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  1. Onsite Jobs
  2. South Carolina
  3. LPN

Onsite Lpn jobs in South Carolina, USA

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LPN Jobs in South Carolina — On-Site Opportunities Await

South Carolina healthcare facilities are actively seeking dedicated LPNs to join on-site care teams across the state. With 500+ open positions available, this is an excellent time to explore LPN vacancies and find a role that matches your clinical expertise and career goals. Growing patient populations continue to drive strong demand for skilled nursing professionals throughout the region.

Successful candidates bring strong clinical skills including medication administration, wound care, and patient monitoring, along with excellent communication and documentation abilities. Employers look for LPNs who can collaborate effectively within multidisciplinary teams, adapt to varying patient needs, and maintain composure in fast-paced environments. Compassion, attention to detail, and a commitment to patient safety remain essential qualities that hiring managers prioritize when they hire an LPN for their facility.

On-site work remains the standard for this profession, as hands-on patient care requires direct presence in clinical settings such as hospitals, long-term care facilities, and physician offices. South Carolina's healthcare sector continues to expand, creating steady demand for LPN positions in both urban centers and smaller communities. This consistent growth offers job seekers reliable opportunities and long-term career stability within the field.

If you're ready to advance your nursing career, now is the perfect moment to explore LPN opportunities throughout South Carolina. Global Work AI connects dedicated professionals with employers seeking reliable, compassionate talent, making it easier than ever to discover a role that fits your skills and ambitions. Start your search today and take the next step toward a rewarding nursing career.

Frequently Asked
Questions

Everything you need to know about
finding your next role
  • What is the average LPN salary in South Carolina for on-site roles?

    In South Carolina, on-site practical nursing pay typically falls in the mid-$50,000 range annually, though exact earnings vary by employer, experience, shift, and setting. Hospitals, long-term care centers, and outpatient clinics often offer different pay structures, and night or weekend schedules may include differentials. In larger metro areas such as Charleston, Columbia, and Greenville, compensation can run higher than in smaller markets. Benefits, overtime, and staffing demand also affect total value. Reviewing current local listings is the best way to compare rates for an LPN role in the state.
  • What qualifications do I need to apply for an LPN job?

    Most employers in South Carolina expect completion of a state-approved practical nursing program and eligibility for licensure through the South Carolina Board of Nursing. A diploma or certificate from an accredited LPN program is usually required, along with clinical training in patient care. Many hiring managers also prefer recent experience in a hospital, clinic, or nursing facility, though entry-level opportunities do exist. A clean background check, immunization records, and proof of CPR certification are commonly requested. Checking individual postings will help you match your background to each opening.
  • What are the main duties of an LPN in a hospital, clinic, or nursing facility?

    Day-to-day responsibilities usually center on direct patient support and routine clinical tasks. An on-site LPN may take vital signs, assist with bathing and mobility, collect specimens, document symptoms, monitor changes in condition, and help administer medications under supervision. In South Carolina healthcare settings, LPNs also support care plans, communicate updates to registered nurses and providers, and help families understand basic instructions. The exact scope depends on the employer and care environment, so comparing hospital, clinic, and nursing facility postings can clarify expectations.
  • What skills do employers look for in an LPN for on-site healthcare jobs?

    Strong bedside manner matters, but employers also look for technical accuracy, clear communication, and steady judgment under pressure. For on-site healthcare jobs in South Carolina, an LPN should be comfortable with medication administration, charting, infection control, and basic patient assessment. Organization and time management are important in busy units, while empathy and teamwork help with resident and patient interactions. Adaptability is valuable too, since schedules and caseloads can shift quickly. Reviewing job descriptions can reveal which abilities are most important for each employer.
  • Is an active South Carolina practical nurse license required, and what other certifications may be needed?

    Yes, an active South Carolina practical nurse license is required for legal practice in the state. Employers may also ask for current CPR or BLS certification, and some facilities prefer additional training such as IV therapy, dementia care, or specialty-specific credentials depending on the unit. Health screens, TB testing, and proof of immunizations are often part of onboarding in hospitals and nursing facilities. If you hold an out-of-state license, confirm endorsement requirements early so you can line up paperwork before reviewing open roles.
  • How does the hiring process usually work for LPN jobs, from application to offer?

    The process usually starts with an online application and resume review, followed by one or more interviews with nursing leadership or HR. For many South Carolina on-site LPN openings, employers then verify credentials, license status, work history, references, and background information before making a final decision. Some facilities include a skills assessment or unit tour, especially in hospitals and long-term care settings. After an offer, onboarding often includes health clearance, orientation, and policy training. Tracking each step can help you compare timelines across different listings.
  • What career growth opportunities are available for LPNs, including advancement into rn roles?

    An LPN can build toward broader responsibility through specialty experience, additional certifications, and continuing education. In South Carolina, many practical nurses move into charge support, treatment roles, or focused areas such as wound care, rehab, or long-term care coordination. Advancement into rn roles is also common, often through LPN-to-RN bridge programs that may lead to an associate or bachelor's degree pathway. Employers sometimes support tuition assistance or flexible scheduling for school. Comparing local education options alongside current openings can help map the next stage of your career.

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500+ jobs found

  • 4

    470c3739-c393-41f5-a53b-47708e3adf0e

    Today

    Lpn-licensed practical nurse - $3500 sign on bonus - aiken co.

    We are currently seeking Full Time Licensed Practical Nurses to join our team at Aiken County Detention Center located in Aiken, South Carolina . GENESYS Health Alliance proudly manages our...

    onsite, Aiken, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    Today

    Licensed practical nurse (lpn)-acute care, emergency department, ft, night

    Inspire health. Serve with compassion. Be the difference. Job Summary Under the direction of a Registered Nurse/Physician, provides nursing care for patients. Assumes responsibility for data...

    onsite, Greenville, SC, United States
    Full TimeJunior (<2 years)
  • Sprenger Wellspring Silver Maple

    Sprenger Wellspring Silver Maple

    Today

    Assisted living nurse manager - lpn

    Job Details: Job Location: SHC of Port Royal - Port Royal, SC, Salary Range: Undisclosed, Sprenger Health Care is a third generation, leading developer, owner and operator of senior living...

    onsite, Port Royal, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    Today

    Licensed practical nurse (lpn), med/surg, rn, full-time, nights

    Inspire health. Serve with compassion. Be the difference. Job Summary Under the direction of a Registered Nurse/Physician, provides nursing care for patients. Assumes responsibility for data...

    onsite, Seneca, SC, United States
    Full TimeJunior (<2 years)
  • Spartanburg Regional Healthcare System

    Spartanburg Regional Healthcare System

    Today

    Patient experience navigator - licensed practical nurse (lpn)

    Job Requirements Position Summary The Patient Experience Navigator supports and guides patients throughout the healthcare continuum by coordinating care, removing barriers, and promoting clear,...

    onsite, Spartanburg, SC, United States
    Full TimeJunior (<2 years)
  • UnitedHealth Group

    UnitedHealth Group

    a day ago

    Licensed practical nurse (lpn) or licensed vocational nurse (lvn) - home health

    Explore opportunities with Amedisys, part of the Optum family of businesses. We provide home health, hospice and community-based services that help people receive quality care where they feel most...

    onsite, Conway, SC, United States
    $47k – $70k/yrFull TimeJunior (<2 years)
  • Wellpath

    Wellpath

    a day ago

    Licensed practical nurse (lpn) - days

    You Matter Make a difference every day in the lives of the underserved. Join a mission driven organization with a people first culture. Excellent career growth opportunities. Join us and find a...

    onsite, Newport, SC, United States
    Full TimeJunior (<2 years)
  • PruittHealth

    PruittHealth

    a day ago

    Licensed practical nurse lpn home health per diem

    Licensed Practical Nurse LPN – Home Health Services Per Diem Special consideration for applicants who currently live in or commutable to Lexington, Richland or Kershaw. Home is where the heart is!...

    onsite, Kershaw, SC, United States
    Part TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    2 days ago

    Licensed practical nurse (lpn) - long-term acute care, progressive care, pt, night

    Inspire health. Serve with compassion. Be the difference. Job Summary Under the direction of a Registered Nurse/Physician, provides nursing care for patients. Assumes responsibility for data...

    onsite, Travelers Rest, SC, United States
    Part TimeJunior (<2 years)
  • GRIFOLS, S.A.

    GRIFOLS, S.A.

    3 days ago

    Lpn

    Would you like to join an international team working to improve the future of healthcare? Do you want to enhance the lives of millions of people? Grifols is a global healthcare company that since...

    onsite, Greenwood, SC, United States
    Full TimeJunior (<2 years)
  • Lake Emory Post Acute Care

    Lake Emory Post Acute Care

    5 days ago

    Licensed practical nurse lpn

    Position Summary Working in harmony with the entire nursing staff, the Licensed Practical Nurse strives to provide the very best care possible. If you are a Licensed Practical Nurse with a true...

    onsite, Inman, SC, United States
    $60k – $69k/yrFull TimeJunior (<2 years)
  • Lake City Scranton Health Care Cener

    Lake City Scranton Health Care Cener

    5 days ago

    Licensed practical nurse lpn

    Job Highlights Come join our amazing clinical team! We are hiring full time and prn LPNs! 7am-7pm, 7pm-7am, and prn. Position Summary Working in harmony with the entire nursing staff, the Licensed...

    onsite, Scranton, SC, United States
    $60k – $69k/yrFull TimeJunior (<2 years)
  • Physical Rehabilitation and Wellness Center

    Physical Rehabilitation and Wellness Center

    5 days ago

    Licensed practical nurse lpn

    Job Highlights Why join the PRWC team as an LPN-Licensed Practical Nurse? Now offering a $4,000.00 sign on bonus for newly hired, full time LPNs. Newly hired full time LPNs must start on or before...

    onsite, Spartanburg, SC, United States
    $60k – $71k/yrFull TimeJunior (<2 years)
  • Oakbrook Health and Rehabilitation Center

    Oakbrook Health and Rehabilitation Center

    5 days ago

    Licensed practical nurse lpn

    Job Highlights Why Join Oakbrook as an LPN - Licensed Practical Nurse? We offer a nursing loan repayment program for full-time hires! We have an awesome team! We are hiring full time and part time...

    onsite, Summerville, SC, United States
    $54k – $71k/yrFull TimeJunior (<2 years)
  • Riverside Health and Rehabilitation

    Riverside Health and Rehabilitation

    5 days ago

    Licensed practical nurse lpn

    Job Highlights Why join the Riverside team as an LPN-Licensed Practical Nurse? We have full-time shifts. (Includes every other weekend) 7am-7pm, and 7pm-7am! We have a great clinical team! Diamond...

    onsite, North Charleston, SC, United States
    $56k – $65k/yrFull TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    5 days ago

    Licensed practical nurse (lpn)-ambulatory, family and internal medicine-seneca, ft, day

    Inspire health. Serve with compassion. Be the difference. Job Summary Under the supervision of a provider and in collaboration with other team members, provides basic nursing care in a non-acute...

    onsite, Seneca, SC, United States
    Full TimeEntry with Degree
  • Prisma Health

    Prisma Health

    5 days ago

    Licensed practical nurse (lpn) - ambulatory, geriatric care, ft, days

    Licensed Practical Nurse (LPN) - Ambulatory, Geriatric Care, FT, Days Inspire health. Serve with compassion. Be the difference. Job Summary Under the supervision of a provider and in collaboration...

    onsite, Greenville, SC, United States
    Full TimeEntry with Degree
  • UnitedHealth Group

    UnitedHealth Group

    5 days ago

    Lpn licensed practical nurse home health

    Explore opportunities with Amedisys, part of the Optum family of businesses. We provide home health, hospice and community-based services that help people receive quality care where they feel most...

    onsite, Charleston, SC, United States
    $49k – $74k/yrFull TimeJunior (<2 years)
  • BAYADA Home Health Care

    BAYADA Home Health Care

    5 days ago

    Lpn - 1:1 pediatric nurse

    Fall Into Purpose-Driven Nursing with BAYADA Our Rock Hill Office is interested in a Licensed Practical Nurse (LPN) who has a passion for homecare to join our Skilled Private Duty Nursing team. We...

    onsite, Rock Hill, SC, United States
    $52k – $56k/yrPart TimeJunior (<2 years)
  • UHS

    UHS

    6 days ago

    Lpn licensed practical nurse adolescent

    Responsibilities Night Shift LPN 7pm - 7:30am Inpatient Acute Unit for adolescent program. This position will float as needed to other units based on needs to include dual diagnosis, acute inpatient...

    onsite, Lexington, SC, United States
    Full TimeEntry with Degree
  • Prisma Health Urgent Care

    Prisma Health Urgent Care

    6 days ago

    Licensed practical nurse (lpn) beaufort/hilton head

    Prisma Health Urgent Care - Delivering Quality Care with Purpose Are you a passionate LPN looking for a dynamic and rewarding career? Join Prisma Health Urgent Care, where you'll make a meaningful...

    onsite, Beaufort, SC, United States
    Full TimeJunior (<2 years)
  • Merakey

    Merakey

    6 days ago

    Licensed practical nurse - lpn - school based

    Are you looking for an opportunity to advance your career while working with an extraordinary team? At Merakey, we put heart and soul into everything we do. We are seeking a School Licensed Practical...

    onsite, Mt. Pleasant, SC, United States
    $54k/yrFull TimeJunior (<2 years)
  • BAYADA Home Health Care

    BAYADA Home Health Care

    9 days ago

    Private duty nurse (lpn)

    Fall Into Purpose-Driven Nursing with BAYADA Our Columbia Skilled Office is interested in a Licensed Practical Nurse (LPN) who has a passion for home care to join our Skilled Private Duty Nursing...

    onsite, Columbia, SC, United States
    $52k – $56k/yrPart TimeJunior (<2 years)
  • Lexington Medical Center

    Lexington Medical Center

    9 days ago

    Lpn-pn

    Lexington Health is a comprehensive network of care that includes six community medical and urgent care centers, nearly 80 physician practices, more than 9,000 health care professionals and Lexington...

    onsite, West Columbia, SC, United States
    Full TimeJunior (<2 years)
  • BAYADA Home Health Care

    BAYADA Home Health Care

    9 days ago

    Home care nurse (lpn)

    Fall Into Purpose-Driven Nursing with BAYADA Our Upstate Skilled Office is interested in a Licensed Practical Nurse (LPN) who has a passion for homecare to join our Skilled Private Duty Nursing team....

    onsite, Abbeville, SC, United States
    $52k – $56k/yrPart TimeJunior (<2 years)
  • BAYADA Home Health Care

    BAYADA Home Health Care

    9 days ago

    Lpn-licensed practical nurse

    Fall Into Purpose-Driven Nursing with BAYADA Our Upstate Skilled Office is interested in a Licensed Practical Nurse (LPN) who has a passion for homecare to join our Skilled Private Duty Nursing team....

    onsite, Clemson, SC, United States
    $52k – $56k/yrPart TimeJunior (<2 years)
  • AdamsPlace

    AdamsPlace

    9 days ago

    Lpn licensed practical nurse, 2nd shift

    LPN Licensed Practical Nurse - Full Time, 2nd Shift Pay Starting at $25 / hour Depending On Experience Are you looking to make a difference in the lives of others by sharing your care and compassion?...

    onsite, Charleston, SC, United States
    $50k/yrFull TimeJunior (<2 years)
  • Wellpath

    Wellpath

    12 days ago

    Licensed practical nurse (lpn) - nights

    You Matter Make a difference every day in the lives of the underserved Join a mission driven organization with a people first culture Excellent career growth opportunities Join us and find a career...

    onsite, Newport, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    12 days ago

    Licensed practical nurse (lpn) - acute, care, rehabilitation, ft, nights

    Inspire health. Serve with compassion. Be the difference. Job Summary Under the direction of a Registered Nurse/Physician, provides nursing care for patients. Assumes responsibility for data...

    onsite, Greenville, SC, United States
    Full TimeJunior (<2 years)
  • Agape Care Group

    Agape Care Group

    14 days ago

    Licensed practical nurse (lpn)

    Overview Join Our Team as a Licensed Practical Nurse (LPN) Do you value the time you spend with your patients? Is it important to you that your patients and their families know and feel that you are...

    onsite, Rock Hill, SC, United States
    Full TimeJunior (<2 years)
  • AdamsPlace

    AdamsPlace

    16 days ago

    Lpn licensed practical nurse (prn)

    Position: Licensed Practical Nurse (LPN) Are you looking to make a difference in the lives of others by sharing your care and compassion? Do you enjoy connecting with your patients while getting to...

    onsite, Greenville, SC, United States
    Part TimeJunior (<2 years)
  • BAYADA Home Health Care

    BAYADA Home Health Care

    16 days ago

    Lpn - home care nurse

    This Fall, Find a Better Way to Nurse with BAYADA Our Columbia Skilled Office is interested in a Licensed Practical Nurse (LPN) who has a passion for home care to join our Skilled Private Duty...

    onsite, Columbia, SC, United States
    $52k – $56k/yrPart TimeEntry with Degree
  • Prisma Health

    Prisma Health

    22 days ago

    Licensed practical nurse (lpn) ambulatory, hillcrest family medicine, pt, day

    Inspire health. Serve with compassion. Be the difference. Job Summary Under the supervision of a provider and in collaboration with other team members, provides basic nursing care in a non-acute...

    onsite, Simpsonville, SC, United States
    Part TimeEntry with Degree
  • Prisma Health

    Prisma Health

    25 days ago

    Licensed practical nurse (lpn) - nurse resident, winter 2027, general medicine

    Inspire health. Serve with compassion. Be the difference. Job Summary Responsibility of attending all quality and core curriculum classes, actively participating in professional development workshops...

    onsite, Greenville, SC, United States
    Full TimeEntry with Degree
  • Prisma Health

    Prisma Health

    a month ago

    Licensed practical nurse (lpn)-ambulatory, sumter ob, ft, day

    Inspire health. Serve with compassion. Be the difference. Job Summary Under the supervision of a provider and in collaboration with other team members, provides basic nursing care in a non-acute...

    onsite, Sumter, SC, United States
    Full TimeEntry with Degree
  • Angels of Care Pediatric Home Health

    Angels of Care Pediatric Home Health

    a month ago

    Licensed practical nurse (lpn) / registered nurse (rn) – private duty pediatric nurse

    Licensed Practical Nurse (LPN) / Registered Nurse (RN) – Private Duty Pediatric Nurse Irmo, SC | Surrounding Areas Pay Range: $29+/hour Make a Difference One Patient at a Time Angels of Care...

    onsite, Irmo, SC, United States
    $58k/yrPart TimeJunior (<2 years)
  • Saratoga Medical Center

    Saratoga Medical Center

    a month ago

    Licensed practical nurse (lpn)

    Saratoga Medical is hiring Licensed Practical/Vocational Nurses (LPN/LVNs) for onsite opportunities in South Carolina. This is a great contract opportunity to provide nursing care at correctional...

    onsite, Ridgeville, SC, United States
    Full TimeJunior (<2 years)
  • Prisma Health

    Prisma Health

    a month ago

    Licensed practical nurse (lpn) nurse resident, december 2026, general medicine

    Inspire health. Serve with compassion. Be the difference. Job Summary Responsibility of attending all quality and core curriculum classes, actively participating in professional development workshops...

    onsite, Greenville, SC, United States
    Full TimeEntry with Degree
  • Millcroft

    Millcroft

    a month ago

    Licensed practical nurse (lpn)

    When you become a part of The Cypress of Hilton Head, you gain a front-row seat to the incredible life stories of some of the wisest individuals on earth. Beyond that, you join an extraordinary...

    onsite, Hilton Head Island, SC, United States
    Part TimeJunior (<2 years)
  • Liberty Community Living Center

    Liberty Community Living Center

    a month ago

    Licensed practical nurse (lpn) -

    Licensed Practical Nurse (LPN) Community Eldercare Services (CES) is looking for a Licensed Practical Nurse (LPN) to join our growing team! If you are a highly skilled, caring, compassionate Licensed...

    onsite, Liberty, SC, United States
    Full TimeJunior (<2 years)

10,000,000+ more jobs available!