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  1. Onsite Jobs
  2. South Carolina
  3. Registered Nurse

Onsite Registered Nurse jobs in South Carolina, USA

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Min. salary, $/year
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      Sarah Jenkins

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      Alex Chen

  • Mon
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      David G. (Hiring Manager)

    • 4:15 PM - 5:15 PM

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      Sophie L.

  • Tue
    • 1:20 PM - 1:45 PM

      Introductory Interview

      Marta W.

    • 2:30 PM - 3:00 PM

      Kick-off Interview

      Daria (HR)

  • Wed
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      Qualifying Interview

      James Miller

    • 5:30 PM - 6:00 PM

      Discovery Interview

      Chris V.

  • Thu
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      Michael T.

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Registered Nurse Jobs in South Carolina — On-Site Opportunities Await

Healthcare facilities across South Carolina are actively seeking dedicated nurses to join their on-site teams, with 500+ open positions available right now. The demand for registered nurse jobs in South Carolina continues to grow as hospitals and clinics expand patient care services. This fast-paced sector offers a chance to make a tangible difference every day.

Successful candidates bring strong clinical judgment, excellent communication skills, and the ability to manage multiple patients under pressure. Employers look for proficiency in electronic health records, medication administration, and compassionate bedside manner. Whether entering the field or advancing a career, nurses who stay current with best practices and certifications remain highly competitive for registered nurse positions in today's evolving healthcare landscape.

On-site work remains the standard for this profession, as direct patient interaction and hands-on care cannot be replicated remotely. South Carolina's healthcare systems, from regional hospitals to specialized clinics, continue to report a steady hiring outlook, reflecting the state's growing population and healthcare investment. Facilities are eager to hire a registered nurse who can adapt to varied shifts and collaborative care environments.

If you're ready to take the next step in your nursing career, now is the perfect time to explore registered nurse vacancies across South Carolina. Global Work AI connects passionate professionals with facilities eager to welcome new talent. Discover opportunities that match your skills and start making an impact in patient care today.

Frequently Asked
Questions

Everything you need to know about
finding your next role
  • What is the average salary for a registered nurse in South Carolina?

    In South Carolina, pay for a registered nurse commonly falls below the national average, though it varies by employer, specialty, and years of experience. Current market data often places annual earnings in a broad range around the low-to-mid $70,000s, with larger health systems and specialty units sometimes offering more. Urban hospitals, travel-friendly shifts, and high-demand departments can improve compensation. Benefits such as shift differentials, retirement plans, and tuition support also matter when comparing offers, so it helps to review updated listings and local wage reports together.
  • What qualifications and RN license are required to work as a registered nurse in South Carolina?

    To work as a registered nurse in South Carolina, candidates typically need an associate or bachelor’s degree in nursing from an approved program and successful completion of the NCLEX-RN exam. A current South Carolina RN license, or eligibility for licensure by endorsement if already licensed elsewhere in the USA, is required before practicing. Employers usually expect CPR certification and may prefer prior clinical experience. Because hospital policies can differ, it is wise to confirm the exact license status, education background, and onboarding documents before moving forward with applications.
  • What skills are most important for a registered nurse in a hospital setting?

    Strong clinical judgment is essential in a hospital environment, especially when patient conditions change quickly. A successful registered nurse also needs solid communication, careful medication administration, accurate charting, and the ability to work calmly with physicians, aides, and families. Time management and prioritization are especially important on busy South Carolina units where multiple patients need attention at once. Familiarity with electronic health records, infection control, and teamwork also stands out to employers. Reviewing current hospital openings can help you see which abilities are emphasized most often.
  • What are the main responsibilities of a registered nurse on-site?

    Day-to-day work on-site usually centers on assessing patients, creating and following care plans, giving medications, monitoring vital signs, and responding to changes in condition. A registered nurse may also coordinate with providers, support admissions and discharges, and document care accurately in the medical record. In South Carolina hospitals and clinics, responsibility can extend to patient education, safety checks, and handoff communication between shifts. Because expectations differ by unit, checking each posting closely can clarify whether the role leans toward acute care, step-down, or outpatient support.
  • What patient care duties are expected in a registered nurse role in South Carolina?

    Patient-facing duties often include wound care, IV therapy, pain assessment, mobility assistance, and ongoing monitoring of symptoms or lab results. In South Carolina, a registered nurse may also prepare patients for procedures, explain treatment plans, and teach families about recovery steps at home. Safety, infection prevention, and accurate reporting are central to every shift. Depending on the setting, duties may also involve triage or coordination with therapists and case managers. Reviewing local job descriptions can show how these responsibilities shift between hospitals, surgery centers, and long-term care settings.
  • What does the hiring process look like for a registered nurse position?

    Most employers start with an application and resume review, followed by one or more interviews focused on clinical experience, teamwork, and problem-solving. Many healthcare systems in South Carolina also verify licensure, immunizations, references, and background information before extending an offer. Some roles include skills testing, a unit tour, or shadowing with staff. After selection, onboarding often covers orientation, documentation, and policy training. Since timelines vary by facility, it helps to compare openings and prepare your credentials early so you can move quickly when a strong match appears.
  • What career growth opportunities are available for a registered nurse in the USA?

    Across the USA, a registered nurse can move into specialized areas such as critical care, emergency nursing, oncology, pediatrics, or perioperative services. Many professionals also advance into charge nurse, nurse educator, case management, informatics, or leadership roles. In South Carolina, employers may support continuing education, certification, and tuition assistance for those aiming higher. With additional schooling, some nurses pursue advanced practice paths like nurse practitioner or clinical nurse specialist. Exploring job boards and comparing specialties can help you map the next step based on interests and long-term goals.

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500+ jobs found

  • Prisma Health

    Prisma Health

    a day ago

    Registered nurse (rn)- ambulatory, heritage pediatrics and internal medicine, ft, day

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides and coordinates nursing care in a non-acute ambulatory, medical office, or urgent care setting in accordance with the...

    onsite, Wren Creek, SC, United States
    Full TimeEntry with Degree
  • Prisma Health

    Prisma Health

    2 days ago

    Registered nurse (rn) - acute care, nicu, full time, night

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Seneca, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    2 days ago

    Registered nurse (rn)-acute care, family beginnings mother baby, ft, nights

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    2 days ago

    Registered nurse (rn) - acute care, family beginnings (postpartum), prn, nights

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Greenville, SC, United States
    Part TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    2 days ago

    Registered nurse (rn) -acute care, transplant and intermediate care unit, ft, day

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Greenville, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    5 days ago

    Registered nurse (rn) acute care, icu, ft, days

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Laurens, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    5 days ago

    Registered nurse (rn) acute care, emergency department, prn, variable

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Greer, SC, United States
    Part TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    5 days ago

    Registered nurse (rn) - acute care, operating room, prn, days

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Greenville, SC, United States
    Part TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    6 days ago

    Registered nurse (rn)-acute care, family beginnings (postpartum), ft, nights

    Inspire health. Serve with compassion. Be the difference. Job Summary Job Profile Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering...

    onsite, Greenville, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    6 days ago

    Registered nurse (rn)-acute care, facility resource pool - med/surg/tele, ft, night

    Inspire health. Serve with compassion. Be the difference. Job Summary Working for the Facility Resource Pool, provides clinical direction for all aspects of patient care in an acute inpatient...

    onsite, Greenville, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    6 days ago

    Registered nurse (rn)-acute, recovery room, prn, day

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Greenville, SC, United States
    Part TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    6 days ago

    Registered nurse (rn)-acute care, emergency department, ft, night

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Greenville, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    6 days ago

    Registered nurse (rn) - acute care, neuroscience & stroke, ft, variable

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Greenville, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    6 days ago

    Registered nurse (rn)-acute, pediatric icu (picu), ft, night

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Greenville, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    7 days ago

    Registered nurse (rn) - outpatient, endoscopy, ft, days

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an outpatient setting. Demonstrates clinical competency utilizing...

    onsite, Greenville, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    7 days ago

    Registered nurse (rn) - acute care, surgical specialty, ft, day

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Greenville, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    8 days ago

    Registered nurse (rn) - acute care, med/surg, full time, day

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Seneca, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    8 days ago

    Registered nurse (rn)-acute care, short stay surgical, ft, day

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Greenville, SC, United States
    Full TimeJunior (<2 years)
  • Spartanburg Regional Healthcare System

    Spartanburg Regional Healthcare System

    8 days ago

    Registered nurse (rn) - icu -restorative care

    Job Requirements Unit Details: TU-ICU Nurse to Patient Ratio-1:2 Beds: 3 Case Types: Drips, Cardiac, Renal Wounds, Trauma Unit Description This position is part of our 3-bed Intensive Care Unit (ICU)...

    onsite, Spartanburg, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    9 days ago

    Registered nurse (rn)-acute care, operating room, prn, night

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Greenville, SC, United States
    Part TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    12 days ago

    Registered nurse (rn) acute care, or circulator, ft, days

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Laurens, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    12 days ago

    Registered nurse (rn) - acute care, general surgery, prn, day

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Greenville, SC, United States
    Part TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    12 days ago

    Registered nurse (rn) acute care, behavioral health, prn, variable

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Greenville, SC, United States
    Part TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    13 days ago

    Registered nurse (rn) - acute care, med/surg/tele, prn, day

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Easley, SC, United States
    Part TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    13 days ago

    Registered nurse (rn) - acute care, med/surg/tele, full time, day

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Easley, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    13 days ago

    Registered nurse (rn) acute care, medical intensive care, ft, nights

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Greer, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    13 days ago

    Registered nurse (rn)-acute care, coronary intervention & recovery, ft, night

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Greenville, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    16 days ago

    Registered nurse (rn)-acute care, icu intermediate, ft, varied shifts

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    19 days ago

    Registered nurse (rn)-acute care, childrens emergency department, ft, night

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Greenville, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    23 days ago

    Registered nurse (rn) - outpatient, gi lab, pt, days

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an outpatient setting. Demonstrates clinical competency utilizing...

    onsite, Greenville, SC, United States
    Part TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    23 days ago

    Registered nurse (rn) - acute care, mental health emergency department, ft, day

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Columbia, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    a month ago

    Registered nurse (rn) - acute care, short stay surgical, ft, nights

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Greenville, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    a month ago

    Registered nurse (rn) - acute care, pacu, full time, variable

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Easley, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    a month ago

    Registered nurse (rn) - acute care, short stay surgical, prn, days

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Greenville, SC, United States
    Part TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    a month ago

    Registered nurse (rn) - acute care, emergency room, full time, night

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Seneca, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    a month ago

    Registered nurse (rn) - acute care, transplant and intermediate care, prn, nights

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Greenville, SC, United States
    Part TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    a month ago

    Registered nurse (rn) - research, department of medicine, ft, days

    Inspire health. Serve with compassion. Be the difference. Job Summary Responsible for the implementation, management and oversight of research studies including the education of research staff,...

    onsite, Greenville, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    a month ago

    Registered nurse (rn) - acute care, surgical specialty, full time, night

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Seneca, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    a month ago

    Registered nurse (rn) - asst nurse manager, surgical specialty, full time, night

    Inspire health. Serve with compassion. Be the difference. Job Summary In collaboration with the nurse manager, supervises staff and unit operations and provides direct patient care. Supervises care...

    onsite, Seneca, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    a month ago

    Registered nurse (rn) acute care, med/surg, prn, days

    Inspire health. Serve with compassion. Be the difference. Job Summary Provides clinical direction for all aspects of patient care in an acute inpatient setting, fostering patient/family centered...

    onsite, Greer, SC, United States
    Part TimeJunior (<2 years)

10,000,000+ more jobs available!