interviews with clinical leaders or HR staff. Many Des Moines employers will verify licensure, national certification, education, references, and prior experience, and some may ask about scope of practice, patient volume, or specialty knowledge. Depending on the organization, you may also complete a background check, drug screen, and onboarding paperwork before a start date is set. Reviewing several local openings can help you prepare for common interview themes.
  • What career growth opportunities are available for nurse practitioners in Iowa?

    Career paths in Iowa can expand into specialty practice, leadership, education, quality improvement, telehealth support, or advanced inpatient services. A nurse practitioner in Des Moines may move into roles with greater autonomy, supervisory duties, or a focused patient population such as cardiology, oncology, or behavioral health. Additional certifications and continuing education can strengthen advancement prospects, especially in health systems with structured ladders. Because demand can shift by region and specialty, it’s useful to compare openings across Iowa and look for employers that support long-term development.

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111 jobs found

  • UnityPoint Health

    UnityPoint Health

    5 days ago

    Registered nurse residency (new grad)

    Overview Registered Nurse Residency- General Application Shift: Varied per department - Full Time Now Offering a Limited-Time $20,000 RN Sign-On Bonus! UnityPoint Health – Des Moines is offering a...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • Trinity Health

    Trinity Health

    5 days ago

    Clinic registered nurse (rn): primary care

    Employment Type: Full time Shift: Day Shift Description: At MercyOne, health care is more than just a doctor’s visit or a place to go when you’re in need of medical attention. Our Mission is based on...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • Fresenius Medical Care

    Fresenius Medical Care

    5 days ago

    Outpatient registered nurse - rn

    Outpatient Registered Nurse - RN SIGN ON BONUS AVAILABLE! PURPOSE AND SCOPE: The professional registered nurse Outpatient RN CAP 1 is an entry level designation into the Clinical Advancement Program...

    onsite, Des Moines, IA, United States
    Full TimeLead / Manager
  • Compassus

    Compassus

    6 days ago

    Hospice registered nurse- prn rn

    Company: Compassus Position Summary The Hospice Registered Nurse is responsible for modeling the Compassus values of Compassion, Integrity, Excellence, Teamwork, and Innovation and for promoting the...

    onsite, Des Moines, IA, United States
    Part TimeEntry with Degree
  • UnityPoint Health

    UnityPoint Health

    6 days ago

    Nurse manager- north 6 general surgery- methodist

    Overview The nurse manager has 24 hour accountability and responsibility for a direct care unit or units. The manager is responsible for creating safe, healthy environments that support the work of...

    onsite, Des Moines, IA, United States
    Full TimeMiddle (2-4 years)
  • Compassus

    Compassus

    7 days ago

    Nurse practitioner - ppv/prn

    Company: Compassus Position Summary The Nurse Practitioner - PPV is responsible for modeling the Compassus values of Compassion, Integrity, Excellence, Teamwork, and Innovation and for promoting the...

    onsite, Des Moines, IA, United States
    Part TimeLead / Manager
  • UnityPoint Health

    UnityPoint Health

    7 days ago

    Clinic nurse- blank pediatric endocrinology clinic

    Overview Full-Time or Part-Time Days Monday-Friday 7:30am-4pm If you’re a Registered Nurse looking to make a meaningful impact beyond the bedside, UnityPoint Health – Blank Children’s Endocrinology...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • UnityPoint Health

    UnityPoint Health

    7 days ago

    Registered nurse residency- younker 7 med/surg- methodist

    Overview Full Time Days or Nights, every 3rd weekend and holiday rotation Now Offering a Limited-Time $20,000 RN Sign-On Bonus! UnityPoint Health – Des Moines is offering a $20,000 sign-on bonus for...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • UnityPoint Health

    UnityPoint Health

    8 days ago

    Licensed practical nurse - lpn - methodist internal medicine clinic - $5,000 sign-on bonus offered!

    Overview UnityPoint Clinic LPN - Licensed Practical Nurse Methodist Internal Medicine Clinic Des Moines, IA Monday-Friday 8AM-5PM - half day TBD Full-time + benefits $5,000 sign-on bonus offered!...

    onsite, Des Moines, IA, United States
    $5k/yrFull TimeJunior (<2 years)
  • Fresenius Medical Care

    Fresenius Medical Care

    8 days ago

    New graduate registered nurse - rn

    PURPOSE AND SCOPE: This position is for graduates of an accredited school of Nursing working in a state that does not allow graduates to perform nursing duties until licensed. The specific job title...

    onsite, Algona, IA, United States
    Full TimeEntry with Degree
  • Naphcare, Inc.

    Naphcare, Inc.

    8 days ago

    Nurse practitioner

    Overview NaphCare is hiring a Nurses Practitioner to join our team of medical professionals in Des Moines, Iowa, where we manage all aspects of healthcare for the individuals who are currently...

    onsite, Des Moines, IA, United States
    Part TimeJunior (<2 years)
  • Cassia

    Cassia

    9 days ago

    Licensed practical nurse lpn 5000 bonus

    Valley View Village, a Cassia community, is hiring Licensed Practical Nurses (LPN) to join our team! Staff enjoy a favorable staff-to-resident ratio which allows us to provide exceptional care and...

    onsite, Des Moines, IA, United States
    $60k – $73k/yrFull TimeJunior (<2 years)
  • Veterans Health Administration

    Veterans Health Administration

    12 days ago

    Registered nurse- diabetes educator

    Summary The Diabetes Educator is a Registered Nurse (RN) responsible for providing competent, evidence-based diabetes education to staff and patients throughout the medical facility. The Diabetes...

    onsite, Des Moines, IA, United States
    $75k/yrFull TimeEntry with Degree
  • UnityPoint Health

    UnityPoint Health

    12 days ago

    Specialty nurse - methodist ob/gyn

    Overview UnityPoint Health CMA/LPN/RN OB/GYN Clinic - Des Moines Des Moines, IA Monday-Friday 4 days/week - 7:45AM-5:15PM Full-time + benefits We are seeking a dedicated and compassionate Specialty...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • Veterans Health Administration

    Veterans Health Administration

    12 days ago

    Advanced nurse practitioner - pulmonary

    Summary The Central Iowa VA Healthcare Facility in Des Moines, IA is recruiting for (1) Full-Time APN - Pulmonary. Duties The VA Midwest Health Care Network advocates for a Whole Health System of...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • DaVita Kidney Care

    DaVita Kidney Care

    12 days ago

    Registered nurse

    Posting Date 10/16/2026 1201 Pennsylvania Ave, Des Moines, Iowa, 50316-2339, United States of America $10,000 BONUS LOCATED IN DES MOINES NO SUNDAY WORK NO NIGHTS DaVita is seeking a Registered Nurse...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • Select Specialty Hospital - Des Moines

    Select Specialty Hospital - Des Moines

    13 days ago

    Registered nurse (rn) - full-time new graduate

    Overview Position: New Graduate Registered Nurse (RN) Location: Des Moines, IA Schedule: Full-Time - New Graduate- Day & Night Available Sign-on bonus: $15,000 Select Specialty Hospital is a critical...

    onsite, Des Moines, IA, United States
    $15k/yrFull TimeEntry with Degree
  • Iowa Ortho

    Iowa Ortho

    13 days ago

    Prn rounding nurse

    The rounding nurse provides physical and educational support for the physician while rounding on postoperative and non-operative orthopedic patients that are inpatient. The rounding nurse assists...

    onsite, Des Moines, IA, United States
    Part TimeJunior (<2 years)
  • Trinity Health

    Trinity Health

    14 days ago

    Pcu rn – progressive care registered nurse

    Employment Type: Full time Shift: 12 Hour Night Shift Description: RN Progressive Care Unit Nights New RN Rate Employment Type: Full Time - 36 hours per week Shift Schedule: Night Shift (7 PM - 7 AM)...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • Naphcare, Inc.

    Naphcare, Inc.

    15 days ago

    Registered nurse (rn)

    Overview NaphCare is hiring Registered Nurses (RNs) to join our team of medical professionals in Des Moines, Iowa where we manage all aspects of healthcare for the individuals who are currently...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • Select Specialty Hospital - Des Moines

    Select Specialty Hospital - Des Moines

    15 days ago

    Registered nurse (rn) - per diem

    Overview Position: Registered Nurse (RN) Location: Des Moines, IA Schedule: PRN / As Needed, Day & Night Shift, 12-Hour Shifts Compensation: $47.00 per hour plus competitive shift differentials for...

    onsite, Des Moines, IA, United States
    $95k/yrPart TimeJunior (<2 years)
  • Ascension Recovery Services

    Ascension Recovery Services

    15 days ago

    Nurse practitioner outpatient

    Nurse Practitioner – Outpatient Behavioral Health & Addiction Medicine Thrive Now Recovery Centers (Outpatient) Des Moines, Iowa Full-Time | Outpatient Anticipated Opening: Late 2026 Join Thrive Now...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • UnityPoint Health

    UnityPoint Health

    16 days ago

    Registered nurse residency- medical/respiratory- methodist

    Overview Full Time Nights 7pm-7:30am, every 3rd weekend and holiday rotation Now Offering a Limited-Time $20,000 RN Sign-On Bonus! UnityPoint Health – Des Moines is offering a $20,000 sign-on bonus...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • UnityPoint Health

    UnityPoint Health

    16 days ago

    Registered nurse residency-3e med/surg-lutheran

    Overview Nurse Residency - 3 East Medical/Surgical - Lutheran Shifts: Full-time Nights, every 3rd weekend and holiday rotation Benefits Eligible Shift Differential for qualifying shifts Full Time...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • UnityPoint Health

    UnityPoint Health

    16 days ago

    Specialty nurse-infectious disease-methodist

    Overview UnityPoint Health LPN or Registered Nurse (RN) – Specialty Clinic: Infectious Disease Methodist Downtown Des Moines Monday to Friday, 8:00 am to 5:00 pm Full-time + benefits Willing to train...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • UnityPoint Health

    UnityPoint Health

    19 days ago

    Specialty nurse - rn - methodist cardiology

    Overview UnityPoint Health Registered Nurse (RN) Specialty Clinic Cardiology Methodist Downtown Des Moines Monday to Friday 8AM-4:30PM Full-time + benefits We are seeking a compassionate and...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • UnityPoint Health

    UnityPoint Health

    19 days ago

    Specialty nurse- cardiology ep- methodist

    Overview UnityPoint Health Registered Nurse (RN) Specialty Clinic EP Cardiology Methodist Downtown Des Moines Monday to Friday, 8:00am to 5:00 pm Full-time + benefits We are seeking a compassionate...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • UnityPoint Health

    UnityPoint Health

    19 days ago

    Neonatology - nurse practitioner - blank children's hospital - des moines, ia

    Overview Blank Children’s Hospital is actively recruiting for a part-time Neonatology Nurse Practitioner to join our team in Des Moines, IA. Choose a career that matters at UnityPoint Health. At...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • Iowa Ortho

    Iowa Ortho

    20 days ago

    Operating room-registered nurse (rn)

    The Iowa Orthopedic Center, Surgery Center, a center of excellence, is currently searching for a skilled surgical RN who wants to work in a supportive, drama free environment and be a part of an...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • Trinity Health

    Trinity Health

    20 days ago

    Clinic registered nurse (rn): pulmonary & critical care

    Employment Type: Full time Shift: Day Shift Description: At MercyOne, health care is more than just a doctor’s visit or a place to go when you’re in need of medical attention. Our Mission is based on...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • Trinity Health

    Trinity Health

    20 days ago

    Clinic registered nurse (rn): palliative care

    Employment Type: Full time Shift: Day Shift Description: At MercyOne, health care is more than just a doctor’s visit or a place to go when you’re in need of medical attention. Our Mission is based on...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • Trinity Health

    Trinity Health

    a month ago

    Main or nurse clinician

    Employment Type: Full time Shift: Day Shift Description: GENERAL SUMMARY: Provides perioperative patient care, specifically in the intraoperative phase, in both the scrub and circulating roles...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • Veterans Health Administration

    Veterans Health Administration

    a month ago

    Registered nurse- medical surgical nurse manager

    Summary This position is eligible for the Education Debt Reduction Program (EDRP), a student loan payment reimbursement program. You must meet specific eligibility requirements per VHA policy and...

    onsite, Des Moines, IA, United States
    $80k/yrFull TimeMiddle (2-4 years)
  • Fresenius Medical Care

    Fresenius Medical Care

    a month ago

    Acute inpatient registered nurse - rn

    PURPOSE AND SCOPE: The professional registered nurse Inpatient Services RN CAP 1 is an entry level designation into the Clinical Advancement Program (CAP). This position is accountable and...

    onsite, Des Moines, IA, United States
    Full TimeLead / Manager
  • Concentra

    Concentra

    a month ago

    Registered nurse � full time

    Overview Schedule: Monday - Friday 6:30AM - 3:30PM! (Includes 1-hour lunch break) Are you ready to take your career to new heights? At Concentra, you will be a vital member of our patient care team...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • UnityPoint Health

    UnityPoint Health

    a month ago

    Nurse supervisor- adult rehab- methodist

    Overview Shift: 40 hours/week Leadership Role | Iowa Methodist Medical Center $20,000.00 New Hire Sign On Bonus for external hires! Younker Rehabilitation has been providing rehabilitation services...

    onsite, Des Moines, IA, United States
    $20k/yrFull TimeMiddle (2-4 years)
  • WesleyLife

    WesleyLife

    a month ago

    Registered nurse/licensed practical nurse (rn/lpn)

    Join WesleyLife and Help Revolutionize the Aging Experience! Job Duties: Registered Nurse or Licensed Practical Nurse Provide direct nursing care, such as wound care, IV therapy, and catheter...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • ChildServe

    ChildServe

    a month ago

    Nurse evening team lead (full-time)

    The Clinical Team Lead directly responsible for ensuring the clinical needs of each child are implemented by supporting a multidisciplinary team approach to clinical care. The Clinical team Lead is...

    onsite, Des Moines, IA, United States
    Full TimeLead / Manager
  • Trinity Health

    Trinity Health

    a month ago

    Clinic registered nurse (rn): neurology

    Employment Type: Full time Shift: Day Shift Description: At MercyOne, health care is more than just a doctor’s visit or a place to go when you’re in need of medical attention. Our Mission is based on...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • UnityPoint Health

    UnityPoint Health

    a month ago

    Clinic nurse- blank pediatrics clinic

    Overview Full-Time Days 32 hrs/week - 4 days per week 8am-5:pm with rotating Saturdays 8am-2pm At Blank Children’s General Pediatrics Clinic, nursing is more than a job—it’s a chance to make a...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)

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