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  2. South Dakota
  3. Sioux Falls
  4. LPN

Onsite Lpn jobs in Sioux Falls, South Dakota, USA

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      Sarah Jenkins

    • 2:30 PM - 3:00 PM

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      Alex Chen

  • Mon
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      David G. (Hiring Manager)

    • 4:15 PM - 5:15 PM

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      Sophie L.

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    • 1:20 PM - 1:45 PM

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      Marta W.

    • 2:30 PM - 3:00 PM

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      Daria (HR)

  • Wed
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      Qualifying Interview

      James Miller

    • 5:30 PM - 6:00 PM

      Discovery Interview

      Chris V.

  • Thu
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      First Interview

      Michael T.

    • 4:00 PM - 5:00 PM

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LPN Jobs in Sioux Falls — On-Site Opportunities Await

Sioux Falls continues to see steady demand for skilled licensed practical nurses as local clinics and care facilities expand their teams. With 102 open positions available, this on-site role offers a great opportunity to join South Dakota's growing healthcare community and fill LPN jobs in Sioux Falls.

Successful candidates bring strong clinical skills, including medication administration, wound care, and patient monitoring, paired with clear communication and organizational ability. Compassion and attention to detail remain essential, since LPNs often serve as the key link between patients and physicians. Familiarity with electronic health records and a collaborative mindset help nurses thrive, making these LPN vacancies appealing to dedicated professionals.

On-site work remains standard for nursing roles in Sioux Falls, where direct patient interaction and immediate team coordination are vital to quality care. The city's expanding healthcare network, including hospitals and outpatient clinics, drives strong demand for nursing professionals. Facilities throughout South Dakota are eager to hire an LPN ready for on-site responsibilities.

If you're ready to advance your nursing career, explore current LPN positions available through Global Work AI and find the right fit for your skills. These opportunities in Sioux Falls offer meaningful work and room for growth—take the next step toward a rewarding career today.

Frequently Asked
Questions

Everything you need to know about
finding your next role
  • What is the average LPN salary in Sioux Falls?

    In Sioux Falls, LPN pay is shaped by local demand in hospitals, clinics, and long-term care communities, plus years of experience and specialty area. Recent market estimates for South Dakota place many licensed practical nurses in the mid-$50,000s annually, with hourly rates often landing around the mid-to-high $20s. Shift differentials, weekend coverage, and employer benefits can move that number up. Because wages vary by facility and credential mix, it helps to review current Sioux Falls listings and compare similar bedside roles before making a decision.
  • What does an LPN do in a hospital, clinic, or long-term care setting?

    This role centers on direct patient care under the supervision of an RN or physician. In a hospital, clinic, or long-term care setting, an LPN may take vital signs, administer medications, assist with wound care, collect specimens, update charts, and observe changes in patient condition. In South Dakota facilities, duties can shift by setting and patient acuity, especially in Sioux Falls where employers serve both acute and elder-care populations. The work is hands-on, so it helps to compare job descriptions to see how responsibilities differ by unit.
  • What licenses and qualifications are required to work as an LPN in South Dakota?

    To practice as an LPN in South Dakota, you must complete an approved practical nursing program and pass the NCLEX-PN exam for state licensure. The South Dakota Board of Nursing also expects applicants to meet background and compliance requirements, and active license status must be maintained through renewal rules. Many Sioux Falls employers look for current CPR certification, strong clinical references, and any recent experience in med-surg, rehab, or long-term care. Reviewing board standards and employer preferences can help you line up the right documents before applying.
  • What skills are most important for an LPN role in Sioux Falls?

    Success in Sioux Falls LPN jobs depends on a mix of clinical skill and steady judgment. Employers usually value safe medication administration, accurate charting, infection-control habits, and the ability to notice subtle changes in a patient’s condition. Communication matters too, since practical nurses coordinate closely with RNs, providers, families, and support staff in busy South Dakota facilities. Reliability, teamwork, and calm response under pressure are especially important in on-site care environments. If you are updating your resume, it helps to match these strengths to the setting you want most.
  • What are the typical work hours and shift schedules for on-site LPN jobs in Sioux Falls?

    Schedules in Sioux Falls often depend on the care setting. Hospitals and skilled nursing facilities may offer 8-hour, 10-hour, or 12-hour shifts, with days, evenings, overnights, weekends, and holidays all in rotation. Clinics usually follow more regular weekday hours, while long-term care can include more flexible coverage patterns. Because on-site LPN work in South Dakota must support direct patient needs, overtime and shift differentials are common in some facilities. Checking postings closely can help you compare what each employer expects from its schedule.
  • How does the hiring process work for LPN positions in Sioux Falls?

    Most employers start with an online application and screening of your license, experience, and availability. In Sioux Falls, the process often includes a phone or recruiter interview, a skills or competency review, reference checks, and pre-employment steps such as drug screening, background review, and proof of immunizations or certifications. Some South Dakota facilities also ask about recent patient populations or charting systems used. Since timelines vary, it is useful to keep your credentials current and compare several openings so you can move quickly when the right match appears.
  • What career growth opportunities are available for an LPN in South Dakota?

    South Dakota offers several paths for an LPN who wants to advance. Many professionals move into specialty areas such as rehab, hospice, dialysis, or long-term care leadership, while others pursue bridge education to become an RN or BSN-prepared nurse. In Sioux Falls, larger health systems and care networks may provide tuition support, mentoring, and cross-training that can strengthen your next step. Experience in multiple settings can make your profile more competitive, so it is worth comparing employers that support continuing education and internal promotion.

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102 jobs found

  • Interim HealthCare - Sioux Falls, SD

    Interim HealthCare - Sioux Falls, SD

    Today

    Licensed practical nurse (lpn)

    Who we are: Interim HealthCare is America's leading provider of home care and healthcare staffing. As a family owned, women owned, and veteran owned business, we have been in Sioux Falls the past 34+...

    onsite, Brookings, SD, United States
    $81k – $85k/yrPart TimeJunior (<2 years)
  • BAART Programs

    BAART Programs

    Today

    Dispensing nurse (lpn)

    Part Time Dispensing Nurse – LPN BAART Programs is looking for a detail oriented and empathetic Licensed Practical Nurse to dispense prescribed medications as part of a treatment team in partnership...

    onsite, Sioux Falls, SD, United States
    Part TimeJunior (<2 years)
  • Avera Health

    Avera Health

    Today

    Registered nurse (rn) or licensed practical nurse (lpn) | 69th and western clinic

    Location: Avera 69th & Western Clinic Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent upon...

    onsite, Sioux Falls, SD, United States
    $45k – $83k/yrFull TimeJunior (<2 years)
  • ADVANCED CORRECTIONAL HEALTHCARE

    ADVANCED CORRECTIONAL HEALTHCARE

    2 days ago

    Registered nurse - prn $45-$47/hr

    Job Details: Job Location: Minnehaha County Juvenile Detention Center - Sioux Falls, SD Position Type: PRN Education Level: 2 Year Degree Salary Range: $45.00 - $47.00 Hourly Travel Percentage:...

    onsite, Sioux Falls, SD, United States
    $91k – $95k/yrFull TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    2 days ago

    Rn - registered nurse - stress lab - part time days

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $65k – $97k/yrPart TimeJunior (<2 years)
  • Avera Health

    Avera Health

    3 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) | hematology & bone marrow transplant clinic

    Location: Hematology, Transplant and Cellular Therapy Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate...

    onsite, Sioux Falls, SD, United States
    $45k – $83k/yrFull TimeJunior (<2 years)
  • The Goodman Group and Affiliates

    The Goodman Group and Affiliates

    5 days ago

    Lpn supervisor eve shift-assisted living

    LPN Supervisor Summary of Position The primary purpose of this position is to supervise the daily nursing activities of the facility during the shift. Such supervision must be in accordance with...

    onsite, Sioux Falls, SD, United States
    Full TimeJunior (<2 years)
  • Touchmark

    Touchmark

    6 days ago

    Registered nurse

    ETHIC – Excellence, Teamwork, Hospitality, Integrity, and Compassion – steadfastly characterizes our mission to continually enrich the daily lives of residents. We practice these principles with...

    onsite, Sioux Falls, SD, United States
    Full TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    6 days ago

    Rn - registered nurse - pre-experience and recovery care - pre op office - prn

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $65k – $97k/yrPart TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    7 days ago

    Rn - registered nurse - pre-experience and recovery care - prn

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $65k – $97k/yrPart TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    7 days ago

    Lpn - full-time nights - sf center

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $52k – $73k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    8 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) | clinic

    Location: Avera Internal Medicine Cliff Ave Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent...

    onsite, Sioux Falls, SD, United States
    $45k – $83k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    9 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) | gastroenterology clinic | prn

    Location: Avera Gastroenterology Sioux Falls Worker Type: PRN Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent...

    onsite, Sioux Falls, SD, United States
    $45k – $83k/yrPart TimeJunior (<2 years)
  • The Goodman Group, LLC

    The Goodman Group, LLC

    10 days ago

    Lpn supervisor evening shift-assisted living

    LPN Supervisor Summary of Position The primary purpose of this position is to supervise the daily nursing activities of the facility during the shift. Such supervision must be in accordance with...

    onsite, Sioux Falls, SD, United States
    Full TimeJunior (<2 years)
  • Avera Health

    Avera Health

    10 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) or medical assistant | dermatology clinic

    Location: Avera Dermatology Minnesota Ave Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent...

    onsite, Sioux Falls, SD, United States
    $40k – $83k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    10 days ago

    Registered nurse (rn) | psychiatry clinic | prn

    Location: Avera Behavioral Health Sioux Falls Worker Type: PRN Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent...

    onsite, Sioux Falls, SD, United States
    $56k – $83k/yrFull TimeJunior (<2 years)
  • Interim HealthCare - Sioux Falls, SD

    Interim HealthCare - Sioux Falls, SD

    10 days ago

    Licensed practical nurse - pediatrics

    Licensed Practical Nurse - Pediatrics $34-36 Per Hour | Paid Weekly | Flexible Shifts Who We Are Interim HealthCare is a leading provider of home care and healthcare staffing services across America....

    onsite, Sioux Falls, SD, United States
    $69k – $73k/yrPart TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    13 days ago

    Lpn - licensed practical nurse - cardiovascular institute

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $44k – $59k/yrFull TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    15 days ago

    Licensed practical nurse - lpn - orthopedics & sports medicine

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $44k – $59k/yrFull TimeJunior (<2 years)
  • DAKOTABILITIES INC

    DAKOTABILITIES INC

    15 days ago

    Lpn

    Job Details Job Location: Longfellow - Sioux Falls, SD Position Type: LPN/RN Nurse Salary Range: Undisclosed Job Shift: Overnights Job Category: Nurse MISSION STATEMENT Working together, we create...

    onsite, Sioux Falls, SD, United States
    Full TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    17 days ago

    Lpn - licensed practical nurse - ma - medical assistant - pct - patient care tech - post acute care - ft days

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $33k – $59k/yrFull TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    17 days ago

    Lpn - licensed practical nurse - acute care - ft

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $44k – $59k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    17 days ago

    Registered nurse (rn) or licensed practical nurse or medical assistant | plastic surgery clinic

    Location: Avera Plastic & Reconstructive Surgery Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate...

    onsite, Sioux Falls, SD, United States
    $45k – $83k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    20 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) | behavioral health child unit

    Location: Avera Behavioral Health Center-Sioux Falls Worker Type: Regular Work Shift: Night Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay...

    onsite, Sioux Falls, SD, United States
    $49k – $98k/yrFull TimeMiddle (2-4 years)
  • Sanford Health

    Sanford Health

    21 days ago

    Rn or lpn - occupational medicine

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $44k – $78k/yrFull TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    21 days ago

    Lpn - licensed practical nurse - diabetes & thyroid clinic - ft days

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $44k – $59k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    21 days ago

    Licensed practical nurse (lpn) | discharge lounge

    Location: Avera McKennan Hospital Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent upon...

    onsite, Sioux Falls, SD, United States
    $49k – $68k/yrFull TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    22 days ago

    Lpn or ma - hospice - prn

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $46k – $73k/yrPart TimeJunior (<2 years)
  • Avera Health

    Avera Health

    22 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) or medical assistant | obgyn

    Location: Avera Obstetrics & Gynecology Plaza 1 Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate...

    onsite, Sioux Falls, SD, United States
    $40k – $83k/yrFull TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    22 days ago

    Lpn - part time pms - sf village

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $52k – $73k/yrPart TimeSenior (5+ years)
  • Sanford Health

    Sanford Health

    22 days ago

    Lpn - part time days - sf village

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $52k – $73k/yrPart TimeSenior (5+ years)
  • Sanford Health

    Sanford Health

    22 days ago

    Lpn - licensed practical nurse or ma - medical assistant - diabetes & thyroid clinic - ft days

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $38k – $58k/yrFull TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    22 days ago

    Licensed practical nurse - lpn - plastic surgery

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $44k – $59k/yrFull TimeJunior (<2 years)
  • Sanford Health

    Sanford Health

    22 days ago

    Lpn - full time days - sf village

    Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland....

    onsite, Sioux Falls, SD, United States
    $52k – $73k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    23 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) or medical assistant | mcgreevy 7th ave clinic

    Location: Avera 7th Avenue Clinic Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent upon...

    onsite, Sioux Falls, SD, United States
    $40k – $83k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    24 days ago

    Registered nurse (rn) or licensed practical nurse (lpn) | dawley farm pediatrics

    Location: Avera Family Medicine Center Dawley Farm Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate...

    onsite, Sioux Falls, SD, United States
    $45k – $83k/yrFull TimeJunior (<2 years)
  • Smithfield Foods

    Smithfield Foods

    a month ago

    Nurse (lpn)

    If you are currently employed at Smithfield, please log into Workday and submit your application through the Jobs Hub. Have a seat at our table. When you join Smithfield, you become part of something...

    onsite, Sioux Falls, SD, United States
    Full TimeJunior (<2 years)
  • Avera Health

    Avera Health

    a month ago

    Registered nurse (rn) or licensed practical nurse (lpn) | transitional care unit

    Location: Avera Prince of Peace-Transitional Care Worker Type: Regular Work Shift: Day/Evening/Weekend/Holiday Shift (United States of America) Pay Range: The pay range for this position is listed...

    onsite, Sioux Falls, SD, United States
    $49k – $98k/yrFull TimeJunior (<2 years)
  • Avera Health

    Avera Health

    a month ago

    Registered nurse (rn) or licensed practical nurse (lpn) | specialty clinic float

    Location: Plaza 4-Sioux Falls Worker Type: Regular Work Shift: Day Shift (United States of America) Pay Range: The pay range for this position is listed below. Actual pay rate dependent upon...

    onsite, Sioux Falls, SD, United States
    $45k – $64k/yrFull TimeJunior (<2 years)
  • Limitless Male

    Limitless Male

    a month ago

    Registered nurse or licensed practical nurse

    About Limitless Male Medical Limitless Male Medical Clinic is a leader in men’s health optimization, focused on helping patients look, feel, and perform at their best. Through personalized care,...

    onsite, Sioux Falls, SD, United States
    Full TimeEntry with Degree

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