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  1. Onsite Jobs
  2. South Dakota
  3. Sioux Falls
  4. Nurse Practitioner

Onsite Nurse Practitioner jobs in Sioux Falls, South Dakota, USA

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      Sarah Jenkins

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      Alex Chen

  • Mon
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      David G. (Hiring Manager)

    • 4:15 PM - 5:15 PM

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      Sophie L.

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      Marta W.

    • 2:30 PM - 3:00 PM

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      Daria (HR)

  • Wed
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      Qualifying Interview

      James Miller

    • 5:30 PM - 6:00 PM

      Discovery Interview

      Chris V.

  • Thu
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      Michael T.

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Nurse Practitioner Jobs in Sioux Falls, SD — On-Site Opportunities Await

Healthcare organizations across Sioux Falls are actively expanding their clinical teams, creating 136 open positions for skilled providers ready to deliver patient-centered care. This on-site role offers the chance to work directly within a thriving medical community, where demand for qualified nurse practitioner vacancies continues to rise. South Dakota's growing population and expanding healthcare infrastructure make this an exciting time to join the field.

Successful candidates bring strong clinical assessment skills, diagnostic expertise, and the ability to manage patient care plans independently. Employers seeking to hire a nurse practitioner value excellent communication, collaborative teamwork with physicians and support staff, and a compassionate approach to patient interactions. Familiarity with electronic health records, evidence-based practice guidelines, and current certification in advanced practice nursing remain essential for success in this demanding, rewarding profession.

On-site work remains the standard for nurse practitioner positions in Sioux Falls, given the hands-on nature of patient examinations, procedures, and direct collaboration with multidisciplinary teams. Local clinics, hospitals, and specialty practices report steady hiring momentum, reflecting South Dakota's broader push to strengthen primary and specialty care access. The regional healthcare market shows strong long-term stability, offering job security and clear pathways for career growth.

If you're ready to make a meaningful impact in patient care, now is the perfect time to explore nurse practitioner jobs in Sioux Falls. Global Work AI connects dedicated professionals with healthcare employers eager to welcome new talent. Discover your next opportunity and take the next step in your nursing career today.

Frequently Asked
Questions

Everything you need to know about
finding your next role
  • What is the average salary for a nurse practitioner in Sioux Falls?

    In Sioux Falls, pay for a nurse practitioner typically falls within a competitive Midwestern range, often around the low-to-mid $110,000s to about $140,000 annually, depending on specialty, years of experience, and employer type. Hospital systems, outpatient clinics, and specialty practices in South Dakota may also add shift differentials, productivity pay, or sign-on incentives. Benefits can materially affect total value, so it helps to compare base salary with retirement, health coverage, and paid leave when reviewing current listings.
  • What qualifications and nurse practitioner certifications are required for this role?

    Most employers in South Dakota expect an active RN license, a graduate degree in nursing practice, and national certification tied to the population focus, such as AANP or ANCC credentials. For a nurse practitioner role in Sioux Falls, applicants usually need eligibility for South Dakota APRN licensure, current DEA registration if prescribing controlled substances, and compliance with employer privileging rules. Some settings may prefer prior experience in primary care, family medicine, or acute care. Reviewing each posting carefully can clarify specialty-specific requirements.
  • What clinical skills are most important for an on-site nurse practitioner?

    Strong assessment and diagnostic reasoning sit at the center of success in an on-site nurse practitioner position. In Sioux Falls healthcare settings, employers also value medication management, preventive screening, chronic disease follow-up, and clear documentation in the electronic health record. Patient education, teamwork with physicians and nurses, and calm decision-making under time pressure are equally important. Comfort with triage and timely escalation of complex cases can set candidates apart, especially in busy clinics or hospital-linked practices. Comparing skills across local job ads can show which abilities are most in demand.
  • What are the main responsibilities of this nurse practitioner position in Sioux Falls?

    Day-to-day work often includes taking histories, performing physical exams, ordering and interpreting labs or imaging, diagnosing common conditions, and developing treatment plans. In Sioux Falls, a nurse practitioner may also manage follow-up visits, coordinate referrals, renew medications, and educate patients about lifestyle changes or home care. Depending on the employer, the role can involve population health goals, quality measures, and collaboration with physicians or specialists. The exact scope varies by department, so reviewing the care model in each listing is useful.
  • What is the hiring process for nurse practitioner jobs in South Dakota healthcare settings?

    Hiring usually starts with an application and credential review, followed by one or more interviews focused on clinical judgment, communication, and fit with the care team. In South Dakota healthcare settings, employers commonly verify RN licensure, APRN certification, references, and background checks before extending an offer. Some organizations may also request a case study, skills discussion, or shadow day. After selection, onboarding can include privileging, orientation, and EHR training. Checking current openings helps you see whether a facility moves quickly or uses a longer review cycle.
  • What patient population and care setting can I expect in this nurse practitioner role?

    The patient mix in Sioux Falls can vary widely by employer, but many nurse practitioner roles serve adults, older adults, or families in primary care, urgent care, specialty clinics, or hospital-affiliated practices. You may see preventive visits, ongoing management of diabetes, hypertension, respiratory issues, or post-discharge follow-up. Some sites focus on higher-acuity patients, while others emphasize routine outpatient care and continuity. The setting often shapes appointment length, case complexity, and collaboration style, so it is worth comparing listings to match your experience and preferred pace.
  • What career growth opportunities are available for nurse practitioners in South Dakota?

    South Dakota offers several paths for advancement, especially for a nurse practitioner who wants to build expertise in a specialty, step into lead-provider responsibilities, or move into management. In Sioux Falls, opportunities may include transitioning from general practice into cardiology, pediatrics, women’s health, behavioral health, or acute care. Some professionals later pursue teaching, quality improvement, or administrative roles, and continuing education can support that shift. Expanding certifications or gaining experience with complex patient panels can open doors, so it helps to track postings for emerging specialties and leadership tracks.

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136 jobs found

  • Interim HealthCare - Sioux Falls, SD

    Interim HealthCare - Sioux Falls, SD

    Today

    Licensed practical nurse (lpn)

    Who we are: Interim HealthCare is America's leading provider of home care and healthcare staffing. As a family owned, women owned, and veteran owned business, we have been in Sioux Falls the past 34+...

    onsite, Brookings, SD, United States
    $81k – $85k/yrPart TimeJunior (<2 years)
  • BAART Programs

    BAART Programs

    Today

    Dispensing nurse (lpn)

    Part Time Dispensing Nurse – LPN BAART Programs is looking for a detail oriented and empathetic Licensed Practical Nurse to dispense prescribed medications as part of a treatment team in partnership...

    onsite, Sioux Falls, SD, United States
    Part TimeJunior (<2 years)
  • Avera Health

    Avera Health

    Today

    Registered nurse (rn) or licensed practical nurse (lpn) | 69th and western clinic

    Location: Avera 69th & Western Clinic Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent upon...

    onsite, Sioux Falls, SD, United States
    $45k – $83k/yrFull TimeJunior (<2 years)
  • ADVANCED CORRECTIONAL HEALTHCARE

    ADVANCED CORRECTIONAL HEALTHCARE

    2 days ago

    Registered nurse - prn $45-$47/hr

    Job Details: Job Location: Minnehaha County Juvenile Detention Center - Sioux Falls, SD Position Type: PRN Education Level: 2 Year Degree Salary Range: $45.00 - $47.00 Hourly Travel Percentage:...

    onsite, Sioux Falls, SD, United States
    $91k – $95k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    2 days ago

    Registered nurse (rn) | endocrinology clinic

    Location: Avera Endocrinology & Diabetes Sioux Falls Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate...

    onsite, Sioux Falls, SD, United States
    $56k – $83k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    3 days ago

    Registered nurse (rn) - new grad - august 2027

    Location: Avera McKennan Hospital Worker Type: Regular Work Shift: Rotating days/evenings/nights/weekends/holidays (United States of America) Pay Range: The pay range for this position is listed...

    onsite, Sioux Falls, SD, United States
    $66k – $98k/yrFull TimeEntry with Degree
  • Avera Health

    Avera Health

    3 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) | hematology & bone marrow transplant clinic

    Location: Hematology, Transplant and Cellular Therapy Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate...

    onsite, Sioux Falls, SD, United States
    $45k – $83k/yrFull TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    6 days ago

    Rn - registered nurse - pre-experience and recovery care - pre op office - prn

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $65k – $97k/yrPart TimeJunior (<2 years)
  • State of South Dakota

    State of South Dakota

    6 days ago

    Nurse supervisor (sdsp)

    PLEASE ATTACH THE ADDITIONAL REQUIREMENTS LISTED AT THE BOTTOM OF THIS PAGE Job ID: 37311 Agency: Department of Corrections - Clinical Services Location: Sioux Falls, SD - SDSP Salary: $40.00 to...

    onsite, Sioux Falls, SD, United States
    $81k – $101k/yrFull TimeLead / Manager
  • Sanford Health

    Sanford Health

    7 days ago

    App - nurse practitioner or physician assistant | interventional radiology

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    Full TimeJunior (<2 years)
  • One to One Health

    One to One Health

    7 days ago

    Nurse practitioner

    Job Details Job Location: Sioux Falls, SD Position Type: Full Time Salary Range: $140000.00 - $170000.00 Job Shift: Any Job Category: Health Care About One to One Health At One to One Health, we're...

    onsite, Sioux Falls, SD, United States
    $140k – $170k/yrFull TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    7 days ago

    Rn - registered nurse - pre-experience and recovery care - prn

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $65k – $97k/yrPart TimeJunior (<2 years)
  • Avera Health

    Avera Health

    8 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) | clinic

    Location: Avera Internal Medicine Cliff Ave Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent...

    onsite, Sioux Falls, SD, United States
    $45k – $83k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    9 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) | gastroenterology clinic | prn

    Location: Avera Gastroenterology Sioux Falls Worker Type: PRN Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent...

    onsite, Sioux Falls, SD, United States
    $45k – $83k/yrPart TimeJunior (<2 years)
  • Avera Health

    Avera Health

    10 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) or medical assistant | dermatology clinic

    Location: Avera Dermatology Minnesota Ave Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent...

    onsite, Sioux Falls, SD, United States
    $40k – $83k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    10 days ago

    Registered nurse (rn) | psychiatry clinic | prn

    Location: Avera Behavioral Health Sioux Falls Worker Type: PRN Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent...

    onsite, Sioux Falls, SD, United States
    $56k – $83k/yrFull TimeJunior (<2 years)
  • Interim HealthCare - Sioux Falls, SD

    Interim HealthCare - Sioux Falls, SD

    10 days ago

    Registered nurse - pediatrics

    Registered Nurse - Pediatrics $40–$44 Per Hour | Paid Weekly | Flexible Schedule Who We Are Interim HealthCare is a leading provider of home care and healthcare staffing services across America. As a...

    onsite, Sioux Falls, SD, United States
    $81k – $89k/yrPart TimeJunior (<2 years)
  • Interim HealthCare - Sioux Falls, SD

    Interim HealthCare - Sioux Falls, SD

    10 days ago

    Licensed practical nurse - pediatrics

    Licensed Practical Nurse - Pediatrics $34-36 Per Hour | Paid Weekly | Flexible Shifts Who We Are Interim HealthCare is a leading provider of home care and healthcare staffing services across America....

    onsite, Sioux Falls, SD, United States
    $69k – $73k/yrPart TimeJunior (<2 years)
  • Avera Health

    Avera Health

    10 days ago

    Nurse practitioner or physician assistant | neurology | inpatient

    Nurse Practitioner or Physician Assistant | Neurology | Inpatient Location: Avera Medical Group Neurosurgery-Sioux Falls Worker Type: Regular Work Shift: Day/Evening/Weekend/Holiday Shift (United...

    onsite, Sioux Falls, SD, United States
    Full TimeJunior (<2 years)
  • Dow Rummel Village

    Dow Rummel Village

    11 days ago

    Overnight nurse supervisor

    Assisted Living Overnight Nurse Supervisor Full-Time | Salaried | Monday - Thursday 6:00 p.m. - 4:00 a.m. rotating every 5th weekend Pay Range: $35.50 - $56.21 Relocation Assistance Available Who We...

    onsite, Sioux Falls, SD, United States
    $40k/yrFull TimeLead / Manager
  • Sanford Health

    Sanford Health

    15 days ago

    Licensed practical nurse - lpn - orthopedics & sports medicine

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $44k – $59k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    15 days ago

    Registered nurse (rn) | palliative medicine plaza 4

    Location: Avera Palliative Medicine Sioux Falls Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate...

    onsite, Sioux Falls, SD, United States
    $56k – $83k/yrFull TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    17 days ago

    Lpn - licensed practical nurse - ma - medical assistant - pct - patient care tech - post acute care - ft days

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $33k – $59k/yrFull TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    17 days ago

    Lpn - licensed practical nurse - acute care - ft

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $44k – $59k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    17 days ago

    Registered nurse (rn) | pre anesthesia call center

    Location: Avera McKennan Hospital Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent upon...

    onsite, Sioux Falls, SD, United States
    $56k – $83k/yrPart TimeJunior (<2 years)
  • Avera Health

    Avera Health

    17 days ago

    Registered nurse (rn) or licensed practical nurse or medical assistant | plastic surgery clinic

    Location: Avera Plastic & Reconstructive Surgery Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate...

    onsite, Sioux Falls, SD, United States
    $45k – $83k/yrFull TimeJunior (<2 years)
  • Cherokee Federal

    Cherokee Federal

    19 days ago

    Nurse practitioner, aprn, fnp

    A government contract requires that this position be restricted to U.S. citizens. This position requires a Common Access Card (CAC), and the ability to pass the U.S. Department of Defense (DoD)...

    onsite, Fargo, ND, United States
    $120k – $130k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    20 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) | behavioral health child unit

    Location: Avera Behavioral Health Center-Sioux Falls Worker Type: Regular Work Shift: Night Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay...

    onsite, Sioux Falls, SD, United States
    $49k – $98k/yrFull TimeMiddle (2-4 years)
  • Sanford Health

    Sanford Health

    21 days ago

    Lpn - licensed practical nurse - diabetes & thyroid clinic - ft days

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $44k – $59k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    21 days ago

    Licensed practical nurse (lpn) | discharge lounge

    Location: Avera McKennan Hospital Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent upon...

    onsite, Sioux Falls, SD, United States
    $49k – $68k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    22 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) or medical assistant | obgyn

    Location: Avera Obstetrics & Gynecology Plaza 1 Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate...

    onsite, Sioux Falls, SD, United States
    $40k – $83k/yrFull TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    22 days ago

    Lpn - licensed practical nurse or ma - medical assistant - diabetes & thyroid clinic - ft days

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $38k – $58k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    23 days ago

    Registered nurse (rn) | breast health clinic

    Location: Avera Cancer Institute-Sioux Falls Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate...

    onsite, Sioux Falls, SD, United States
    $56k – $83k/yrFull TimeEntry with Degree
  • Avera Health

    Avera Health

    24 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) | dawley farm pediatrics

    Location: Avera Family Medicine Center Dawley Farm Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate...

    onsite, Sioux Falls, SD, United States
    $45k – $83k/yrFull TimeJunior (<2 years)
  • Smithfield Foods

    Smithfield Foods

    a month ago

    Nurse (lpn)

    If you are currently employed at Smithfield, please log into Workday and submit your application through the Jobs Hub. Have a seat at our table. When you join Smithfield, you become part of something...

    onsite, Sioux Falls, SD, United States
    Full TimeJunior (<2 years)
  • Avera Health

    Avera Health

    a month ago

    Registered nurse (rn) or licensed practical nurse (lpn) | transitional care unit

    Location: Avera Prince of Peace-Transitional Care Worker Type: Regular Work Shift: Day/Evening/Weekend/Holiday Shift (United States of America) Pay Range: The pay range for this position is listed...

    onsite, Sioux Falls, SD, United States
    $49k – $98k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    a month ago

    Registered nurse (rn) or licensed practical nurse (lpn) | specialty clinic float

    Location: Plaza 4-Sioux Falls Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent upon...

    onsite, Sioux Falls, SD, United States
    $45k – $64k/yrFull TimeJunior (<2 years)
  • Veterans Health Administration

    Veterans Health Administration

    a month ago

    Registered nurse - associate chief of nursing

    Summary Join the Sioux Falls VA Health Care System as Chief Nurse for Primary and Specialty Medicine Outpatient Integrated Clinical Communities. Lead nursing operations across primary care, specialty...

    onsite, Sioux Falls, SD, United States
    $131k/yrFull TimeDirector
  • Limitless Male

    Limitless Male

    a month ago

    Registered nurse or licensed practical nurse

    About Limitless Male Medical Limitless Male Medical Clinic is a leader in men’s health optimization, focused on helping patients look, feel, and perform at their best. Through personalized care,...

    onsite, Sioux Falls, SD, United States
    Full TimeEntry with Degree
  • Avera Health

    Avera Health

    a month ago

    Registered nurse (rn) navigator | dialysis

    Location: Avera Dialysis-Sioux Falls Worker Type: Regular Work Shift: Primarily days with possible weekends/evenings/holidays (United States of America) Pay Range: The pay range for this position is...

    onsite, Sioux Falls, SD, United States
    $66k – $98k/yrFull TimeJunior (<2 years)

10,000,000+ more jobs available!