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  2. Iowa
  3. Des Moines
  4. Registered Nurse

Onsite Registered Nurse jobs in Des Moines, Iowa, USA

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      Sarah Jenkins

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      Alex Chen

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      David G. (Hiring Manager)

    • 4:15 PM - 5:15 PM

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      Sophie L.

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      Marta W.

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      Daria (HR)

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      James Miller

    • 5:30 PM - 6:00 PM

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      Chris V.

  • Thu
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      Michael T.

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Registered Nurse Jobs in Des Moines — On-Site Opportunities Await

Des Moines hospitals and clinics are actively seeking dedicated nursing professionals to join their on-site care teams. With 131 open positions available, this is an excellent time to explore registered nurse jobs in Des Moines and contribute to a thriving healthcare community. The growing population and expanding medical facilities in Iowa continue to fuel demand for skilled, compassionate caregivers.

Successful candidates bring strong clinical assessment skills, attention to detail, and the ability to manage multiple patients with empathy and precision. Employers value nurses who demonstrate excellent communication, critical thinking, and proficiency with electronic health records. A current state nursing license, CPR certification, and a commitment to patient-centered care are typically required. Adaptability and teamwork remain essential traits as healthcare settings evolve to meet new challenges.

On-site roles in Des Moines allow nurses to work directly within hospitals, outpatient clinics, and long-term care facilities, fostering hands-on collaboration with physicians and support staff. Iowa's healthcare sector continues to expand, creating steady opportunities for both experienced and newly licensed nurses. Local employers increasingly hire a registered nurse to strengthen patient care teams amid rising community health needs.

If you're ready to advance your nursing career, explore current registered nurse vacancies and discover how your skills can make a difference in Des Moines. Global Work AI connects passionate healthcare professionals with rewarding opportunities, making it easy to find the right fit. Take the next step toward a fulfilling career by reviewing today's registered nurse positions and applying with confidence.

Frequently Asked
Questions

Everything you need to know about
finding your next role
  • What is the average salary for a registered nurse in Des Moines?

    Pay for a registered nurse in Des Moines typically falls around the low-to-mid $70,000s annually, though exact figures vary by unit, experience, certifications, and employer type. Large hospital systems, specialty departments, and night shifts may offer higher compensation, while outpatient clinics can differ. In Iowa, wages often track local demand and statewide healthcare staffing needs, so comparing openings in Des Moines with similar roles in nearby facilities can give a clearer picture. Benefits, shift differentials, and overtime also affect total earnings.
  • What qualifications and Iowa nursing license are required to work as a registered nurse?

    Most employers expect an accredited nursing degree, successful completion of the NCLEX-RN, and an active Iowa RN license or multistate compact privilege if eligible. Background checks, immunizations, CPR certification, and current clinical competence are also common requirements in Des Moines healthcare settings. Some facilities prefer experience in acute care, pediatrics, or med-surg, depending on the unit. If you are relocating to Iowa, it helps to confirm board rules and review current posting details before applying so your credentials line up with local hiring standards.
  • What are the main responsibilities of a registered nurse in an on-site hospital or clinic setting?

    Day-to-day work usually centers on patient assessment, medication administration, care planning, charting, and coordination with physicians, therapists, and support staff. In a Des Moines hospital or clinic, a registered nurse may also monitor vital signs, educate patients and families, prepare for procedures, and respond to changes in condition. The exact mix depends on the department, such as emergency, med-surg, oncology, or primary care. Because on-site care is hands-on, teamwork and quick judgment are essential, so it is useful to compare duties across facility types.
  • What skills and EHR experience do employers look for in a registered nurse?

    Employers in Des Moines usually value strong clinical judgment, clear communication, time management, and calm performance under pressure. Familiarity with electronic health records such as Epic, Cerner, Meditech, or similar systems is often important because charting accuracy affects both patient safety and compliance. Many teams also look for medication reconciliation, patient education, infection control, and care coordination skills. If you have used multiple EHR platforms or worked through a system transition, that can stand out. Reviewing postings can help you match your background to the tools each facility uses.
  • What shift schedules and work conditions can I expect in an on-site registered nurse role?

    Schedules often include 8-, 10-, or 12-hour shifts, with days, evenings, nights, weekends, and holidays depending on the unit. In Des Moines healthcare facilities, on-site work can mean fast-paced floors, standing for long periods, lifting or repositioning patients, and frequent interruptions. Some roles have rotating schedules, while others offer set shifts or self-scheduling. Overtime, on-call coverage, and higher differentials for nights or weekends are common in hospital settings. It is worth comparing departments to see which environment best fits your routine and energy level.
  • How does the hiring process usually work for registered nurse positions in Des Moines?

    The process typically starts with an online application, followed by resume review, phone screening, and one or more interviews with nurse managers or clinical leaders. Candidates may then complete skills validation, reference checks, background screening, and credential verification before an offer is made. In Des Moines, hospitals and clinics often move quickly for experienced nurses, especially in high-need units. Some employers also request license status, immunization records, and onboarding paperwork early in the process. Watching current listings can help you gauge timing and prepare for each step.
  • What career growth opportunities are available for a registered nurse in healthcare facilities?

    A registered nurse in Des Moines can move into charge nurse, preceptor, case management, quality improvement, or specialty leadership tracks after gaining experience. Many healthcare facilities also support advancement into ICU, emergency, perioperative, oncology, or outpatient specialties, often with added training and certification. Some nurses pursue BSN completion, MSN study, or nurse leadership roles such as clinical educator or unit manager. Because Iowa employers value both bedside skill and professional development, it helps to compare openings that mention tuition support, certification assistance, or internal promotion paths.

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131 jobs found

  • UnityPoint Health

    UnityPoint Health

    a day ago

    Rn acute -blank 4 pediatric oncology- blank children's hospital

    Overview Full-Time Nights 7pm-7:30am, weekend and holiday rotation Now Offering a Limited-Time $20,000 RN Sign-On Bonus! UnityPoint Health – Des Moines is offering a $20,000 sign-on bonus for...

    onsite, Des Moines, IA, United States
    Full TimeSenior (5+ years)
  • UnityPoint Health

    UnityPoint Health

    5 days ago

    Registered nurse residency (new grad)

    Overview Registered Nurse Residency- General Application Shift: Varied per department - Full Time Now Offering a Limited-Time $20,000 RN Sign-On Bonus! UnityPoint Health – Des Moines is offering a...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • Trinity Health

    Trinity Health

    5 days ago

    Clinic registered nurse (rn): primary care

    Employment Type: Full time Shift: Day Shift Description: At MercyOne, health care is more than just a doctor’s visit or a place to go when you’re in need of medical attention. Our Mission is based on...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • Fresenius Medical Care

    Fresenius Medical Care

    5 days ago

    Outpatient registered nurse - rn

    Outpatient Registered Nurse - RN SIGN ON BONUS AVAILABLE! PURPOSE AND SCOPE: The professional registered nurse Outpatient RN CAP 1 is an entry level designation into the Clinical Advancement Program...

    onsite, Des Moines, IA, United States
    Full TimeLead / Manager
  • Planned Parenthood North Central States

    Planned Parenthood North Central States

    5 days ago

    Per diem registered nurse (rn) - des moines, ia

    Per Diem Registered Nurse – Des Moines, IA Pay: The anticipated salary range for this position depending on experience and qualifications. Compensation is determined based on a variety of factors,...

    onsite, Des Moines, IA, United States
    Part TimeJunior (<2 years)
  • Compassus

    Compassus

    6 days ago

    Hospice registered nurse- prn rn

    Company: Compassus Position Summary The Hospice Registered Nurse is responsible for modeling the Compassus values of Compassion, Integrity, Excellence, Teamwork, and Innovation and for promoting the...

    onsite, Des Moines, IA, United States
    Part TimeEntry with Degree
  • UnityPoint Health

    UnityPoint Health

    7 days ago

    Registered nurse residency- younker 7 med/surg- methodist

    Overview Full Time Days or Nights, every 3rd weekend and holiday rotation Now Offering a Limited-Time $20,000 RN Sign-On Bonus! UnityPoint Health – Des Moines is offering a $20,000 sign-on bonus for...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • Fresenius Medical Care

    Fresenius Medical Care

    8 days ago

    New graduate registered nurse - rn

    PURPOSE AND SCOPE: This position is for graduates of an accredited school of Nursing working in a state that does not allow graduates to perform nursing duties until licensed. The specific job title...

    onsite, Algona, IA, United States
    Full TimeEntry with Degree
  • Cassia

    Cassia

    9 days ago

    Registered nurse rn 5000 bonus

    Valley View Village, a Cassia community, is hiring Registered Nurses (RN) to join our team! Staff enjoy a favorable staff-to-resident ratio which allows us to provide exceptional care and build...

    onsite, Des Moines, IA, United States
    $76k – $92k/yrFull TimeJunior (<2 years)
  • Anders Group

    Anders Group

    10 days ago

    Travel registered nurse cath lab tech - $3129/week

    Anders Group is hiring a Travel Cath Lab Tech Registered Nurse (RN) in Des Moines, IA Location: Des Moines, IA Start Date: 11/09/2026 Contract Length: 13 Weeks Shift: 4x10 Days Practice Area:...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • Veterans Health Administration

    Veterans Health Administration

    12 days ago

    Registered nurse- diabetes educator

    Summary The Diabetes Educator is a Registered Nurse (RN) responsible for providing competent, evidence-based diabetes education to staff and patients throughout the medical facility. The Diabetes...

    onsite, Des Moines, IA, United States
    $75k/yrFull TimeEntry with Degree
  • UnityPoint Health

    UnityPoint Health

    12 days ago

    Rn acute-powell 4 stroke/neuro/medical-methodist

    Overview Registered Nurse - Powell 4 - Stroke/Medical Neuro/Trauma - Methodist Now Offering a Limited-Time $20,000 RN Sign-On Bonus! UnityPoint Health – Des Moines is offering a $20,000 sign-on bonus...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • DaVita Kidney Care

    DaVita Kidney Care

    12 days ago

    Registered nurse

    Posting Date 10/16/2026 1201 Pennsylvania Ave, Des Moines, Iowa, 50316-2339, United States of America $10,000 BONUS LOCATED IN DES MOINES NO SUNDAY WORK NO NIGHTS DaVita is seeking a Registered Nurse...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • Select Specialty Hospital - Des Moines

    Select Specialty Hospital - Des Moines

    12 days ago

    Registered nurse (rn) - full-time new graduate

    Overview Position: New Graduate Registered Nurse (RN) Location: Des Moines, IA Schedule: Full-Time - New Graduate- Day & Night Available Sign-on bonus: $15,000 Select Specialty Hospital is a critical...

    onsite, Des Moines, IA, United States
    $15k/yrFull TimeEntry with Degree
  • Trinity Health

    Trinity Health

    13 days ago

    Pcu rn – progressive care registered nurse

    Employment Type: Full time Shift: 12 Hour Night Shift Description: RN Progressive Care Unit Nights New RN Rate Employment Type: Full Time - 36 hours per week Shift Schedule: Night Shift (7 PM - 7 AM)...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • UnityPoint Health

    UnityPoint Health

    14 days ago

    Rn acute- nicu - blank children's hospital

    Overview Full-Time Nights 7pm-7:30am, every fourth weekend and holiday rotation Now Offering a Limited-Time $20,000 RN Sign-On Bonus! UnityPoint Health – Des Moines is offering a $20,000 sign-on...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • Naphcare, Inc.

    Naphcare, Inc.

    15 days ago

    Registered nurse (rn)

    Overview NaphCare is hiring Registered Nurses (RNs) to join our team of medical professionals in Des Moines, Iowa where we manage all aspects of healthcare for the individuals who are currently...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • Select Specialty Hospital - Des Moines

    Select Specialty Hospital - Des Moines

    15 days ago

    Registered nurse (rn) - per diem

    Overview Position: Registered Nurse (RN) Location: Des Moines, IA Schedule: PRN / As Needed, Day & Night Shift, 12-Hour Shifts Compensation: $47.00 per hour plus competitive shift differentials for...

    onsite, Des Moines, IA, United States
    $95k/yrPart TimeJunior (<2 years)
  • UnityPoint Health

    UnityPoint Health

    15 days ago

    Registered nurse residency- medical/respiratory- methodist

    Overview Full Time Nights 7pm-7:30am, every 3rd weekend and holiday rotation Now Offering a Limited-Time $20,000 RN Sign-On Bonus! UnityPoint Health – Des Moines is offering a $20,000 sign-on bonus...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • UnityPoint Health

    UnityPoint Health

    16 days ago

    Registered nurse residency-3e med/surg-lutheran

    Overview Nurse Residency - 3 East Medical/Surgical - Lutheran Shifts: Full-time Nights, every 3rd weekend and holiday rotation Benefits Eligible Shift Differential for qualifying shifts Full Time...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • UnityPoint Health

    UnityPoint Health

    16 days ago

    Registered nurse residency-north 6

    Overview Full-Time Nights or Evenings, every third weekend and holiday rotation Now Offering a Limited-Time $20,000 RN Sign-On Bonus! UnityPoint Health – Des Moines is offering a $20,000 sign-on...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • Iowa Ortho

    Iowa Ortho

    19 days ago

    Operating room-registered nurse (rn)

    The Iowa Orthopedic Center, Surgery Center, a center of excellence, is currently searching for a skilled surgical RN who wants to work in a supportive, drama free environment and be a part of an...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • Trinity Health

    Trinity Health

    19 days ago

    Critical care rn educator nursing education

    Employment Type: Full time Shift: Day Shift Description: This Clinical Education Specialist will be supporting our Critical Care service line, Cardiac Surgical experience preferred. MercyOne Central...

    onsite, Des Moines, IA, United States
    Full TimeMiddle (2-4 years)
  • Trinity Health

    Trinity Health

    20 days ago

    Clinic registered nurse (rn): pulmonary & critical care

    Employment Type: Full time Shift: Day Shift Description: At MercyOne, health care is more than just a doctor’s visit or a place to go when you’re in need of medical attention. Our Mission is based on...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • Trinity Health

    Trinity Health

    20 days ago

    Clinic registered nurse (rn): palliative care

    Employment Type: Full time Shift: Day Shift Description: At MercyOne, health care is more than just a doctor’s visit or a place to go when you’re in need of medical attention. Our Mission is based on...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • UnityPoint Health

    UnityPoint Health

    20 days ago

    Rn acute-p5 surgical/neuro/ortho-methodist

    Overview Registered Nurse- Powell 5 Surgical Neuro/Trauma/Ortho - Methodist Now Offering a Limited-Time $20,000 RN Sign-On Bonus! UnityPoint Health – Des Moines is offering a $20,000 sign-on bonus...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • UnityPoint Health

    UnityPoint Health

    20 days ago

    Registered nurse residency-powell 5

    Overview Nurse Residency - Powell 5 Surgical Neuro/Trauma/Ortho - Methodist Now Offering a Limited-Time $20,000 RN Sign-On Bonus! UnityPoint Health – Des Moines is offering a $20,000 sign-on bonus...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • UnityPoint Health

    UnityPoint Health

    20 days ago

    Registered nurse residency-powell 4

    Overview Nurse Residency - Powell 4 - Stroke/Medical Neuro/Trauma - Methodist Now Offering a Limited-Time $20,000 RN Sign-On Bonus! UnityPoint Health – Des Moines is offering a $20,000 sign-on bonus...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • UnityPoint Health

    UnityPoint Health

    20 days ago

    Registered nurse residency-5e med/surg-lutheran

    Overview Registered Nurse Resident – 5 East Medical-Surgical Unit Location: Lutheran Shift: Fulltime Nights or Days Available + Weekend and Holiday Rotation $20K Sign on Bonus for full time positions...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • Trinity Health

    Trinity Health

    20 days ago

    Charge rn - neuro trauma

    Employment Type: Full time Shift: 12 Hour Day Shift Description: Apply today and ask about our Relocation and Sign On Bonus of up to $20,000!!! 0-1 years of experience: $10,000 1-3 years of...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • Trinity Health

    Trinity Health

    20 days ago

    Rn med surg

    Employment Type: Full time Shift: Day Shift Description: At MercyOne, health care is more than just a doctor’s visit or a place to go when you’re in need of medical attention. Our Mission is based on...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • UnityPoint Health

    UnityPoint Health

    23 days ago

    Rn acute-critical care internal resource team

    Overview UnityPoint Health – Des Moines is offering a $20,000 sign-on bonus for full-time eligible RNs (Including Residents) hired or offered into acute inpatient roles between through October 31,...

    onsite, Des Moines, IA, United States
    $40k/yrFull TimeJunior (<2 years)
  • UnityPoint Health

    UnityPoint Health

    24 days ago

    Registered nurse residency program - inpatient older adult mental health

    Overview Nurse Resident - Inpatient Older Adult Behavioral Health - Lutheran Shift: Full Time Nights 7:00pm-7:30am Shift differentials available for qualifying shifts Benefits Eligible Full Time...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • Veterans Health Administration

    Veterans Health Administration

    a month ago

    Registered nurse- medical surgical nurse manager

    Summary This position is eligible for the Education Debt Reduction Program (EDRP), a student loan payment reimbursement program. You must meet specific eligibility requirements per VHA policy and...

    onsite, Des Moines, IA, United States
    $80k/yrFull TimeMiddle (2-4 years)
  • Fresenius Medical Care

    Fresenius Medical Care

    a month ago

    Acute inpatient registered nurse - rn

    PURPOSE AND SCOPE: The professional registered nurse Inpatient Services RN CAP 1 is an entry level designation into the Clinical Advancement Program (CAP). This position is accountable and...

    onsite, Des Moines, IA, United States
    Full TimeLead / Manager
  • Concentra

    Concentra

    a month ago

    Registered nurse � full time

    Overview Schedule: Monday - Friday 6:30AM - 3:30PM! (Includes 1-hour lunch break) Are you ready to take your career to new heights? At Concentra, you will be a vital member of our patient care team...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • WesleyLife

    WesleyLife

    a month ago

    Registered nurse/licensed practical nurse (rn/lpn)

    Join WesleyLife and Help Revolutionize the Aging Experience! Job Duties: Registered Nurse or Licensed Practical Nurse Provide direct nursing care, such as wound care, IV therapy, and catheter...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • Trinity Health

    Trinity Health

    a month ago

    Clinic registered nurse (rn): neurology

    Employment Type: Full time Shift: Day Shift Description: At MercyOne, health care is more than just a doctor’s visit or a place to go when you’re in need of medical attention. Our Mission is based on...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • UnityPoint Health

    UnityPoint Health

    a month ago

    Registered nurse residency- younker 5 renal/uro/transplant- methodist

    Overview Full-Time Days or Nights, every third weekend and holiday rotation Now Offering a Limited-Time $20,000 RN Sign-On Bonus! UnityPoint Health – Des Moines is offering a $20,000 sign-on bonus...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)
  • UnityPoint Health

    UnityPoint Health

    a month ago

    Registered nurse residency- north 5 general surgery- methodist

    Overview Full-Time Days or Nights, every third weekend and holiday rotation Now Offering a Limited-Time $20,000 RN Sign-On Bonus! UnityPoint Health – Des Moines is offering a $20,000 sign-on bonus...

    onsite, Des Moines, IA, United States
    Full TimeJunior (<2 years)

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