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  1. Onsite Jobs
  2. South Dakota
  3. Sioux Falls
  4. Registered Nurse

Onsite Registered Nurse jobs in Sioux Falls, South Dakota, USA

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      Sarah Jenkins

    • 2:30 PM - 3:00 PM

      Initial Interview

      Alex Chen

  • Mon
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      Product Manager Interview

      David G. (Hiring Manager)

    • 4:15 PM - 5:15 PM

      First Round Interview

      Sophie L.

  • Tue
    • 1:20 PM - 1:45 PM

      Introductory Interview

      Marta W.

    • 2:30 PM - 3:00 PM

      Kick-off Interview

      Daria (HR)

  • Wed
    • 1:00 PM - 1:45 PM

      Qualifying Interview

      James Miller

    • 5:30 PM - 6:00 PM

      Discovery Interview

      Chris V.

  • Thu
    • 2:30 PM - 3:00 PM

      First Interview

      Michael T.

    • 4:00 PM - 5:00 PM

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Registered Nurse Jobs in Sioux Falls — On-Site Opportunities Await

Sioux Falls hospitals and clinics are actively seeking skilled healthcare professionals to join their growing teams. With 159 open positions available, this on-site role offers a chance to make a direct impact on patient care in South Dakota's largest city. Registered nurse jobs in Sioux Falls continue to rise as the healthcare sector expands to meet community needs.

Successful candidates bring strong clinical judgment, excellent communication skills, and the ability to thrive under pressure. Employers look for professionals who demonstrate compassion, attention to detail, and proficiency with electronic health records and modern medical technology. A valid license, CPR certification, and a commitment to patient-centered care are essential for anyone hoping to hire a registered nurse in this fast-paced environment.

On-site work remains the standard for this role, as hands-on patient interaction is central to the job. Sioux Falls' healthcare network, including major hospital systems, drives consistent demand for dedicated professionals ready to work directly within clinical settings. The region's growing population and expanding medical facilities make this an ideal time to explore registered nurse vacancies locally.

If you're ready to advance your career, now is the perfect moment to explore new opportunities. Global Work AI connects dedicated professionals with top healthcare employers seeking skilled clinicians ready to make a difference. Discover registered nurse positions tailored to your skills and start the next chapter of your career today.

Frequently Asked
Questions

Everything you need to know about
finding your next role
  • What is the average salary for a registered nurse in Sioux Falls?

    Pay for a registered nurse in Sioux Falls, South Dakota, often falls in the mid-to-high $70,000s annually, with exact figures varying by employer, specialty, and years of experience. Hospitals, outpatient clinics, and long-term care settings may also offer differentials for nights, weekends, or critical care units. Local wages can shift with demand and staffing needs, so checking current Sioux Falls postings gives the clearest picture. Many candidates also compare base pay with benefits such as tuition support, retirement plans, and shift premiums.
  • What qualifications and South Dakota nursing license are required for a registered nurse job?

    Most employers look for an active RN license issued by the South Dakota Board of Nursing, along with an associate or bachelor’s degree in nursing from an accredited program. In practice, passing the NCLEX-RN is essential before practicing in Sioux Falls or anywhere in South Dakota. Some facilities prefer a BSN, especially larger hospital systems, and may ask for Basic Life Support certification or recent clinical experience. If you are coming from another state, review endorsement rules and keep an eye on facility-specific credential requests.
  • What skills do employers look for in a registered nurse?

    Strong bedside communication is only part of the picture; employers in Sioux Falls also value sound clinical judgment, accurate charting, medication safety, and the ability to stay calm under pressure. Teamwork matters in fast-paced hospital units and busy clinics, where nurses coordinate with physicians, aides, and family members. Time management, patient education, and infection-control practices are also important. Many hiring teams look for candidates who can adapt quickly, so it helps to compare the skill mix in current registered nurse listings with your own experience.
  • What does a registered nurse do on a daily basis in a hospital or clinic?

    A typical day often starts with reviewing patient histories, checking vital signs, and prioritizing care plans for the shift. In Sioux Falls hospitals and clinics, a registered nurse may administer medications, start IVs, monitor symptoms, document updates in the chart, and respond to changes in condition. Education is a regular part of the role, whether explaining discharge instructions or helping patients manage treatment at home. Daily tasks depend on the unit, so reviewing specific department postings can show how duties differ across settings.
  • What are the typical shift hours and work conditions for an on-site registered nurse position in Sioux Falls?

    Most on-site roles in Sioux Falls follow 8-hour, 10-hour, or 12-hour schedules, and many hospital jobs include nights, weekends, holidays, or rotating shifts. Clinical settings can be physically demanding, with long periods on your feet, lifting or repositioning patients, and occasional exposure to stressful situations. Some clinics offer more predictable daytime hours, while inpatient units usually need around-the-clock coverage. Shift differentials and unit expectations vary by employer, so it helps to compare listings and note how each one structures work hours.
  • How does the hiring process work for a registered nurse job in Sioux Falls?

    The process usually begins with an online application, followed by a recruiter screen and one or more interviews with nursing leadership. In Sioux Falls, employers often verify your South Dakota RN license, education, work history, references, and any required certifications before making an offer. Some organizations also include skills assessments, background checks, drug screening, and health clearances. Timeline can be quicker for high-need units and longer for specialty departments. Reviewing posting details early can help you prepare documents and understand which steps come next.
  • What career growth opportunities are available for a registered nurse in South Dakota?

    Registered nurse careers in South Dakota can lead to specialties such as ICU, emergency care, labor and delivery, oncology, or perioperative nursing. Many professionals in Sioux Falls also move into charge nurse, preceptor, educator, case management, or nurse leadership roles after building experience. Additional education can open the door to advanced practice pathways, including family nurse practitioner or other graduate-level roles, depending on licensure goals. Certification in a specialty area can strengthen advancement prospects, so it is useful to compare entry-level openings with longer-term career tracks.

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159 jobs found

  • Interim HealthCare - Sioux Falls, SD

    Interim HealthCare - Sioux Falls, SD

    Today

    Registered nurse (rn)

    Who we are: Interim HealthCare is America's leading provider of home care and healthcare staffing. As a family owned, women owned, and veteran owned business, we have been in Sioux Falls the past 34+...

    onsite, Aberdeen, SD, United States
    $91k – $101k/yrPart TimeEntry with Degree
  • Avera Health

    Avera Health

    Today

    Registered nurse (rn) or licensed practical nurse (lpn) | 69th and western clinic

    Location: Avera 69th & Western Clinic Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent upon...

    onsite, Sioux Falls, SD, United States
    $45k – $83k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    Today

    Registered nurse (rn) | behavioral health senior unit

    Location: Avera Behavioral Health Center-Sioux Falls Worker Type: Regular Work Shift: Rotating days/evenings/nights/weekends/holidays (United States of America) Pay Range: The pay range for this...

    onsite, Sioux Falls, SD, United States
    $66k – $98k/yrFull TimeSenior (5+ years)
  • ADVANCED CORRECTIONAL HEALTHCARE

    ADVANCED CORRECTIONAL HEALTHCARE

    2 days ago

    Registered nurse - prn $45-$47/hr

    Job Details: Job Location: Minnehaha County Juvenile Detention Center - Sioux Falls, SD Position Type: PRN Education Level: 2 Year Degree Salary Range: $45.00 - $47.00 Hourly Travel Percentage:...

    onsite, Sioux Falls, SD, United States
    $91k – $95k/yrFull TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    2 days ago

    Rn - registered nurse - stress lab - part time days

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $65k – $97k/yrPart TimeJunior (<2 years)
  • Avera Health

    Avera Health

    2 days ago

    Registered nurse (rn) | endocrinology clinic

    Location: Avera Endocrinology & Diabetes Sioux Falls Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate...

    onsite, Sioux Falls, SD, United States
    $56k – $83k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    3 days ago

    Registered nurse (rn) | or | surgery

    Location: Avera on Louise Health Campus Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent...

    onsite, Sioux Falls, SD, United States
    $62k – $93k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    3 days ago

    Registered nurse (rn) | pediatric endocrinology clinic

    Location: Avera Pediatric Specialists Sioux Falls Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate...

    onsite, Sioux Falls, SD, United States
    $56k – $83k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    3 days ago

    Registered nurse (rn) - new grad - august 2027

    Location: Avera McKennan Hospital Worker Type: Regular Work Shift: Rotating days/evenings/nights/weekends/holidays (United States of America) Pay Range: The pay range for this position is listed...

    onsite, Sioux Falls, SD, United States
    $66k – $98k/yrFull TimeEntry with Degree
  • Avera Health

    Avera Health

    3 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) | hematology & bone marrow transplant clinic

    Location: Hematology, Transplant and Cellular Therapy Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate...

    onsite, Sioux Falls, SD, United States
    $45k – $83k/yrFull TimeJunior (<2 years)
  • Touchmark

    Touchmark

    6 days ago

    Registered nurse

    ETHIC – Excellence, Teamwork, Hospitality, Integrity, and Compassion – steadfastly characterizes our mission to continually enrich the daily lives of residents. We practice these principles with...

    onsite, Sioux Falls, SD, United States
    Full TimeJunior (<2 years)
  • Avera Health

    Avera Health

    6 days ago

    Registered nurse (rn) | surgery

    Location: Avera McKennan Hospital Worker Type: Regular Work Shift: Rotating days/evenings/nights/weekends/holidays (United States of America) Pay Range: The pay range for this position is listed...

    onsite, Sioux Falls, SD, United States
    $66k – $98k/yrFull TimeEntry with Degree
  • Sanford Health

    Sanford Health

    6 days ago

    Rn - registered nurse - pre-experience and recovery care - pre op office - prn

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $65k – $97k/yrPart TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    7 days ago

    Rn - registered nurse - pre-experience and recovery care - prn

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $65k – $97k/yrPart TimeJunior (<2 years)
  • Avera Health

    Avera Health

    8 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) | clinic

    Location: Avera Internal Medicine Cliff Ave Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent...

    onsite, Sioux Falls, SD, United States
    $45k – $83k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    9 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) | gastroenterology clinic | prn

    Location: Avera Gastroenterology Sioux Falls Worker Type: PRN Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent...

    onsite, Sioux Falls, SD, United States
    $45k – $83k/yrPart TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    9 days ago

    Rn - registered nurse - short stay - ft days

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $65k – $97k/yrFull TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    9 days ago

    Rn - registered nurse - critical care float pool - nights

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $65k – $97k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    10 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) or medical assistant | dermatology clinic

    Location: Avera Dermatology Minnesota Ave Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent...

    onsite, Sioux Falls, SD, United States
    $40k – $83k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    10 days ago

    Registered nurse (rn) | psychiatry clinic | prn

    Location: Avera Behavioral Health Sioux Falls Worker Type: PRN Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent...

    onsite, Sioux Falls, SD, United States
    $56k – $83k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    14 days ago

    Registered nurse (rn) | adult psychiatry clinic

    Location: Avera Behavioral Health Sioux Falls Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate...

    onsite, Sioux Falls, SD, United States
    $56k – $83k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    15 days ago

    Registered nurse (rn) | palliative medicine plaza 4

    Location: Avera Palliative Medicine Sioux Falls Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate...

    onsite, Sioux Falls, SD, United States
    $56k – $83k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    16 days ago

    Registered nurse (rn) | nicu

    Location: Avera McKennan Hospital Worker Type: Regular Work Shift: Rotating days/evenings/nights/weekends/holidays (United States of America) Pay Range: The pay range for this position is listed...

    onsite, Sioux Falls, SD, United States
    $66k – $98k/yrFull TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    17 days ago

    Rn - registered nurse - acute care - pt

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $59k – $90k/yrPart TimeJunior (<2 years)
  • Avera Health

    Avera Health

    20 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) | behavioral health child unit

    Location: Avera Behavioral Health Center-Sioux Falls Worker Type: Regular Work Shift: Night Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay...

    onsite, Sioux Falls, SD, United States
    $49k – $98k/yrFull TimeMiddle (2-4 years)
  • Sanford Health

    Sanford Health

    22 days ago

    Rn - registered nurse - birthplace

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $65k – $97k/yrFull TimeEntry with Degree
  • Sanford Health

    Sanford Health

    22 days ago

    Registered nurse - rn - neurosurgery clinic

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $59k – $90k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    23 days ago

    Registered nurse (rn) | pre-post operative

    Location: Avera Surgical Center-Sioux Falls Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent...

    onsite, Sioux Falls, SD, United States
    $62k – $93k/yrPart TimeJunior (<2 years)
  • Avera Health

    Avera Health

    23 days ago

    Registered nurse (rn) | breast health clinic

    Location: Avera Cancer Institute-Sioux Falls Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate...

    onsite, Sioux Falls, SD, United States
    $56k – $83k/yrFull TimeEntry with Degree
  • Avera Health

    Avera Health

    23 days ago

    Registered nurse (rn) | postpartum - gyn

    Location: Avera McKennan Hospital Worker Type: Regular Work Shift: Rotating days/evenings/nights/weekends/holidays (United States of America) Pay Range: The pay range for this position is listed...

    onsite, Sioux Falls, SD, United States
    $66k – $98k/yrPart TimeJunior (<2 years)
  • Avera Health

    Avera Health

    24 days ago

    Registered nurse (rn) | behavioral health adolescent unit | prn

    Location: Avera Behavioral Health Center-Sioux Falls Worker Type: PRN Work Shift: Rotating days/evenings/nights/weekends/holidays (United States of America) Pay Range: The pay range for this position...

    onsite, Sioux Falls, SD, United States
    $66k – $98k/yrPart TimeEntry with Degree
  • Avera Health

    Avera Health

    24 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) | dawley farm pediatrics

    Location: Avera Family Medicine Center Dawley Farm Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate...

    onsite, Sioux Falls, SD, United States
    $45k – $83k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    24 days ago

    Registered nurse (rn) | adult float pool

    Location: Avera McKennan Hospital Worker Type: Regular Work Shift: Rotating days/evenings/nights/weekends/holidays (United States of America) Pay Range: The pay range for this position is listed...

    onsite, Sioux Falls, SD, United States
    $66k – $98k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    a month ago

    Registered nurse (rn) | employee health

    Location: Avera Print Shop Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent upon experience....

    onsite, Sioux Falls, SD, United States
    $56k – $83k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    a month ago

    Registered nurse (rn) or licensed practical nurse (lpn) | transitional care unit

    Location: Avera Prince of Peace-Transitional Care Worker Type: Regular Work Shift: Day/Evening/Weekend/Holiday Shift (United States of America) Pay Range: The pay range for this position is listed...

    onsite, Sioux Falls, SD, United States
    $49k – $98k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    a month ago

    Registered nurse (rn) or licensed practical nurse (lpn) | specialty clinic float

    Location: Plaza 4-Sioux Falls Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent upon...

    onsite, Sioux Falls, SD, United States
    $45k – $64k/yrFull TimeJunior (<2 years)
  • Veterans Health Administration

    Veterans Health Administration

    a month ago

    Registered nurse - associate chief of nursing

    Summary Join the Sioux Falls VA Health Care System as Chief Nurse for Primary and Specialty Medicine Outpatient Integrated Clinical Communities. Lead nursing operations across primary care, specialty...

    onsite, Sioux Falls, SD, United States
    $131k/yrFull TimeDirector
  • Limitless Male

    Limitless Male

    a month ago

    Registered nurse or licensed practical nurse

    About Limitless Male Medical Limitless Male Medical Clinic is a leader in men’s health optimization, focused on helping patients look, feel, and perform at their best. Through personalized care,...

    onsite, Sioux Falls, SD, United States
    Full TimeEntry with Degree
  • Sanford Health

    Sanford Health

    a month ago

    Rn - registered nurse - operating room - or - full time

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $65k – $97k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    a month ago

    Registered nurse (rn) navigator | dialysis

    Location: Avera Dialysis-Sioux Falls Worker Type: Regular Work Shift: Primarily days with possible weekends/evenings/holidays (United States of America) Pay Range: The pay range for this position is...

    onsite, Sioux Falls, SD, United States
    $66k – $98k/yrFull TimeJunior (<2 years)

10,000,000+ more jobs available!