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  1. Onsite Jobs
  2. South Carolina
  3. Charleston
  4. Registered Nurse

Onsite Registered Nurse jobs in Charleston, South Carolina, USA

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Registered Nurse Jobs in Charleston — On-Site Opportunities Await

Charleston's healthcare facilities are actively seeking dedicated professionals to fill 256 on-site registered nurse jobs in Charleston, South Carolina. As the region's medical network continues to expand, hospitals and clinics need skilled caregivers who can deliver compassionate, high-quality patient care. This growing demand makes now an excellent time to explore registered nurse vacancies in this vibrant coastal city.

Successful candidates typically bring strong clinical judgment, excellent communication skills, and the ability to manage multiple patients under pressure. Proficiency in electronic health records, medication administration, and patient education is essential, along with current licensure and CPR certification. Employers seeking to hire a registered nurse often look for adaptability, empathy, and a collaborative spirit that supports interdisciplinary teams across diverse care settings.

On-site roles in Charleston place nurses directly within hospital units, outpatient centers, and specialty clinics, allowing for hands-on patient interaction and immediate teamwork with physicians. South Carolina's healthcare sector continues to see steady hiring momentum, driven by population growth and expanding medical infrastructure along the coast. This local demand creates consistent opportunities for both experienced practitioners and those new to the field.

If you're ready to advance your nursing career in a supportive, patient-focused environment, now is the perfect moment to pursue registered nurse positions in Charleston. Browse current listings on Global Work AI and take the next step toward a rewarding role where your skills truly make a difference.

Frequently Asked
Questions

Everything you need to know about
finding your next role
  • What is the average salary for a registered nurse in Charleston?

    In Charleston, South Carolina, pay for a registered nurse usually falls in the middle of the Southeast market, with many hospital roles landing around the low-to-mid $70,000s annually, depending on specialty, experience, and employer. Local wages can rise with night differentials, weekend coverage, critical care exposure, or advanced certifications. Larger health systems in Charleston may also offer shift premiums and sign-on incentives, which can change the total package. It helps to compare posted ranges with current listings and benefits before deciding where your skills fit best.
  • What qualifications and nursing license are required for a registered nurse job in Charleston?

    Most Charleston employers expect an accredited ADN or BSN, successful completion of NCLEX-RN, and an active South Carolina RN license or multistate compact privilege when eligible. Hospitals may also ask for BLS certification, and some units prefer ACLS, PALS, or specialty training such as ICU or telemetry. Background checks, immunization records, and recent clinical experience are also common during screening. Because licensure and facility standards can vary, it is wise to review each posting carefully and check how your credentials align with the unit’s needs.
  • What skills do employers look for in a registered nurse?

    Hiring teams in Charleston look for more than clinical knowledge; they want a registered nurse who communicates clearly, stays organized under pressure, and makes sound decisions in fast-moving settings. Strong assessment ability, safe medication administration, EHR documentation, teamwork, and patient education are central in hospital environments. Many employers also value empathy, adaptability, and calm problem-solving, especially on busy inpatient floors. If you are preparing materials for applications, it helps to match examples of these strengths to the exact specialty and patient population listed.
  • What are the main responsibilities of a registered nurse in an on-site hospital role?

    Day-to-day work in a Charleston hospital usually includes patient assessment, medication administration, treatment monitoring, care planning, charting, and coordination with physicians, therapists, and support staff. A registered nurse may also start IVs, manage wound care, prep patients for procedures, and respond to changes in condition. On-site roles require close collaboration with the care team, so communication and quick escalation matter just as much as technical tasks. Reviewing unit-specific duties can help you understand whether the role fits your background and long-term goals.
  • What does the hiring process look like for a registered nurse position in Charleston?

    The process often starts with an online application, followed by recruiter review, a phone screen, and one or more interviews with nurse leaders or unit managers. In Charleston, hospitals may also request license verification, skills checklists, reference checks, and a pre-employment health screen before extending an offer. For specialty units, a clinical interview or simulation-based step is common. Timelines can move quickly when staffing needs are urgent, so it helps to keep credentials updated and monitor related openings as you search.
  • What shift patterns and work conditions should I expect in an on-site registered nurse job?

    Most hospital-based roles in Charleston use 12-hour shifts, often with day, night, or rotating schedules, and some units add weekend, holiday, or on-call coverage. Work conditions can be physically demanding, with frequent standing, lifting, fast pace, and exposure to high-acuity situations. Nurses may work in units such as med-surg, ICU, ER, or post-op recovery, each with its own rhythm and staffing model. Before applying, it is useful to compare schedules, staffing ratios, and differential pay so you can choose a setting that matches your lifestyle.
  • How can a registered nurse grow into charge nurse, nurse manager, or clinical leadership roles?

    Growth usually comes from steady bedside performance, mentoring newer staff, and building a reputation for reliable judgment and strong communication. In Charleston hospitals, nurses who pursue certifications, quality improvement projects, committee work, and informal preceptor duties often gain visibility for leadership openings. A BSN can strengthen advancement prospects, and some employers prefer graduate study for nurse manager or clinical coordinator paths. Taking on charge shifts, learning staffing workflows, and developing unit-level problem-solving skills can help you move toward the next stage and compare leadership tracks across employers.

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256 jobs found

  • Medical University of South Carolina

    Medical University of South Carolina

    2 days ago

    Registered nurse i - art 4e cardiothoracic stepdown unit

    Job Description Summary Under general supervision, the Registered Nurse I (New Graduate) assists at the advanced beginner level in providing individualized, goal directed nursing care to patients and...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Roper St. Francis Healthcare

    Roper St. Francis Healthcare

    2 days ago

    Registered nurse (rn) - cardiac post procedure - roper hospital

    Thank you for considering a career at Roper St. Francis Healthcare! Scheduled Weekly Hours: 36 Work Shift: Days/Evenings (United States of America) Seeking prior cardiac RN experience Summary of...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • AdamsPlace

    AdamsPlace

    3 days ago

    Rn registered nurse

    Position: Registered Nurse (RN) Are you looking to make a difference in the lives of others by sharing your care and compassion? Do you enjoy connecting with your patients while getting to know them...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    6 days ago

    Registered nurse ii-labor and delivery

    Job Description Summary MUSC delivers approximately 3,600 patients annually. Labor and Delivery, consists of 17 LDRs, 2 ORs, 3 PACU beds, and 4 Triage rooms. In addition to vaginal and cesarean...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    6 days ago

    Registered nurse i (new grad) - main operating room

    Job Description Summary The Main Operating Room is within a level one, academic trauma center. There are 21- OR suites which cover all surgical specialties, to include, Trauma, Transplant, Ortho,...

    onsite, Charleston, SC, United States
    Full TimeEntry with Degree
  • HCA Healthcare

    HCA Healthcare

    6 days ago

    Quality risk registered nurse

    Are you passionate about the patient experience? At HCA Healthcare, we are committed to caring for patients with purpose and integrity. We care like family! Jump-start your career as a Quality Risk...

    onsite, Charleston, SC, United States
    Part TimeLead / Manager
  • Roper St. Francis Healthcare

    Roper St. Francis Healthcare

    8 days ago

    Registered nurse (rn) — nephrology — roper hospital

    Thank you for considering a career at Roper St. Francis Healthcare! Scheduled Weekly Hours: 36 Work Shift: Nights (United States of America) Shift Schedule: 3x - 12 Hours Shift per week 7:00 PM to...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Roper St. Francis Healthcare

    Roper St. Francis Healthcare

    8 days ago

    Registered nurse (rn) - rehab med surg - roper hospital - 3 west - weekend only

    Thank you for considering a career at Roper St. Francis Healthcare! Scheduled Weekly Hours: 36 Work Shift: Days/Evenings (United States of America) Summary of Primary Function Delivers patient care...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Roper St. Francis Healthcare

    Roper St. Francis Healthcare

    8 days ago

    Registered nurse (rn) weekend only – nephrology – roper hospital

    Thank you for considering a career at Roper St. Francis Healthcare! Scheduled Weekly Hours: 36 Work Shift: Days (United States of America) Summary of Primary Function Delivers patient care utilizing...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Roper St. Francis Healthcare

    Roper St. Francis Healthcare

    8 days ago

    Registered nurse (rn) — cardiac intermediate care — roper hospital

    Thank you for considering a career at Roper St. Francis Healthcare! Scheduled Weekly Hours: 36 Work Shift: Evenings/Nights (United States of America) Shift Hours: 7:00pm - 7:30am including rotating...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Roper St. Francis Healthcare

    Roper St. Francis Healthcare

    8 days ago

    Registered nurse (rn) - med surg - bon secours st. francis hospital

    Thank you for considering a career at Roper St. Francis Healthcare! Scheduled Weekly Hours: 36 Work Shift: Nights (United States of America) Summary of Primary Function Delivers patient care...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Roper St. Francis Healthcare

    Roper St. Francis Healthcare

    8 days ago

    Registered nurse (rn) - med surg urology - bon secours st. francis hospital

    Thank you for considering a career at Roper St. Francis Healthcare! Scheduled Weekly Hours: 36 Work Shift: Days (United States of America) Summary of Primary Function Delivers patient care utilizing...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Roper St. Francis Healthcare

    Roper St. Francis Healthcare

    8 days ago

    Registered nurse (rn) - medical intermediate care/hospitalist - roper hospital

    Thank you for considering a career at Roper St. Francis Healthcare! Scheduled Weekly Hours: 36 Work Shift: Nights (United States of America) Shift Schedule: 3 night shifts a week 7:00pm-7:30am ,...

    onsite, Charleston, SC, United States
    Full TimeMiddle (2-4 years)
  • Roper St. Francis Healthcare

    Roper St. Francis Healthcare

    9 days ago

    Registered nurse (rn) - cardiac intermediate care - roper hospital

    Thank you for considering a career at Roper St. Francis Healthcare! Scheduled Weekly Hours: 0.01 Work Shift: Days/Evenings (United States of America) Shift Hours: PRN (as needed, non-benefited)...

    onsite, Charleston, SC, United States
    Part TimeEntry with Degree
  • Roper St. Francis Healthcare

    Roper St. Francis Healthcare

    10 days ago

    Registered nurse (rn) - operating room (or) - roper hospital

    Thank you for considering a career at Roper St. Francis Healthcare! Scheduled Weekly Hours: 40 Work Shift: Days/Evenings (United States of America) Shift/hours: Monday through Friday 0700 to 1530...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Roper St. Francis Healthcare

    Roper St. Francis Healthcare

    12 days ago

    Registered nurse (rn) – nephrology – roper hospital

    Thank you for considering a career at Roper St. Francis Healthcare! Scheduled Weekly Hours: 36 Work Shift: Days (United States of America) Summary of Primary Function Delivers patient care utilizing...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    13 days ago

    Registered nurse ii- 7e medical acute care

    Job Description Summary Under general supervision, the Registered Nurse II provides individualized, goal-directed patient care to families and patients at the competent level utilizing the principles...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • DaVita Kidney Care

    DaVita Kidney Care

    13 days ago

    Registered nurse

    Posting Date 10/16/2026 1964 Ashley River Rd Ste D-3, Charleston, South Carolina, 29407-4782, United States of America Make a real impact—every day. As a DaVita RN, you’ll ensure compassionate and...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Roper St. Francis Healthcare

    Roper St. Francis Healthcare

    14 days ago

    Registered nurse (rn) - master social worker (msw) case manager - bon secours st. francis hospital - prn

    Thank you for considering a career at Roper St. Francis Healthcare! Scheduled Weekly Hours: 0.01 Work Shift: Days (United States of America) HOURS: As Needed, 8:00am - 4:30pm LOCATION: Will work at...

    onsite, Charleston, SC, United States
    Part TimeJunior (<2 years)
  • Roper St. Francis Healthcare

    Roper St. Francis Healthcare

    15 days ago

    Registered nurse (rn) - nsg bone marrow transplant - roper hospital

    Thank you for considering a career at Roper St. Francis Healthcare! Scheduled Weekly Hours: 36 Work Shift: Nights (United States of America) Summary of Primary Function Delivers patient care...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Sono Bello

    Sono Bello

    15 days ago

    Registered nurse

    Sono Bello is America's top cosmetic surgery specialist, with 185+ board-certified surgeons who have performed over 300,000 laser liposuction and body contouring procedures. A career at Sono Bello...

    onsite, Charleston, SC, United States
    $56k – $71k/yrFull TimeJunior (<2 years)
  • Roper St. Francis Healthcare

    Roper St. Francis Healthcare

    16 days ago

    Registered nurse (rn) - labor and delivery - bon secours st. francis hospital

    Thank you for considering a career at Roper St. Francis Healthcare! Scheduled Weekly Hours: 36 Work Shift: Nights (United States of America) Shift Hours: 7:00pm - 7:30am including rotating weekends...

    onsite, Charleston, SC, United States
    Full TimeEntry with Degree
  • Roper St. Francis Healthcare

    Roper St. Francis Healthcare

    17 days ago

    Registered nurse (rn) — labor and delivery - bon secours st. francis hospital

    Thank you for considering a career at Roper St. Francis Healthcare! Scheduled Weekly Hours: 24 Work Shift: Nights (United States of America) Shift Hours: 7:00pm - 7:30am Seeking at least 1 year prior...

    onsite, Charleston, SC, United States
    Part TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    17 days ago

    Registered nurse i or ii - art or

    Job Description Summary Ashley River Tower (ART) perioperative services is located on the fourth floor of the ART building. The ART operating room offers adult outpatient and inpatient surgeries...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Roper St. Francis Healthcare

    Roper St. Francis Healthcare

    20 days ago

    Registered nurse (rn) - preop and post-anesthesia care unit (pacu) - roper hospital

    Thank you for considering a career at Roper St. Francis Healthcare! Scheduled Weekly Hours: 36 Work Shift: Days/Evenings (United States of America) Shift/Schedule: Monday - Friday, Preop shifts 6:00...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    20 days ago

    Registered nurse i - (new graduate) - art 4e cardiothoracic stepdown unit

    Job Description Summary Under general supervision, the Registered Nurse I (New Graduate) assists at the advanced beginner level in providing individualized, goal directed nursing care to patients and...

    onsite, Charleston, SC, United States
    Full TimeEntry with Degree
  • Medical University of South Carolina

    Medical University of South Carolina

    20 days ago

    Registered nurse i (new graduate) or registered nurse ii - 9w neurology/neurosurgery

    Job Description Summary Under general supervision, the Registered Nurse I assists at the advanced beginner level in providing individualized, goal directed nursing care to patients and families...

    onsite, Charleston, SC, United States
    Full TimeEntry with Degree
  • Roper St. Francis Healthcare

    Roper St. Francis Healthcare

    21 days ago

    Registered nurse (rn) weekend only plan — cardiac intermediate care — roper hospital

    Thank you for considering a career at Roper St. Francis Healthcare! Scheduled Weekly Hours: 24 Work Shift: Days/Evenings (United States of America) Shift Hours: 7:00am - 7:30pm Saturday and Sunday...

    onsite, Charleston, SC, United States
    Part TimeJunior (<2 years)
  • Fresenius Medical Care

    Fresenius Medical Care

    23 days ago

    Outpatient registered nurse - rn

    PURPOSE AND SCOPE: The professional registered nurse Outpatient RN CAP 1 is an entry level designation into the Clinical Advancement Program (CAP). This position is accountable and responsible for...

    onsite, Charleston, SC, United States
    Full TimeLead / Manager
  • Roper St. Francis Healthcare

    Roper St. Francis Healthcare

    23 days ago

    Registered nurse (rn) - emergency department (ed) - roper hospital - weekend only

    Thank you for considering a career at Roper St. Francis Healthcare! Scheduled Weekly Hours: 36 Work Shift: Days (United States of America) Primary Function/General Purpose of Position To provide...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Roper St. Francis Healthcare

    Roper St. Francis Healthcare

    23 days ago

    Registered nurse (rn) - emergency department (ed) - roper hospital

    Thank you for considering a career at Roper St. Francis Healthcare! Scheduled Weekly Hours: 36 Work Shift: Evenings/Nights (United States of America) Shift Schedule 1:00 PM to 1:00 AM Summary of...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Roper St. Francis Healthcare

    Roper St. Francis Healthcare

    23 days ago

    Registered nurse (rn) - emergency department (ed) - roper hospital - prn

    Thank you for considering a career at Roper St. Francis Healthcare! Scheduled Weekly Hours: 0.01 Work Shift: Rotating Shifts (United States of America) Summary of Primary Function Delivers patient...

    onsite, Charleston, SC, United States
    Part TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    24 days ago

    Registered nurse i (fall 2026 new grad blitz) - main 9c short stay

    Job Description Summary Located at MUSC Health’s main hospital, 9 Center is a nine-bed ER overflow, Admission and Holding unit open 24/7. 9Center is designed to help alleviate boarding in the...

    onsite, Charleston, SC, United States
    Full TimeEntry with Degree
  • Medical University of South Carolina

    Medical University of South Carolina

    24 days ago

    Registered nurse i (fall 2026 new grad blitz) - 7e medical acute care

    Job Description Summary 7East Medical Acute Care Unit is a 26-bed inpatient Medical-Surgical Unit which provides care to an adult and geriatric patient population. 7East is identified as the...

    onsite, Charleston, SC, United States
    $44k/yrFull TimeEntry with Degree
  • Medical University of South Carolina

    Medical University of South Carolina

    24 days ago

    Registered nurse i (fall 2026 new grad blitz) - 8d eh acute care

    Job Description Summary Located at MUSC Health’s extension hospital, 8D EH is a 13-bed inpatient adult acute med-surg unit open 24/7. 8D EH is designed to accommodate medical and surgical patients...

    onsite, Charleston, SC, United States
    Full TimeEntry with Degree
  • Medical University of South Carolina

    Medical University of South Carolina

    24 days ago

    Registered nurse i (new grad) - 7e medical acute care

    Job Description Summary Under general supervision, the Registered Nurse I provides individualized, goal-directed patient care to families and patients at the competent level utilizing the principles...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    24 days ago

    Registered nurse (rn) musc leatherman adolescent inpatient prn

    Job Description Summary Awesome PRN opportunity for an experienced nurse interested in Behavioral Health! Apply today or contact Recruiter Shannon Shaw at shawsh@musc.edu or 843-674-2694 for more...

    onsite, Charleston, SC, United States
    Part TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    24 days ago

    Registered nurse i (new grad) - 7a family medicine

    Job Description Summary Under general supervision, the Registered Nurse I provides individualized, goal-directed patient care to families and patients at the competent level utilizing the principles...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Roper St. Francis Healthcare

    Roper St. Francis Healthcare

    a month ago

    Registered nurse (rn) - emergency department (ed) - bon secours st. francis hospital

    Thank you for considering a career at Roper St. Francis Healthcare! Scheduled Weekly Hours: 36 Work Shift: Nights (United States of America) Summary of Primary Function Delivers patient care...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Roper St. Francis Healthcare

    Roper St. Francis Healthcare

    a month ago

    Registered nurse (rn) weekend only – cardiothoracic and vascular intermediate care – roper hospital

    Thank you for considering a career at Roper St. Francis Healthcare! Scheduled Weekly Hours: 36 Work Shift: Nights (United States of America) Summary of Primary Function Delivers patient care...

    onsite, Charleston, SC, United States
    Full TimeMiddle (2-4 years)

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