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  2. South Carolina
  3. Travel Nurse

Onsite Travel Nurse jobs in South Carolina, USA

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Travel Nurse Jobs in South Carolina — On-Site Opportunities Await Dedicated Caregivers

South Carolina's hospitals and healthcare systems are actively seeking skilled professionals to fill 500+ travel nurse on-site jobs across the state. As patient volumes rise and staffing shortages persist, facilities from coastal cities to inland communities need adaptable nurses who can step in quickly. This growing demand makes now an excellent time to explore travel nurse vacancies.

Successful candidates bring strong clinical judgment, adaptability, and the ability to integrate into new teams within days of arrival. Proficiency in electronic health records, sharp communication skills, and current state licensure or compact eligibility are essential for most travel nurse positions. Employers also value nurses who demonstrate resilience under pressure, cultural competence, and genuine passion for patient-centered care.

On-site work remains the standard for this profession, since direct patient contact and hands-on care cannot be replicated remotely. Hospitals across South Carolina, from bustling urban medical centers to rural critical access facilities, continue to hire a travel nurse whenever local staff shortages emerge. The state's expanding healthcare infrastructure and seasonal population shifts keep demand steady, creating consistent opportunities for nurses willing to relocate temporarily for rewarding assignments.

If you're ready to bring your expertise to South Carolina's healthcare community, now is the moment to pursue a new assignment. Global Work AI connects motivated nurses with facilities eager to welcome fresh talent, making it simple to discover travel nurse jobs that match your goals and schedule. Take the next step in your career and find the opportunity that fits you best.

Frequently Asked
Questions

Everything you need to know about
finding your next role
  • What is the average travel nurse salary in South Carolina?

    In South Carolina, a travel nurse often earns more than a staff RN because pay packages include taxable wages plus stipends for housing, meals, and incidentals. Typical annualized compensation can land around the low to mid-$90,000 range, though total earnings vary by specialty, facility, and shift demand. Hospitals in Charleston, Columbia, and Greenville may offer different rates depending on need and season. Because contract pay changes quickly, it helps to review current South Carolina listings and compare package details, not just the hourly figure.
  • How much do travel nurses make per week on assignment?

    Weekly pay for a travel nurse in South Carolina commonly falls in the $1,800 to $2,800 range, with some high-demand specialties reaching higher totals. The exact amount depends on guaranteed hours, overtime policy, tax-free stipends, and whether the contract is in a metro hospital or a smaller regional facility. In on-site roles, the housing arrangement can also affect take-home value. Since weekly pay can shift with census and specialty demand, it is smart to check active assignments and review the full compensation breakdown.
  • What qualifications do you need to become a travel nurse in the USA?

    To work as a travel nurse in the USA, most employers expect an accredited nursing degree, current RN licensure, and at least one to two years of recent bedside experience in a relevant unit. Certifications such as BLS, ACLS, or specialty credentials may be required for critical care, ER, or OR placements. Strong adaptability matters too, since assignments can change by hospital and region. Before applying, it helps to compare role requirements with your clinical background and identify gaps that may need updating.
  • Is an active RN license required for travel nurse jobs in South Carolina?

    Yes, an active RN license is generally required for travel nurse jobs in South Carolina. Most employers will accept a South Carolina RN license or a compact license if your home state is part of the Nurse Licensure Compact, which South Carolina participates in. Some agencies may also ask for verification of standing, immunization records, and recent skills documentation before onboarding. Because licensing rules can affect start dates, it is wise to confirm current state requirements and review listings that match your license status.
  • What does a travel nurse do during a typical shift on assignment?

    A shift usually looks much like a permanent staff role, but with added flexibility and quicker adaptation to local systems. In South Carolina hospitals and clinics, a travel nurse may assess patients, give medications, update charts, coordinate with physicians, and respond to changing unit priorities. You may also need to learn facility protocols, electronic records, and supply locations fast. The day can be busy, especially in high-acuity settings, so reviewing unit expectations and typical patient loads can help before accepting an assignment.
  • How does the hiring process work for travel nurse jobs in South Carolina?

    The hiring process usually starts with submitting your resume, license details, certifications, and work history to an agency or employer. After that, recruiters often match your skills with available South Carolina contracts, then arrange an interview with the facility if needed. Once selected, you complete compliance steps such as background checks, drug screening, health records, and references before your start date. Since timelines can move quickly in travel nursing, it is helpful to compare several openings and keep documents ready for review.
  • How long are travel nurse assignments, and can they be extended?

    Most travel nurse contracts run about 13 weeks, though some South Carolina placements may be shorter or longer depending on staffing needs. Extensions are common when a unit still has open shifts and your performance fits the team’s expectations. A facility may also renew a contract if patient volume stays high or a replacement is not available yet. Because extensions depend on both hospital demand and your availability, it is useful to track assignment end dates and ask about renewal terms early.

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500+ jobs found

  • Prisma Health

    Prisma Health

    a day ago

    Registered nurse (rn)- ambulatory, heritage pediatrics and internal medicine, ft, day

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides and coordinates nursing care in a non-acute ambulatory, medical office, or urgent care setting in accordance with the...

    onsite, Wren Creek, SC, United States
    Full TimeEntry with Degree
  • Prisma Health

    Prisma Health

    2 days ago

    Registered nurse (rn) - acute care, nicu, full time, night

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Seneca, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    2 days ago

    Registered nurse (rn) - acute care, family beginnings (postpartum), prn, nights

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Greenville, SC, United States
    Part TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    2 days ago

    Registered nurse (rn) -acute care, transplant and intermediate care unit, ft, day

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Greenville, SC, United States
    Full TimeJunior (<2 years)
  • Anders Group

    Anders Group

    3 days ago

    Travel registered nurse cath lab tech - $2263/week

    Anders Group is hiring a Travel Cath Lab Tech Registered Nurse (RN) in CHARLESTON, SC Location: CHARLESTON, SC Start Date: 10/23/2026 Contract Length: 13 Weeks Shift: 3x12 Nights Practice Area:...

    onsite, Charleston, SC, United States
    $109k/yrFull TimeJunior (<2 years)
  • Anders Group

    Anders Group

    3 days ago

    Travel registered nurse cath lab tech - $2516/week

    Anders Group is hiring a Travel Cath Lab Tech Registered Nurse (RN) in CHARLESTON, SC Location: CHARLESTON, SC Start Date: 11/16/2026 Contract Length: 13 Weeks Shift: 5x8 Days Practice Area: Hospital...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • LanceSoft

    LanceSoft

    4 days ago

    Hiring for family nurse practitioner in travelers rest, sc 29690

    Job ID: 26-146575 Job title: Nurse Practitioner - MC Position type: Fulltime/ part-time contract Location: Travelers Rest, SC 29690 Work type: Onsite Est. pay range: $70.00/ hour - $74.87/ hour on W2...

    onsite, Travelers Rest, SC, United States
    $141k – $151k/yrFull TimeJunior (<2 years)
  • Hoar

    Hoar

    4 days ago

    Traveling assistant safety manager

    The Assistant Safety Manager is responsible for overseeing the administration of the company Health and Safety Program (HSP) and contractual safety requirements to prevent and correct unsafe working...

    onsite, Charleston, SC, United States
    Full TimeMiddle (2-4 years)
  • Prisma Health

    Prisma Health

    5 days ago

    Registered nurse (rn) - navigator ambulatory, general surgery, ft, day

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides direct patient care, education and support to patients in a physician specialty practice with the objective of...

    onsite, Greenville, SC, United States
    Full TimeMiddle (2-4 years)
  • Prisma Health

    Prisma Health

    5 days ago

    Nurse manager (rn) - ambulatory nursing, direct primary care, ft

    Inspire health. Serve with compassion. Be the difference. Job Summary Directs and supervises clinical functions and activities of the department or group of practices; Implements and interprets...

    onsite, Greenville, SC, United States
    Full TimeMiddle (2-4 years)
  • Prisma Health

    Prisma Health

    5 days ago

    Registered nurse (rn) acute care, cardiac telemetry, ft, nights

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Laurens, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    6 days ago

    Registered nurse (rn)-acute care, facility resource pool - med/surg/tele, ft, night

    Inspire health. Serve with compassion. Be the difference. Job Summary Working for the Facility Resource Pool, provides clinical direction for all aspects of patient care in an acute inpatient...

    onsite, Greenville, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    6 days ago

    Registered nurse (rn)-acute care, emergency department, ft, various

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Greenville, SC, United States
    Full TimeJunior (<2 years)
  • Anders Group

    Anders Group

    6 days ago

    Travel registered nurse cath lab tech - $2517/week

    Anders Group is hiring a Travel Cath Lab Tech Registered Nurse (RN) in Columbia, SC Location: Columbia, SC Start Date: 11/09/2026 Contract Length: 13 Weeks Shift: 4x10 Days Practice Area: Hospital...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Comprehensive Mobile Care

    Comprehensive Mobile Care

    8 days ago

    Traveling part-time dentist | outpatient clinic setting | serving seniors

    About The Opportunity Comprehensive Mobile Care (CMC) is seeking a Traveling Part-Time Dentist to provide care in a structured, outpatient clinic-based environment in Central Michigan. This is a...

    onsite, Bay City, MI, United States
    Part TimeEntry with Degree
  • Prisma Health

    Prisma Health

    8 days ago

    Registered nurse (rn)-acute care, short stay surgical, ft, day

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Greenville, SC, United States
    Full TimeJunior (<2 years)
  • AnMed

    AnMed

    11 days ago

    Staff nurse - physician practice

    Located in the heart of Anderson, South Carolina, AnMed is a dynamic, not-for-profit health system dedicated to delivering exceptional care with compassion, innovation, and integrity. At AnMed, our...

    onsite, Anderson, SC, United States
    Full TimeEntry with Degree
  • Tenet Healthcare Corporation

    Tenet Healthcare Corporation

    11 days ago

    Rn pcu/ imcu travel and local contract rock hill sc

    This role provides direct clinical patient care. The role will assume responsibility for assessing, planning, implementing direct clinical care to assigned patients on a per shift basis, and unit...

    onsite, Rock Hill, SC, United States
    Part TimeJunior (<2 years)
  • Regency Hospital - Florence

    Regency Hospital - Florence

    11 days ago

    Registered nurse (rn) / prn

    Overview Position: Registered Nurse (RN) Location: Regency Hospital - Florence Schedule: PRN/Per Diem - 12 hour shifts - Nights Compensation: $53.00 per hour Sign-On Bonus: $5,000 Nights Only Regency...

    onsite, Florence, SC, United States
    $107k/yrPart TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    12 days ago

    Registered nurse (rn) acute care, or circulator, ft, days

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Laurens, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    12 days ago

    Physician - travelers rest family medicine

    Inspire health. Serve with compassion. Be the difference. Job Summary The Prisma Health Physician is responsible for the provision of quality medical services to patients of Prisma Health-University...

    onsite, Travelers Rest, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    12 days ago

    Registered nurse (rn) - ambulatory, transcranial magnetic stimulation, behavioral health, ft, days

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides and coordinates nursing care in a non-acute ambulatory, medical office, or urgent care setting in accordance with the...

    onsite, Greenville, SC, United States
    Full TimeEntry with Degree
  • Prisma Health

    Prisma Health

    12 days ago

    Registered nurse (rn) - acute care, multispecialty telemetry, ft, variable

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Greenville, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    12 days ago

    Registered nurse (rn) - acute care, telemetry observation, ft, nights

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Greenville, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    13 days ago

    Registered nurse (rn) - acute care, med/surg/tele, prn, day

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Easley, SC, United States
    Part TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    13 days ago

    Registered nurse (rn) - acute care, med/surg/tele, full time, day

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Easley, SC, United States
    Full TimeJunior (<2 years)
  • Vibra Travels

    Vibra Travels

    14 days ago

    Rn nicu registered nurse traveler

    Facility Type Short Term Acute Care Overview Unlike working for agency after agency, with our travel program, you get to work for a company: Work with 1 recruiter from start to finish and assignment...

    onsite, Greenville, SC, United States
    Full TimeJunior (<2 years)
  • Spartanburg Regional Healthcare System

    Spartanburg Regional Healthcare System

    15 days ago

    Patient transporter (ft nights)- smc

    Job Requirements Position Summary Accurately and efficiently transports patients, wheelchairs, and stretchers to and from nursing units and ancillary departments. Uses transport equipment correctly....

    onsite, Spartanburg, SC, United States
    Full TimeEntry with Degree
  • Prisma Health

    Prisma Health

    16 days ago

    Registered nurse (rn) - ambulatory, internal resource pool, ft, days

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an ambulatory setting under the direction of the physician,...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    20 days ago

    Registered nurse (rn) - prn (as needed)

    Job Description Summary Assist patients in their move toward independence by setting realistic goals and treatment plans. Work as part of a multidisciplinary team and often coordinate patient care...

    onsite, Chester, SC, United States
    Part TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    22 days ago

    Nurse navigator - inpatient oncology transitions navigator

    Job Description Summary The Oncology Nurse Navigator is a professional registered nurse with oncology knowledge who provides individualized support to patients and caregivers to overcome healthcare...

    onsite, Charleston, SC, United States
    Full TimeMiddle (2-4 years)
  • PruittHealth

    PruittHealth

    23 days ago

    Registered nurse-prn

    REGISTERED NURSE-PRN Join the PruittHealth family, where the health and safety of our workforce is our top priority! We're not only committed to your career, we're committed to the health and safety...

    onsite, Columbia, SC, United States
    Part TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    23 days ago

    Registered nurse (rn) acute, childrens emergency, ft, night

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Greenville, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    a month ago

    Registered nurse (rn) - acute care, short stay surgical, ft, nights

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Greenville, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    a month ago

    Registered nurse (rn) - acute care, short stay surgical, prn, days

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Greenville, SC, United States
    Part TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    a month ago

    Registered nurse (rn) - acute care, emergency room, full time, night

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Seneca, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    a month ago

    Registered nurse (rn) - acute care, transplant and intermediate care, prn, nights

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Greenville, SC, United States
    Part TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    a month ago

    Registered nurse (rn)-acute care, facility resource pool, critical care, pt, varied shifts

    Inspire health. Serve with compassion. Be the difference. Job Summary Working for the Facility Resource Pool, provides clinical direction for all aspects of patient care in an acute inpatient...

    onsite, Columbia, SC, United States
    Part TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    a month ago

    Registered nurse (rn)-acute care, facility resource pool, critical care, prn, varied shifts

    Inspire health. Serve with compassion. Be the difference. Job Summary Working for the Facility Resource Pool, provides clinical direction for all aspects of patient care in an acute inpatient...

    onsite, Columbia, SC, United States
    Part TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    a month ago

    Registered nurse (rn)-acute care, facility resource pool, critical care, ft, nights

    Inspire health. Serve with compassion. Be the difference. Job Summary Working for the Facility Resource Pool, provides clinical direction for all aspects of patient care in an acute inpatient...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)

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