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  2. South Carolina
  3. Charleston
  4. Nurse Practitioner

Onsite Nurse Practitioner jobs in Charleston, South Carolina, USA

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      Alex Chen

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      Marta W.

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Nurse Practitioner Jobs in Charleston, SC — On-Site Opportunities Await

Charleston's healthcare network continues to expand, creating steady demand for nurse practitioner jobs in Charleston. With 155 open positions available, this on-site role offers the chance to work directly within a thriving clinical community. Employers across the region are actively looking to hire a nurse practitioner who can deliver high-quality, patient-centered care in a fast-paced environment.

Success in this profession relies on strong clinical judgment, excellent communication skills, and the ability to manage diverse patient needs independently. Employers typically seek candidates with a valid APRN license, board certification, and hands-on experience in diagnosis, treatment planning, and preventive care. Compassion, attention to detail, and comfort working within interdisciplinary teams remain essential traits for anyone pursuing nurse practitioner positions in today's competitive healthcare market.

On-site work for nurse practitioners in Charleston typically involves close collaboration with physicians, specialists, and administrative staff within hospitals or private practices. The city's growing population and expanding medical facilities continue to fuel strong regional demand, making it an attractive market for professionals seeking long-term career growth. Local clinics and hospital systems increasingly value providers who can build lasting patient relationships through consistent, in-person engagement.

If you're ready to take the next step in your healthcare career, explore current nurse practitioner vacancies through Global Work AI. Our platform connects dedicated professionals with employers eager to welcome new talent to their teams. Discover an opportunity that matches your skills and start making a meaningful difference in patient care today.

Frequently Asked
Questions

Everything you need to know about
finding your next role
  • What is the average nurse practitioner salary in Charleston?

    In Charleston, compensation for a nurse practitioner commonly lands in the low-to-mid six figures, with many employers offering roughly $110,000 to $130,000 a year, depending on specialty, experience, and patient volume. On-site roles in South Carolina may also include bonus pay, shift differentials, or productivity incentives, especially in hospital and urgent care settings. Salaries can vary by clinic type, years in advanced practice, and whether the position requires procedures or call coverage. Reviewing current Charleston listings can help you compare pay with benefits and workload.
  • What qualifications are required to become a nurse practitioner in South Carolina?

    A strong clinical foundation is essential before stepping into an advanced practice role in South Carolina. Most employers expect an active registered nurse license, completion of a Master of Science in Nursing or Doctor of Nursing Practice program, and formal nurse practitioner preparation in a population focus such as family, adult-gerontology, pediatrics, or women’s health. Accredited graduate education, supervised clinical hours, and passing a national board exam are standard requirements. In Charleston, hiring managers often look for graduates who are ready for direct patient care, so it helps to compare local openings with your training background.
  • What certifications and state licensure are needed for a nurse practitioner job in South Carolina?

    To work as a nurse practitioner in South Carolina, you generally need an active South Carolina RN license plus advanced practice authorization through the state board. National certification from a recognized body, such as AANP or ANCC, is typically required for your specialty area, and prescriptive authority may involve additional state steps. Employers in Charleston may also expect current BLS and sometimes ACLS, depending on the setting. Because rules can change, it is wise to verify both certification status and board requirements before applying to local nurse practitioner positions.
  • What are the main responsibilities of a nurse practitioner working on-site in Charleston?

    Day-to-day duties usually center on evaluating patients, ordering and interpreting tests, developing treatment plans, prescribing medications, and tracking progress over time. In Charleston, an on-site nurse practitioner may also handle preventive care, chronic disease management, same-day visits, and coordination with physicians, nurses, and specialists. In hospital-based or specialty settings, responsibilities can include procedures, discharge planning, or follow-up after acute episodes. The exact workload depends on the employer, so it is useful to compare clinic, urgent care, and inpatient job descriptions before deciding which environment fits best.
  • What clinical skills and experience do employers look for when hiring a nurse practitioner?

    Employers usually want solid assessment skills, strong diagnostic judgment, and confidence managing common acute and chronic conditions. For nurse practitioner roles in Charleston, experience with electronic health records, evidence-based treatment plans, medication management, and patient education is often important. Many hiring teams also value prior work in primary care, urgent care, emergency medicine, or a relevant specialty, plus the ability to work independently while staying aligned with physician oversight and team protocols. Communication, triage, and time management matter too, especially in busy on-site practices where patient flow can be demanding.
  • What is the hiring process like for a nurse practitioner position in Charleston?

    The process often starts with an online application and resume review, followed by a recruiter screen or phone interview. After that, Charleston employers may schedule interviews with clinical leaders, request proof of licensure and certification, and check references, background history, or credentials. Some organizations also include a case discussion or scenario-based questions to gauge clinical judgment. For on-site nurse practitioner roles, candidates may meet the team in person and tour the facility before an offer is made. Comparing several local openings can give you a clearer sense of pace, timeline, and expectations.
  • What shift schedules and on-call expectations are typical for on-site nurse practitioner jobs in Charleston?

    Schedules vary by setting, but many on-site nurse practitioner jobs in Charleston follow weekday daytime hours, especially in primary care and outpatient clinics. Hospital, urgent care, and specialty practices may use evenings, weekends, rotating shifts, or extended coverage. On-call duties are more common in inpatient or surgical environments, where providers may need to respond to urgent questions or patient changes after hours. The amount of call can differ a lot by employer, so it is smart to compare staffing models, rotation frequency, and overtime policies when reviewing job postings.

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155 jobs found

  • Medical University of South Carolina

    Medical University of South Carolina

    Today

    Forensic nurse examiner - art ed

    Job Description Summary Under general supervision, the Forensic Nurse Examiner provides individualized, goal-directed patient care to families and patients at the competent level utilizing the...

    onsite, Charleston, SC, United States
    Full TimeSenior (5+ years)
  • Roper St. Francis Healthcare

    Roper St. Francis Healthcare

    2 days ago

    Registered nurse (rn) - cardiac post procedure - roper hospital

    Thank you for considering a career at Roper St. Francis Healthcare! Scheduled Weekly Hours: 36 Work Shift: Days/Evenings (United States of America) Seeking prior cardiac RN experience Summary of...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    5 days ago

    Certified medical assistant or licensed practical nurse - dermatology - muscp

    Job Description Summary Join our dynamic team at MUSC Clements Ferry Medical Pavilion! Clements Ferry Medical Pavilion is a new state-of-the-art outpatient multi-specialty building where we foster a...

    onsite, Charleston, SC, United States
    Full TimeEntry with Degree
  • AdamsPlace

    AdamsPlace

    6 days ago

    Lpn licensed practical nurse

    Position: Licensed Practical Nurse (LPN) Are you looking to make a difference in the lives of others by sharing your care and compassion? Do you enjoy connecting with your patients while getting to...

    onsite, Charleston, SC, United States
    Full TimeEntry with Degree
  • UnitedHealth Group

    UnitedHealth Group

    6 days ago

    Lpn licensed practical nurse home health

    Explore opportunities with Amedisys, part of the Optum family of businesses. We provide home health, hospice and community-based services that help people receive quality care where they feel most...

    onsite, Charleston, SC, United States
    $49k – $74k/yrFull TimeJunior (<2 years)
  • HCA Healthcare

    HCA Healthcare

    6 days ago

    Medical surgical clinical nurse coordinator rn

    Introduction Do you want to be appreciated daily? Our nurses are celebrated for being on the front line, empathetic for patients. At HCA Healthcare Trident Hospital our nurses set us apart from any...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • HCA Healthcare

    HCA Healthcare

    6 days ago

    Nurse educator women's services and pediatrics

    As a Nurse Educator Women's Services and Pediatrics, your voice to influence patient care is valued and empowered at every turn –whether through open, collaborative relationships with your direct...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • HCA Healthcare

    HCA Healthcare

    6 days ago

    Neuro med surg clinical nurse coordinator rn

    As a Neuro Med Surg Clinical Nurse Coordinator RN, your voice to influence patient care is valued and empowered at every turn –whether through open, collaborative relationships with your direct...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • HCA Healthcare

    HCA Healthcare

    6 days ago

    Rn or clinical nurse coordinator - head and neck

    Sign On Bonus Available Job Summary and Qualifications The Head and Neck Surgical Nurse Coordinator (CNC) ensures exceptional, patient-centered care and seamless coordination of all head and neck...

    onsite, Charleston, SC, United States
    Full TimeDirector
  • HCA Healthcare

    HCA Healthcare

    6 days ago

    Critical care clinical nurse coordinator

    Ready for a role that supports your unique calling in patient care and fits your life? At HCA Healthcare Trident Hospital, you’ll find clear pathways to advance backed by our unmatched nationwide...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • HCA Healthcare

    HCA Healthcare

    6 days ago

    Rn progressive care clinical nurse coordinator

    As a RN Progressive Care Clinical Nurse Coordinator, your voice to influence patient care is valued and empowered at every turn –whether through open, collaborative relationships with your direct...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • HCA Healthcare

    HCA Healthcare

    6 days ago

    Emergency room clinical nurse coordinator rn

    As the nation’s largest private employer of Registered Nurses, we’re honored by the trust of over 100,000 nurses and committed to supporting safe, high-quality care for which they can practice....

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • HCA Healthcare

    HCA Healthcare

    6 days ago

    Transition to practice nurse educator ed

    Ready for a role that supports your unique calling in patient care and fits your life? At HCA Healthcare Trident Hospital, you’ll find clear pathways to advance backed by our unmatched nationwide...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    7 days ago

    Nurse practitioner or physician assistant - hematology oncology

    Job Description Summary The successful applicant will be an Advanced Practice Provider interested in working full-time in the care of patients with cancer- specifically those enrolled in clinical...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    8 days ago

    Clinic lead nurse i - pain/ pm&r - muscp

    Job Description Summary The Ambulatory Clinic RN Lead I reports to the Ambulatory Service Manager. Under general supervision, the Clinic Lead Nurse provides individualized, goal-directed patient care...

    onsite, Charleston, SC, United States
    Full TimeLead / Manager
  • Medical University of South Carolina

    Medical University of South Carolina

    8 days ago

    Clinic lead nurse ii - muscp

    Job Description Summary The Ambulatory Clinic RN Lead II reports to the Manager. Under general supervision, the Clinic Lead Nurse provides individualized, goal-directed patient care to families and...

    onsite, Charleston, SC, United States
    Full TimeLead / Manager
  • Bishop Gadsden Episcopal Retirement

    Bishop Gadsden Episcopal Retirement

    8 days ago

    Assisted living nurse manager (lpn), monday-friday 7am-3pm

    Assisted Living Nurse Manager, LPN Full Time, Monday thru Friday-7am to 3pm If you're ready to build a career where relationships come first, we invite you to join our team. As our Assisted Living...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • AdamsPlace

    AdamsPlace

    10 days ago

    Lpn licensed practical nurse, 2nd shift

    LPN Licensed Practical Nurse - Full Time, 2nd Shift Pay Starting at $25 / hour Depending On Experience Are you looking to make a difference in the lives of others by sharing your care and compassion?...

    onsite, Charleston, SC, United States
    $50k/yrFull TimeJunior (<2 years)
  • C

    Charleston Oncology

    11 days ago

    Nurse practitioner – hematology/oncology with bmt & cellular therapy focus

    Nurse Practitioner – Hematology/Oncology with BMT & Cellular Therapy Focus Charleston Oncology | Charleston, SC (with travel to Mount Pleasant) | Full-time No night call You already know how to...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Veterans Health Administration

    Veterans Health Administration

    11 days ago

    Nurse manager-outpatient specialty clinics

    Summary Functions as a clinical expert and is responsible and accountable for all elements of the nursing process when providing or supervising direct patient care. Assesses, plans, implements, and...

    onsite, Charleston, SC, United States
    $88k/yrFull TimeMiddle (2-4 years)
  • PruittHealth

    PruittHealth

    14 days ago

    Regional manager nurse practitioner

    Nurse Practitioner or Physician Assistant NP PA- PruittHealth Premier Services Long Term Care Health Plan - Must be licensed in SC Monday -Friday with Flexibility No Eve or Weekend onsite Required...

    onsite, Charleston, SC, United States
    Full TimeLead / Manager
  • Sono Bello

    Sono Bello

    15 days ago

    Registered nurse

    Sono Bello is America's top cosmetic surgery specialist, with 185+ board-certified surgeons who have performed over 300,000 laser liposuction and body contouring procedures. A career at Sono Bello...

    onsite, Charleston, SC, United States
    $56k – $71k/yrFull TimeJunior (<2 years)
  • Monroe+Biomedical+Research

    Monroe+Biomedical+Research

    17 days ago

    Clinical research nurse practitioner / physician assistant

    ABOUT THE ROLE Monroe Biomedical Research (MBR) is growing, and we are seeking an experienced, patient-focused Clinical Research Nurse Practitioner/Physician Assistant to join our Charleston team....

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Roper St. Francis Healthcare

    Roper St. Francis Healthcare

    20 days ago

    Registered nurse (rn) - preop and post-anesthesia care unit (pacu) - roper hospital

    Thank you for considering a career at Roper St. Francis Healthcare! Scheduled Weekly Hours: 36 Work Shift: Days/Evenings (United States of America) Shift/Schedule: Monday - Friday, Preop shifts 6:00...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    20 days ago

    Nurse practitioner or physician assistant - pediatrics hematology & oncology

    Job Description Summary The Department of Pediatrics, Division of Pediatric Hematology & Oncology is recruiting for an Advanced Practice Provider (NP/PA) to work full time primarily in the Pediatric...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    21 days ago

    Psychiatric emergency services nurse manager

    Job Description Summary Manages one or more functional areas of a department. Manages two or more professional and support staff including subordinate supervisors. Typically has hire, fire, or...

    onsite, Charleston, SC, United States
    Full TimeLead / Manager
  • Roper St. Francis Healthcare

    Roper St. Francis Healthcare

    21 days ago

    Registered nurse (rn) - physician practice - charleston obgyn

    Thank you for considering a career at Roper St. Francis Healthcare! Scheduled Weekly Hours: 40 Work Shift: Days (United States of America) HOURS: 8:00am - 5:00pm Prefer 1-2 years OBGYN or Women's...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health Urgent Care

    Prisma Health Urgent Care

    21 days ago

    Urgent care nurse practitioner or physician assistant- charleston, sc (float)

    Prisma Health Urgent Care seeks talented, patient-oriented Physician Assistants and Nurse Practitioners who are relentlessly dedicated to ensure the delivery of exceptional customer service by...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    23 days ago

    Certified medical assistant or licensed practical nurse- ent/sinus center

    Job Description Summary The ENT clinic has many subspecialties within the clinic enabling a multidisciplinary approach to caring for our patients. The providers we support specialize in facial...

    onsite, Charleston, SC, United States
    Full TimeEntry with Degree
  • Medical University of South Carolina

    Medical University of South Carolina

    24 days ago

    Registered nurse (rn) musc leatherman adolescent inpatient prn

    Job Description Summary Awesome PRN opportunity for an experienced nurse interested in Behavioral Health! Apply today or contact Recruiter Shannon Shaw at shawsh@musc.edu or 843-674-2694 for more...

    onsite, Charleston, SC, United States
    Part TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    24 days ago

    Registered nurse i (new grad) - 7a family medicine

    Job Description Summary Under general supervision, the Registered Nurse I provides individualized, goal-directed patient care to families and patients at the competent level utilizing the principles...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    a month ago

    Nurse practitioner or physician assistant - inpatient neurosurgery

    Job Description Summary Evaluating and managing inpatients on the Neurological Surgery Service. The successful applicant will be an Advanced Practice Provider interested in working full-time in the...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    a month ago

    Certified registered nurse anesthetist (crna) – shawn jenkins children’s hospital

    Job Description Summary The MUSC Shawn Jenkins Children’s Hospital is a pediatric level-one academic trauma center in Charleston, SC. There are eight operating suites and two cardiac cath labs on...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    a month ago

    Nurse practitioner or physician assistant - hospital medicine

    Job Description Summary The successful applicant will be an Advanced Practice Provider interested in working full-time in the care of patients on various different Hospital Medicine service lines....

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    a month ago

    Certified registered nurse anesthetist (crna) – ashley river tower

    Job Description Summary The MUSC Ashley River Tower hospital is an adult care centered academic facility in Charleston, SC. We have 10 operating rooms as well as a robust NORA practice including 7...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    a month ago

    Certified registered nurse anesthetist (crna) – university hospital (main)

    Job Description Summary Sign-On Bonus Eligible The University Hospital operating area is the central receiving unit within a level-one, academic trauma center. There are 21- OR suites which cover all...

    onsite, Charleston, SC, United States
    $101k/yrFull TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    a month ago

    Certified registered nurse anesthetist (crna) - charleston

    Job Description Summary Sign-On Bonus Available The Certified Registered Nurse Anesthetist provides anesthesia care to a wide variety of patients from pre-term neonates to geriatrics. Administers...

    onsite, Charleston, SC, United States
    Full TimeJunior (<2 years)
  • Medical University of South Carolina

    Medical University of South Carolina

    a month ago

    Univ - registered nurse iii -department of sctr

    Job Description Summary Serve as a Research Nurse providing a wide range of technical, clinical and professional services within the SCTR Nexus Clinical Research Unit and satellite locations. Serve...

    onsite, Charleston, SC, United States
    $67k/yrFull TimeJunior (<2 years)
  • Veterans Health Administration

    Veterans Health Administration

    a month ago

    Nurse manager - community care

    Summary This vacancy is for a Nurse Manager (RN) in the Community Care department at the Charleston VA Medical Center. Duties Designated first-line supervisory authority. Responsible/accountable for...

    onsite, Charleston, SC, United States
    $88k/yrFull TimeMiddle (2-4 years)
  • Veterans Health Administration

    Veterans Health Administration

    a month ago

    Registered nurse assistant nurse manager

    Summary The Non-Supervisory Assistant Nurse Manager (ANM) supports the Nurse Manager (NM) in overseeing operations of a nursing unit/patient care area. Fosters team development, ensures compliance...

    onsite, Charleston, SC, United States
    $88k/yrFull TimeJunior (<2 years)

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