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  2. South Dakota
  3. Nurse Practitioner

Onsite Nurse Practitioner jobs in South Dakota, USA

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Nurse Practitioner On-Site Jobs — Discover Opportunities in South Dakota

Across South Dakota, healthcare providers are actively expanding their teams, fueling consistent demand for nurse practitioner on-site jobs throughout the state. With 254 open positions currently available, clinics and hospitals are looking for skilled professionals ready to deliver hands-on, patient-centered care. This growth mirrors a nationwide shift toward stronger primary and specialty care access in both rural and urban communities.

Success in this role calls for strong clinical judgment, excellent communication, and the ability to manage diverse patient needs independently. Employers typically look for candidates with solid diagnostic skills, proficiency in electronic health records, and a collaborative mindset that supports interdisciplinary teamwork. Compassion, adaptability, and a commitment to continuous learning remain essential traits for anyone pursuing nurse practitioner positions in today's evolving healthcare landscape.

On-site nurse practitioner roles in South Dakota typically involve direct, in-person engagement with patients across clinics, hospitals, and community health centers. The state's growing population and limited access to specialists in rural areas continue to fuel a strong hiring outlook for advanced practice providers. Facilities are eager to hire a nurse practitioner who can deliver consistent, high-quality care within established local healthcare networks.

If you're ready to advance your career while making a meaningful impact, now is the perfect time to explore nurse practitioner vacancies across South Dakota. Global Work AI connects passionate clinicians with employers eager to welcome new talent, making it easier than ever to find the right opportunity and take the next step forward.

Frequently Asked
Questions

Everything you need to know about
finding your next role
  • What is the average nurse practitioner salary in South Dakota?

    Pay for a nurse practitioner in South Dakota commonly falls around the low-to-mid $120,000s per year, though actual offers vary by specialty, years of experience, and whether the role is in a rural clinic, specialty practice, or hospital system. On-site positions in larger medical centers may include shift differentials, call pay, or bonus structures that raise total compensation. National and local market data both show strong demand in the state, so it helps to compare base pay, benefits, and productivity expectations when reviewing current listings.
  • What qualifications and nurse practitioner certification are required in the USA?

    In the USA, employers typically expect an active RN license, an accredited graduate degree in advanced practice nursing, and national certification in a population focus such as family, adult-gerontology, pediatrics, or acute care. Most South Dakota employers also require state APRN licensure and prescriptive authority where applicable. Clinical hours during training, BLS or ACLS depending on setting, and clean background and credentialing records are standard. Because requirements can differ by specialty and facility, it is smart to check the specific posting before applying.
  • What are the main responsibilities of a nurse practitioner in an on-site clinic or hospital setting?

    Day-to-day work usually includes evaluating patients, taking histories, ordering and interpreting diagnostic tests, diagnosing common and complex conditions, and creating treatment plans. In an on-site clinic or hospital setting, a nurse practitioner may also prescribe medications, coordinate with physicians and nurses, manage follow-up care, and educate patients about prevention and self-management. South Dakota facilities often rely on advanced practice providers to support access to care in both urban and rural areas, so scope and patient mix can vary by department.
  • What skills do employers look for in a nurse practitioner?

    Strong clinical judgment is only part of the picture. Employers in South Dakota also value clear communication, teamwork, charting accuracy, comfort with electronic health records, and the ability to stay organized in a fast-moving on-site environment. Patient education, empathy, adaptability, and confidence with independent decision-making are important as well. In hospital-based roles, prioritizing cases and responding calmly under pressure matters. Reviewing current nurse practitioner job descriptions can help you match your strengths to the skills each employer emphasizes most.
  • How does the hiring process typically work for an on-site nurse practitioner role in South Dakota?

    The process often starts with an application review, followed by a recruiter or manager screening call and one or more interviews with clinical leaders. After that, employers usually verify licensure, certification, education, references, and work history before moving to credentialing and a formal offer. In South Dakota, hospital systems and larger group practices may also require onboarding paperwork, background checks, drug screening, and sometimes privileging review. Timelines can differ, so comparing several openings can give you a realistic sense of pace.
  • What work schedule and patient flow can I expect in an on-site nurse practitioner job?

    Schedules depend on the setting, but many on-site roles follow weekday clinic hours, while hospital positions may include rotating shifts, weekends, evenings, or call coverage. Patient flow can range from steady scheduled visits in primary care to faster-paced same-day or inpatient encounters in acute care. In South Dakota, some facilities serve broad geographic regions, which can affect appointment length and caseload. Ask about visit volumes, support staff, and documentation expectations so you can gauge workload before moving ahead.
  • What career growth opportunities are available for a nurse practitioner in South Dakota?

    Career paths can expand into specialty care, leadership, education, quality improvement, or service-line management, especially within larger health systems. Many nurse practitioners in South Dakota also move into rural health, telehealth support, or higher-acuity roles after gaining experience. Additional certification in areas like acute care, psychiatry, or women’s health can open more options and improve earning potential. If you are planning long term, it is useful to compare specialty openings and look for employers that support continuing education and advancement.

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254 jobs found

  • Peaceful Pines Senior Living - Spearfish

    Peaceful Pines Senior Living - Spearfish

    Today

    Registered nurse (rn)

    The Registered Nurse (RN) plays a critical role in supporting the health, well-being, and quality of life of residents across Assisted Living and Memory Care. This position is responsible for...

    onsite, Spearfish, SD, United States
    Full TimeJunior (<2 years)
  • Community HealthCare Association of the Dakotas

    Community HealthCare Association of the Dakotas

    Today

    Nurse practitioner or physician assistant

    Benefits: 401(k) matching Competitive salary Dental insurance Health insurance Vision insurance Horizon Health in Wessington Springs, SD is seeking two full-time Nurse Practitioner or Physician...

    onsite, Wessington Springs, SD, United States
    Full TimeJunior (<2 years)
  • Avera Health

    Avera Health

    Today

    Registered nurse (rn) or licensed practical nurse (lpn) | 69th and western clinic

    Location: Avera 69th & Western Clinic Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent upon...

    onsite, Sioux Falls, SD, United States
    $45k – $83k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    2 days ago

    Nurse practitioner or physician assistant | hospitalist

    Location: Avera Sacred Heart Hospital Worker Type: Regular Work Shift: Day Shift (United States of America) Position Highlights You Belong at Avera Be part of a multidisciplinary team built with...

    onsite, Yankton, SD, United States
    Full TimeJunior (<2 years)
  • ADVANCED CORRECTIONAL HEALTHCARE

    ADVANCED CORRECTIONAL HEALTHCARE

    2 days ago

    Registered nurse - prn $45-$47/hr

    Job Details: Job Location: Minnehaha County Juvenile Detention Center - Sioux Falls, SD Position Type: PRN Education Level: 2 Year Degree Salary Range: $45.00 - $47.00 Hourly Travel Percentage:...

    onsite, Sioux Falls, SD, United States
    $91k – $95k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    2 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) | long term care

    Location: Avera Majestic Bluffs/Avera Sister James Care Center Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual...

    onsite, Yankton, SD, United States
    $49k – $98k/yrFull TimeJunior (<2 years)
  • Limitless Male

    Limitless Male

    2 days ago

    Prn- certified medical assistant or licensed practical nurse or registered nurse

    JOB TITLE: Medical Support Specialist- RN/ LPN/ MA - PRN EMPLOYER: Limitless Male Medical DEPARTMENT: Medical Operations REPORTS TO: Operations Manager About Limitless Male Medical Limitless Male...

    onsite, Dakota Dunes, SD, United States
    Full TimeJunior (<2 years)
  • Avera Health

    Avera Health

    2 days ago

    Registered nurse (rn) | endocrinology clinic

    Location: Avera Endocrinology & Diabetes Sioux Falls Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate...

    onsite, Sioux Falls, SD, United States
    $56k – $83k/yrFull TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    3 days ago

    Lpn / licensed practical nurse - ft days

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, De Smet, SD, United States
    $53k – $73k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    3 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) | hematology & bone marrow transplant clinic

    Location: Hematology, Transplant and Cellular Therapy Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate...

    onsite, Sioux Falls, SD, United States
    $45k – $83k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    6 days ago

    Registered nurse (rn) | pre-post operative

    Location: Avera Sacred Heart Hospital Worker Type: Regular Work Shift: Primarily days with night, weekend and holiday on-call involvement (United States of America) Pay Range: The pay range for this...

    onsite, Yankton, SD, United States
    $66k – $98k/yrPart TimeJunior (<2 years)
  • Horizon Health

    Horizon Health

    6 days ago

    Nurse practitioner or physician assistant

    Benefits: Student Loan Repayment and Forgiveness Programs 10.5 Paid Holidays Sick Time Vacation Time Disability and Life Insurance Employee Assistance Program AFLAC Medical, Dental, and Behavioral...

    onsite, Wessington Springs, SD, United States
    Full TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    6 days ago

    Rn - registered nurse - pre-experience and recovery care - pre op office - prn

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $65k – $97k/yrPart TimeJunior (<2 years)
  • State of South Dakota

    State of South Dakota

    6 days ago

    Psychiatric mental health nurse practitioner

    PLEASE ATTACH THE ADDITIONAL REQUIREMENTS LISTED AT THE BOTTOM OF THIS PAGE JOB ID: 37612 Agency: Department of Corrections – Clinical Services Location: Pierre, SD Salary: $114,318.00 to $130,000.00...

    onsite, Pierre, SD, United States
    $114k – $130k/yrFull TimeJunior (<2 years)
  • State of South Dakota

    State of South Dakota

    6 days ago

    Nurse supervisor (sdsp)

    PLEASE ATTACH THE ADDITIONAL REQUIREMENTS LISTED AT THE BOTTOM OF THIS PAGE Job ID: 37311 Agency: Department of Corrections - Clinical Services Location: Sioux Falls, SD - SDSP Salary: $40.00 to...

    onsite, Sioux Falls, SD, United States
    $81k – $101k/yrFull TimeLead / Manager
  • Sanford Health

    Sanford Health

    7 days ago

    App - nurse practitioner or physician assistant | interventional radiology

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    Full TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    7 days ago

    Rn - registered nurse - pre-experience and recovery care - prn

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $65k – $97k/yrPart TimeJunior (<2 years)
  • Avera Health

    Avera Health

    8 days ago

    Physician assistant or nurse practition | family medicine

    Location: Avera Family Medicine Yankton Worker Type: Regular Work Shift: Day Shift (United States of America) Position Highlights You Belong at Avera Be part of a multidisciplinary team built with...

    onsite, Yankton, SD, United States
    Full TimeJunior (<2 years)
  • Avera Health

    Avera Health

    8 days ago

    Registered nurse (rn) or licensed practical nurse (lpn or medical assistant | pediatric clinic

    Location: Avera Pediatrics Mitchell Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent upon...

    onsite, Mitchell, SD, United States
    $40k – $83k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    8 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) |long term care | prn

    Location: Avera St Benedict Nursing Home Worker Type: PRN Work Shift: Rotating days/evenings/nights/weekends (United States of America) Pay Range: The pay range for this position is listed below....

    onsite, Parkston, SD, United States
    $66k – $98k/yrPart TimeJunior (<2 years)
  • Avera Health

    Avera Health

    9 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) | gastroenterology clinic | prn

    Location: Avera Gastroenterology Sioux Falls Worker Type: PRN Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent...

    onsite, Sioux Falls, SD, United States
    $45k – $83k/yrPart TimeJunior (<2 years)
  • Avera Health

    Avera Health

    9 days ago

    Registered nurse (rn) | prn

    Location: Tyndall, SD Worker Type: PRN Work Shift: As Needed (United States of America) St. Michael’s Hospital Avera is looking for individuals to join our positive and team-oriented organization. We...

    onsite, Tyndall, SD, United States
    Full TimeJunior (<2 years)
  • Fidelity Partners

    Fidelity Partners

    9 days ago

    Nurse practitioner

    Nurse Practitioner Boxelder Job Corps Civilian Conservation Center - Nemo, South Dakota This Position Is Contingent Upon Contract Award Position Details Customer: USDA Forest Service, Job Corps...

    onsite, Nemo, SD, United States
    $141k/yrPart TimeJunior (<2 years)
  • Avera Health

    Avera Health

    10 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) or medical assistant | dermatology clinic

    Location: Avera Dermatology Minnesota Ave Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent...

    onsite, Sioux Falls, SD, United States
    $40k – $83k/yrFull TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    10 days ago

    App - nurse practitioner or physician assistant | pame clinic

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Rapid City, SD, United States
    Part TimeEntry with Degree
  • Avera Health

    Avera Health

    10 days ago

    Registered nurse (rn) | psychiatry clinic | prn

    Location: Avera Behavioral Health Sioux Falls Worker Type: PRN Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent...

    onsite, Sioux Falls, SD, United States
    $56k – $83k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    10 days ago

    Nurse practitioner or physician assistant | neurology | inpatient

    Nurse Practitioner or Physician Assistant | Neurology | Inpatient Location: Avera Medical Group Neurosurgery-Sioux Falls Worker Type: Regular Work Shift: Day/Evening/Weekend/Holiday Shift (United...

    onsite, Sioux Falls, SD, United States
    Full TimeJunior (<2 years)
  • Akicita Federal, LLC

    Akicita Federal, LLC

    13 days ago

    Certified nurse midwife

    Akicita Federal is hiring Certified Nurse-Midwives (CNMs) to provide full-scope obstetric and gynecological care at Rosebud IHS Hospital in Rosebud, South Dakota, serving American Indian and Alaska...

    onsite, Rosebud, SD, United States
    $229k – $235k/yrFull TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    15 days ago

    Licensed practical nurse - lpn - orthopedics & sports medicine

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $44k – $59k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    17 days ago

    Registered nurse (rn) or licensed practical nurse or medical assistant | plastic surgery clinic

    Location: Avera Plastic & Reconstructive Surgery Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate...

    onsite, Sioux Falls, SD, United States
    $45k – $83k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    22 days ago

    Nurse practitioner or physician assistant | emergency medicine

    Location: Avera Sacred Heart Hospital Worker Type: Regular Work Shift: Day Shift (United States of America) Position Highlights You Belong at Avera Be part of a multidisciplinary team built with...

    onsite, Yankton, SD, United States
    Part TimeJunior (<2 years)
  • Avera Health

    Avera Health

    22 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) or medical assistant | obgyn

    Location: Avera Obstetrics & Gynecology Plaza 1 Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate...

    onsite, Sioux Falls, SD, United States
    $40k – $83k/yrFull TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    22 days ago

    Lpn - licensed practical nurse - urgent care

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Rapid City, SD, United States
    $44k – $59k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    23 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) or medical assistant | harrisburg clinic

    Location: Avera Harrisburg Clinic Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent upon...

    onsite, Harrisburg, SD, United States
    $40k – $83k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    24 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) | dawley farm pediatrics

    Location: Avera Family Medicine Center Dawley Farm Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate...

    onsite, Sioux Falls, SD, United States
    $45k – $83k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    a month ago

    Registered nurse (rn) or licensed practical nurse (lpn) | transitional care unit

    Location: Avera Prince of Peace-Transitional Care Worker Type: Regular Work Shift: Day/Evening/Weekend/Holiday Shift (United States of America) Pay Range: The pay range for this position is listed...

    onsite, Sioux Falls, SD, United States
    $49k – $98k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    a month ago

    Registered nurse (rn) or licensed practical nurse (lpn) | specialty clinic float

    Location: Plaza 4-Sioux Falls Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent upon...

    onsite, Sioux Falls, SD, United States
    $45k – $64k/yrFull TimeJunior (<2 years)
  • Veterans Health Administration

    Veterans Health Administration

    a month ago

    Registered nurse - associate chief of nursing

    Summary Join the Sioux Falls VA Health Care System as Chief Nurse for Primary and Specialty Medicine Outpatient Integrated Clinical Communities. Lead nursing operations across primary care, specialty...

    onsite, Sioux Falls, SD, United States
    $131k/yrFull TimeDirector
  • Limitless Male

    Limitless Male

    a month ago

    Registered nurse or licensed practical nurse

    About Limitless Male Medical Limitless Male Medical Clinic is a leader in men’s health optimization, focused on helping patients look, feel, and perform at their best. Through personalized care,...

    onsite, Sioux Falls, SD, United States
    Full TimeEntry with Degree
  • Avera Health

    Avera Health

    a month ago

    Registered nurse (rn) navigator | dialysis

    Location: Avera Dialysis-Sioux Falls Worker Type: Regular Work Shift: Primarily days with possible weekends/evenings/holidays (United States of America) Pay Range: The pay range for this position is...

    onsite, Sioux Falls, SD, United States
    $66k – $98k/yrFull TimeJunior (<2 years)

10,000,000+ more jobs available!