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  2. South Dakota
  3. Registered Nurse

Onsite Registered Nurse jobs in South Dakota, USA

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Registered Nurse Jobs in South Dakota — Explore Rewarding On-Site Opportunities

South Dakota's healthcare facilities are actively expanding their clinical teams, opening 314 registered nurse on-site jobs for dedicated professionals ready to make a difference. This role places caregivers at the heart of patient care, working directly within hospitals and clinics across the state. Demand for skilled clinical staff continues to rise, offering both stability and growth within a supportive clinical environment.

Successful candidates typically bring strong clinical assessment skills, excellent communication, and the ability to remain calm under pressure. Employers seeking to hire a registered nurse often prioritize candidates with current licensure, hands-on experience in patient monitoring, and a solid understanding of electronic health records. Compassion, attention to detail, and the ability to collaborate with multidisciplinary teams are equally valued, as these qualities directly impact patient outcomes and overall care quality.

On-site registered nurse positions in South Dakota involve direct, hands-on patient interaction that remote work simply cannot replicate. Hospitals, clinics, and long-term care facilities throughout the state report steady hiring activity, driven by an aging population and ongoing healthcare expansion. This consistent demand makes South Dakota a promising market for nurses seeking long-term career growth and job security within a close-knit, community-focused healthcare system.

If you're ready to take the next step in your nursing career, now is an excellent time to explore available registered nurse vacancies. Global Work AI connects passionate healthcare professionals with facilities eager to welcome new talent. Discover opportunities that match your skills and start building a rewarding career path today.

Frequently Asked
Questions

Everything you need to know about
finding your next role
  • What is the average registered nurse salary in South Dakota?

    Pay for a registered nurse in South Dakota varies by setting, experience, and shift demand. Recent labor data and employer postings commonly place annual earnings in the low-to-mid $80,000 range, with hospital roles often paying more than long-term care or outpatient settings. Rural locations may differ from larger medical centers, and overtime or night differentials can raise total compensation. Benefits, tuition support, and retirement plans also matter, so it helps to compare current listings across the state before judging a total package.
  • What qualifications are required to become a registered nurse?

    Most employers in the USA expect completion of an approved nursing program, usually an Associate Degree in Nursing or a Bachelor of Science in Nursing, plus successful NCLEX-RN passage. Strong clinical rotations, patient-care experience, and familiarity with electronic health records are valued as well. In South Dakota, hiring managers often look for candidates who can work across fast-paced inpatient or ambulatory care settings. Reviewing local job ads can show whether a facility prefers BSN preparation or specific bedside experience.
  • What licenses and certifications are required for a registered nurse job in South Dakota?

    A current, unencumbered RN license is required to practice in South Dakota, and many employers verify it before an offer is finalized. Depending on the unit, certifications such as Basic Life Support are standard, while Advanced Cardiovascular Life Support, Pediatric Advanced Life Support, or specialty credentials may be needed for emergency, ICU, or pediatrics roles. If you are coming from another state, licensure by endorsement may apply. Checking the facility’s requirements early can save time during the application process.
  • What are the main responsibilities of a registered nurse in a hospital or clinic?

    Day to day, a registered nurse assesses patients, administers medications, monitors vital signs, documents care, and coordinates with physicians, therapists, and other staff. In a South Dakota hospital or clinic, duties may also include patient education, discharge planning, wound care, and responding to changes in condition. The exact mix depends on the department, from med-surg to outpatient specialty care. It is useful to compare posting details carefully, since responsibilities can vary more than the job title suggests.
  • What skills are most important for an on-site registered nurse?

    Strong clinical judgment is essential, but so are communication, time management, and teamwork in a busy on-site environment. Employers in South Dakota also value calm decision-making, infection-control habits, accurate documentation, and comfort with bedside technology. Because patient needs can shift quickly, adaptability and attention to detail make a real difference. Compassion matters too, especially when supporting families and explaining care plans. Looking at current openings can help you see which skills each facility emphasizes most.
  • What is the hiring process for a registered nurse position in South Dakota?

    The process usually starts with an online application, followed by resume screening, an interview, and license verification. Many South Dakota healthcare employers also request references, background checks, immunization records, and proof of required certifications before onboarding. For hospital-based roles, panel interviews or skills questions are common, and some facilities may include a tour of the unit. Timeline can vary from a few days to several weeks, so it helps to keep documents ready and review each listing carefully.
  • What shifts and work conditions should I expect in an on-site registered nurse role?

    On-site nursing schedules often include day, evening, overnight, weekend, and holiday coverage, especially in hospitals and urgent care settings. In South Dakota, some facilities use 12-hour shifts, while clinics may follow more traditional weekday hours. Expect a physically active role with lifting, long periods on your feet, exposure to illness, and a need to respond quickly to changing patient needs. Team coordination and reliable attendance are important, so it is smart to compare shift patterns before applying.

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314 jobs found

  • Avera Health

    Avera Health

    Today

    Registered nurse (rn - iii)|flandreau med surg unit

    Location: Avera Flandreau Hospital Worker Type: Regular Work Shift: Rotating days/evenings/nights/weekends/holidays (United States of America) Pay Range: The pay range for this position is listed...

    onsite, Flandreau, SD, United States
    $66k – $98k/yrFull TimeEntry with Degree
  • Peaceful Pines Senior Living - Spearfish

    Peaceful Pines Senior Living - Spearfish

    Today

    Registered nurse (rn)

    The Registered Nurse (RN) plays a critical role in supporting the health, well-being, and quality of life of residents across Assisted Living and Memory Care. This position is responsible for...

    onsite, Spearfish, SD, United States
    Full TimeJunior (<2 years)
  • JENKINS LIVING CENTER INC

    JENKINS LIVING CENTER INC

    Today

    Registered nurse

    Job Details: Job Location: Jenkins Living Center - Watertown, SD Position Type: Full-Time/Part-Time Education Level: Associates Degree Salary Range: Undisclosed Job Shift: Any Job Category: Nursing...

    onsite, Watertown, SD, United States
    Full TimeJunior (<2 years)
  • Avera Health

    Avera Health

    Today

    Registered nurse (rn) or licensed practical nurse (lpn) | 69th and western clinic

    Location: Avera 69th & Western Clinic Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent upon...

    onsite, Sioux Falls, SD, United States
    $45k – $83k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    Today

    Registered nurse (rn) | behavioral health senior unit

    Location: Avera Behavioral Health Center-Sioux Falls Worker Type: Regular Work Shift: Rotating days/evenings/nights/weekends/holidays (United States of America) Pay Range: The pay range for this...

    onsite, Sioux Falls, SD, United States
    $66k – $98k/yrFull TimeSenior (5+ years)
  • ADVANCED CORRECTIONAL HEALTHCARE

    ADVANCED CORRECTIONAL HEALTHCARE

    2 days ago

    Registered nurse - prn $45-$47/hr

    Job Details: Job Location: Minnehaha County Juvenile Detention Center - Sioux Falls, SD Position Type: PRN Education Level: 2 Year Degree Salary Range: $45.00 - $47.00 Hourly Travel Percentage:...

    onsite, Sioux Falls, SD, United States
    $91k – $95k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    2 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) | long term care

    Location: Avera Majestic Bluffs/Avera Sister James Care Center Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual...

    onsite, Yankton, SD, United States
    $49k – $98k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    2 days ago

    Registered nurse (rn) | women's center

    Location: Avera Queen of Peace Hospital Worker Type: Regular Work Shift: Rotating days/evenings/nights/weekends/holidays (United States of America) Pay Range: The pay range for this position is...

    onsite, Mitchell, SD, United States
    $66k – $98k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    2 days ago

    Registered nurse (rn) | med surg | december 2026 and may 2027 new grad

    Location: Avera St Benedict Hospital Worker Type: Regular Work Shift: Rotating days/evenings/nights/weekends/holidays (United States of America) Pay Range: The pay range for this position is listed...

    onsite, Parkston, SD, United States
    $66k – $98k/yrFull TimeEntry with Degree
  • Avera Health

    Avera Health

    3 days ago

    Registered nurse (rn) | or | surgery

    Location: Avera on Louise Health Campus Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent...

    onsite, Sioux Falls, SD, United States
    $62k – $93k/yrFull TimeJunior (<2 years)
  • Winner Regional Healthcare Center

    Winner Regional Healthcare Center

    3 days ago

    Registered nurse- clinic

    Position Summary: Patient encounters may be face-to-face or via telephone or other communication devices. Assesses the patient’s needs by collecting subjective and objective health status data from...

    onsite, Winner, SD, United States
    Full TimeEntry with Degree
  • Avera Health

    Avera Health

    3 days ago

    Registered nurse (rn - i or rn - iii)|gregory hospital|prn

    Location: Avera Gregory Hospital Worker Type: PRN Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent upon...

    onsite, Gregory, SD, United States
    $56k – $98k/yrPart TimeEntry with Degree
  • Avera Health

    Avera Health

    3 days ago

    Registered nurse (rn) - new grad - august 2027

    Location: Avera McKennan Hospital Worker Type: Regular Work Shift: Rotating days/evenings/nights/weekends/holidays (United States of America) Pay Range: The pay range for this position is listed...

    onsite, Sioux Falls, SD, United States
    $66k – $98k/yrFull TimeEntry with Degree
  • Avera Health

    Avera Health

    3 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) | hematology & bone marrow transplant clinic

    Location: Hematology, Transplant and Cellular Therapy Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate...

    onsite, Sioux Falls, SD, United States
    $45k – $83k/yrFull TimeJunior (<2 years)
  • Keystone Treatment Center - Canton

    Keystone Treatment Center - Canton

    6 days ago

    Registered nurse (rn) - $5k bonus

    Overview $5,000 Sign-On Bonus for FT Days! (1 Year Commitment) RN Days & Night Shift Opportunity at Keystone Treatment Center Pay Range: $32/hr - $48/hr Shifts: 6:30am - 7pm Every third weekend...

    onsite, Canton, SD, United States
    $65k – $97k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    6 days ago

    Registered nurse (rn) | pre-post operative

    Location: Avera Sacred Heart Hospital Worker Type: Regular Work Shift: Primarily days with night, weekend and holiday on-call involvement (United States of America) Pay Range: The pay range for this...

    onsite, Yankton, SD, United States
    $66k – $98k/yrPart TimeJunior (<2 years)
  • Avera Health

    Avera Health

    6 days ago

    Registered nurse (rn) | surgery

    Location: Avera McKennan Hospital Worker Type: Regular Work Shift: Rotating days/evenings/nights/weekends/holidays (United States of America) Pay Range: The pay range for this position is listed...

    onsite, Sioux Falls, SD, United States
    $66k – $98k/yrFull TimeEntry with Degree
  • Sanford Health

    Sanford Health

    6 days ago

    Rn - registered nurse - pre-experience and recovery care - pre op office - prn

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $65k – $97k/yrPart TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    7 days ago

    Rn - registered nurse - pre-experience and recovery care - prn

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $65k – $97k/yrPart TimeJunior (<2 years)
  • Avera Health

    Avera Health

    8 days ago

    Registered nurse (rn) or licensed practical nurse (lpn or medical assistant | pediatric clinic

    Location: Avera Pediatrics Mitchell Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent upon...

    onsite, Mitchell, SD, United States
    $40k – $83k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    8 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) |long term care | prn

    Location: Avera St Benedict Nursing Home Worker Type: PRN Work Shift: Rotating days/evenings/nights/weekends (United States of America) Pay Range: The pay range for this position is listed below....

    onsite, Parkston, SD, United States
    $66k – $98k/yrPart TimeJunior (<2 years)
  • Avera Health

    Avera Health

    9 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) | gastroenterology clinic | prn

    Location: Avera Gastroenterology Sioux Falls Worker Type: PRN Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent...

    onsite, Sioux Falls, SD, United States
    $45k – $83k/yrPart TimeJunior (<2 years)
  • Avera Health

    Avera Health

    9 days ago

    Registered nurse (rn) | prn

    Location: Tyndall, SD Worker Type: PRN Work Shift: As Needed (United States of America) St. Michael’s Hospital Avera is looking for individuals to join our positive and team-oriented organization. We...

    onsite, Tyndall, SD, United States
    Full TimeJunior (<2 years)
  • Avera Health

    Avera Health

    9 days ago

    Registered nurse (rn) | long term care

    Location: Avera Majestic Bluffs/Avera Sister James Care Center Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual...

    onsite, Yankton, SD, United States
    $66k – $98k/yrFull TimeEntry with Degree
  • Sanford Health

    Sanford Health

    9 days ago

    Rn - registered nurse - short stay - ft days

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $65k – $97k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    10 days ago

    Registered nurse (rn) | psychiatry clinic | prn

    Location: Avera Behavioral Health Sioux Falls Worker Type: PRN Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent...

    onsite, Sioux Falls, SD, United States
    $56k – $83k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    14 days ago

    Registered nurse (rn) | adult psychiatry clinic

    Location: Avera Behavioral Health Sioux Falls Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate...

    onsite, Sioux Falls, SD, United States
    $56k – $83k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    14 days ago

    Registered nurse (rn) | podiatry clinic

    Location: Avera Podiatry Yankton Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent upon...

    onsite, Yankton, SD, United States
    $56k – $83k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    15 days ago

    Registered nurse (rn) | palliative medicine plaza 4

    Location: Avera Palliative Medicine Sioux Falls Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate...

    onsite, Sioux Falls, SD, United States
    $56k – $83k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    19 days ago

    Registered nurse (rn) | womens and childrens unit

    Location: Avera Sacred Heart Hospital Worker Type: Regular Work Shift: Rotating days/evenings/nights/weekends/holidays (United States of America) Pay Range: The pay range for this position is listed...

    onsite, Yankton, SD, United States
    $66k – $98k/yrFull TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    22 days ago

    Rn - registered nurse - birthplace

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $65k – $97k/yrFull TimeEntry with Degree
  • Avera Health

    Avera Health

    23 days ago

    Registered nurse (rn) | breast health clinic

    Location: Avera Cancer Institute-Sioux Falls Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate...

    onsite, Sioux Falls, SD, United States
    $56k – $83k/yrFull TimeEntry with Degree
  • Avera Health

    Avera Health

    23 days ago

    Registered nurse (rn) | postpartum - gyn

    Location: Avera McKennan Hospital Worker Type: Regular Work Shift: Rotating days/evenings/nights/weekends/holidays (United States of America) Pay Range: The pay range for this position is listed...

    onsite, Sioux Falls, SD, United States
    $66k – $98k/yrPart TimeJunior (<2 years)
  • Avera Health

    Avera Health

    24 days ago

    Registered nurse (rn) | behavioral health adolescent unit | prn

    Location: Avera Behavioral Health Center-Sioux Falls Worker Type: PRN Work Shift: Rotating days/evenings/nights/weekends/holidays (United States of America) Pay Range: The pay range for this position...

    onsite, Sioux Falls, SD, United States
    $66k – $98k/yrPart TimeEntry with Degree
  • Avera Health

    Avera Health

    24 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) | dawley farm pediatrics

    Location: Avera Family Medicine Center Dawley Farm Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate...

    onsite, Sioux Falls, SD, United States
    $45k – $83k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    a month ago

    Registered nurse (rn) or licensed practical nurse (lpn) | transitional care unit

    Location: Avera Prince of Peace-Transitional Care Worker Type: Regular Work Shift: Day/Evening/Weekend/Holiday Shift (United States of America) Pay Range: The pay range for this position is listed...

    onsite, Sioux Falls, SD, United States
    $49k – $98k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    a month ago

    Registered nurse (rn) or licensed practical nurse (lpn) | specialty clinic float

    Location: Plaza 4-Sioux Falls Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent upon...

    onsite, Sioux Falls, SD, United States
    $45k – $64k/yrFull TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    a month ago

    Rn - registered nurse - operating room - or - full time

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $65k – $97k/yrFull TimeJunior (<2 years)
  • Great Plains Tribal Leaders Health

    Great Plains Tribal Leaders Health

    a month ago

    Registered nurse (rn) i

    Position Title: Registered Nurse Division: OHC Reports To: Clinic Manager Direct Reports: N/A Job Summary: This position is responsible for providing direct patient care providing the highest quality...

    onsite, Rapid City, SD, United States
    Full TimeJunior (<2 years)
  • Avera Health

    Avera Health

    a month ago

    Registered nurse (rn) | icu

    Location: Avera Queen of Peace Hospital Worker Type: Regular Work Shift: Rotating days/evenings/nights/weekends/holidays (United States of America) Pay Range: The pay range for this position is...

    onsite, Mitchell, SD, United States
    $66k – $98k/yrFull TimeJunior (<2 years)

10,000,000+ more jobs available!